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LMNA(1-646) [nuclear envelope]
Stable Identifier
R-HSA-535479
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nuclear envelope
Synonyms
LMNA, Lamin-A/C, LMNA_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q6ZNE9 RUFY4
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Unfolded Protein Response (UPR) (Homo sapiens)
IRE1alpha activates chaperones (Homo sapiens)
XBP1(S) activates chaperone genes (Homo sapiens)
Expression of LMNA (Homo sapiens)
LMNA(1-646) [nuclear envelope] (Homo sapiens)
External Reference Information
External Reference
UniProt:P02545 LMNA
Gene Names
LMNA, LMN1
Chain
chain:1-661, chain:1-646, propeptide:647-661, propeptide:662-664
Reference Genes
ENSEMBL:ENSG00000160789 LMNA
Participates
as an output of
Expression of LMNA (Homo sapiens)
Other forms of this molecule
LMNA(1-567)-p-RAF1(279-648) fusion [cytosol]
LMNA(1-567)-RAF1(279-648) fusion [cytosol]
Interactors (90)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P20700 LMNB1
8
LMNB1 [nucleoplasm]
(R-HSA-264867)
LMNB1(1-231) [nuclear envelope]
(R-HSA-352244)
LMNB1(232-586) [nuclear envelope]
(R-HSA-352248)
LMNB1 [cytosol]
(R-HSA-2995384)
p-S395, S405-LMNB1 [nucleoplasm]
(R-HSA-5228738)
p-S23, S395, S405-LMNB1 [nucleoplasm]
(R-HSA-5229018)
LMNB1(2-586) [nuclear envelope]
(R-HSA-912402)
p-S23,S393-LMNB1 [nucleoplasm]
(R-HSA-8868341)
0.933
23
UniProt:Q03252 LMNB2
0.849
10
UniProt:P50402 EMD
4
EMD [nuclear envelope]
(R-HSA-201573)
EMD [cytosol]
(R-HSA-9613988)
EMD [endoplasmic reticulum membrane]
(R-HSA-9613998)
EMD [endosome membrane]
(R-HSA-9715092)
0.799
7
UniProt:Q9UII6 DS13B
0.781
7
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.774
23
UniProt:Q9UH99 SUN2
1
SUN2 [nuclear envelope]
(R-HSA-912382)
0.723
5
UniProt:O75694 NUP155
2
NUP155 [cytosol]
(R-HSA-9634170)
NUP155 [nuclear envelope]
(R-HSA-157690)
0.672
6
UniProt:Q13573 SNW1
1
SNW1 [nucleoplasm]
(R-HSA-351663)
0.666
4
UniProt:P42166 TMPO
0.629
4
UniProt:P16104 H2AFX
7
H2AFX [nucleoplasm]
(R-HSA-56151)
p-Y143-H2AFX [nucleoplasm]
(R-HSA-5683942)
p-S140,Y143-H2AFX [nucleoplasm]
(R-HSA-5683953)
p-S140-H2AFX [nucleoplasm]
(R-HSA-75170)
K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm]
(R-HSA-5682847)
H2AFX [extracellular region]
(R-HSA-977583)
Me2sR4-H2AFX [nucleoplasm]
(R-HSA-5218317)
0.604
3
UniProt:Q0D2I5-5 IFFO1
0.576
4
UniProt:O60684 KPNA6
2
KPNA6 [nucleoplasm]
(R-HSA-9734665)
KPNA6 [cytosol]
(R-HSA-9734672)
0.569
5
UniProt:P42167 TMPO
1
TMPO [cytosol]
(R-HSA-9714330)
0.569
4
UniProt:O94901 SUN1
1
SUN1 [nuclear envelope]
(R-HSA-912371)
0.564
2
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.564
2
UniProt:P62701 RPS4X
2
RPS4X [cytosol]
(R-HSA-72375)
RPS4X [nucleoplasm]
(R-HSA-6798713)
0.556
3
UniProt:Q3B820 F161A
0.556
3
UniProt:Q7Z699 SPRED1
2
SPRED1 [plasma membrane]
(R-HSA-5658225)
SPRED1 [cytosol]
(R-HSA-5654207)
0.556
3
UniProt:Q96MN9-2 Q96MN92
0.556
3
UniProt:Q7Z698 SPRED2
2
SPRED2 [cytosol]
(R-HSA-5654211)
SPRED2 [plasma membrane]
(R-HSA-5658229)
0.556
3
UniProt:Q96LX8 ZNF597
1
ZNF597 [nucleoplasm]
(R-HSA-2127591)
0.556
3
UniProt:Q8WXF7 ATLA1
0.556
3
UniProt:Q86WT6-2 TRIM69
0.556
3
UniProt:Q70EL1-9 USP54
0.556
3
UniProt:Q9C0F3 ZNF436
1
ZNF436 [nucleoplasm]
(R-HSA-1247538)
0.556
3
UniProt:P17024 ZNF20
1
ZNF20 [nucleoplasm]
(R-HSA-975024)
0.556
3
UniProt:Q9NWB1-5 RBFOX1
0.556
3
UniProt:Q14585 ZN345
0.556
3
UniProt:Q6ZNH5 ZN497
0.556
3
IntAct:EBI-25842396 CCSB
0.556
3
UniProt:P60409 KRTAP10-7
1
KRTAP10-7 [cytosol]
(R-HSA-6810279)
0.556
3
UniProt:Q04323-2 UBXN1
0.556
3
IntAct:EBI-10171679 386682
0.556
3
UniProt:Q9BS31 ZNF649
1
ZNF649 [nucleoplasm]
(R-HSA-2127585)
0.556
3
UniProt:O43309 ZSC12
0.556
3
UniProt:Q7Z3I7 ZN572
0.556
3
UniProt:Q8IZU1 FAM9A
0.556
3
UniProt:Q9Y4E8-2 USP15
0.556
3
UniProt:Q96EL1 INKA1
0.556
3
UniProt:P46379-2 BAG6
0.556
3
UniProt:Q9HBE1-4 PATZ1
0.556
3
UniProt:Q6H8Q1-8 ABLIM2
0.556
3
UniProt:Q9BZ95-3 Q9BZ953
0.556
3
UniProt:Q8N0Y2-2 ZNF444
0.556
3
UniProt:A6H8Z2-3 A6H8Z23
0.556
3
UniProt:O76041 NEBL
0.556
3
UniProt:Q99612 KLF6
0.556
3
UniProt:Q96GN5-2 CDCA7L
0.556
3
UniProt:Q96KP6 TNIP3
1
TNIP3 [cytosol]
(R-HSA-561192)
0.556
3
UniProt:Q8TBE0 BAHD1
0.556
3
UniProt:Q8NEA9 GMCL2
0.556
3
UniProt:Q12986 NFX1
0.556
3
UniProt:Q5VYS8-5 TUT7
0.556
3
UniProt:Q03181-2 PPARD
0.556
3
UniProt:Q8NA54 IQUB
0.556
3
UniProt:Q8WVD3 RNF138
1
RNF138 [cytosol]
(R-HSA-976008)
0.556
3
UniProt:Q8TCX5 RHPN1
1
RHPN1 [cytosol]
(R-HSA-5667017)
0.556
3
UniProt:Q8TBZ8 ZNF564
1
ZNF564 [nucleoplasm]
(R-HSA-1973885)
0.556
3
UniProt:Q14005-2 Q140052
0.556
3
UniProt:Q15776 ZKSCAN8
1
ZKSCAN8 [nucleoplasm]
(R-HSA-974985)
0.556
3
UniProt:Q96FA3 PELI1
2
PELI1 [cytosol]
(R-HSA-450696)
p-PELI1 [cytosol]
(R-HSA-450815)
0.556
3
UniProt:Q9UNE7 STUB1
1
STUB1 [cytosol]
(R-HSA-975970)
0.556
3
UniProt:Q8WW38 ZFPM2
1
ZFPM2 [nucleoplasm]
(R-HSA-996726)
0.556
3
UniProt:O75925 PIAS1
1
PIAS1 [nucleoplasm]
(R-HSA-877307)
0.556
3
UniProt:Q9ULD4-2 Q9ULD42
0.556
3
UniProt:Q96DX5 ASB9
1
ASB9 [cytosol]
(R-HSA-975424)
0.556
3
UniProt:Q8N488 RYBP
1
RYBP [nucleoplasm]
(R-HSA-8937975)
0.556
3
UniProt:Q8IYM2 SLN12
0.556
3
UniProt:Q13123 IK
1
IK [nucleoplasm]
(R-HSA-9770239)
0.556
3
UniProt:Q9Y239 NOD1
1
NOD1 [cytosol]
(R-HSA-168407)
0.556
3
IntAct:EBI-25851697 CCSB
0.556
3
UniProt:Q3SX64 CMA1D
0.556
3
UniProt:Q6ZN57 ZFP2
1
ZFP2 [nucleoplasm]
(R-HSA-975018)
0.556
3
UniProt:Q6X4W1-6 NSMF
0.556
3
UniProt:O75886 STAM2
2
Ub-STAM2 [cytosol]
(R-HSA-6782781)
STAM2 [cytosol]
(R-HSA-182965)
0.556
3
UniProt:Q13133-3 NR1H3
0.556
3
UniProt:P10074 TZAP
0.556
3
UniProt:P58499 FAM3B
0.556
3
UniProt:P54274-2 TERF1
0.556
3
UniProt:P10073 ZSC22
0.556
3
UniProt:Q6ZNE9 RUFY4
0.556
3
UniProt:Q9D666 Sun1
1
Sun1 [nuclear envelope]
(R-MMU-912375)
0.528
2
UniProt:O75531 BANF1
4
p-T2,T3,S4-BANF1 [cytosol]
(R-HSA-2995375)
BANF1 [cytosol]
(R-HSA-175371)
BANF1 [nucleoplasm]
(R-HSA-175030)
p-T2,T3,S4-BANF1 [nucleoplasm]
(R-HSA-2993896)
0.527
2
UniProt:P17029 ZKSCAN1
1
ZKSCAN1 [nucleoplasm]
(R-HSA-975013)
0.527
2
UniProt:P01106 MYC
2
MYC [nucleoplasm]
(R-HSA-188379)
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
0.527
3
UniProt:P18054 ALOX12
1
ALOX12 [cytosol]
(R-HSA-2142768)
0.508
4
UniProt:Q8NC56 LEMD2
1
LEMD2 [nuclear envelope]
(R-HSA-3067329)
0.491
2
UniProt:O75937 DNAJC8
1
DNAJC8 [nucleoplasm]
(R-HSA-53703)
0.483
3
UniProt:Q9H2H8 PPIL3
1
PPIL3 [nucleoplasm]
(R-HSA-8952110)
0.483
2
UniProt:Q8WXH0-1 SYNE2
0.463
3
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