Reactome | TPP1 [lysosomal lumen]

TPP1 [lysosomal lumen]

Stable Identifier

R-HSA-535504

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

lysosomal lumen

Synonyms

Tripeptidyl-peptidase 1, TPP1_HUMAN

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Unfolded Protein Response (UPR) (Homo sapiens)
    - IRE1alpha activates chaperones (Homo sapiens)
      - XBP1(S) activates chaperone genes (Homo sapiens)
        
        Expression of TPP1 (Homo sapiens)
        
        TPP1 [lysosomal lumen] (Homo sapiens)

External Reference Information

External Reference

UniProt:O14773 TPP1

Gene Names

TPP1, CLN2, GIG1, UNQ267/PRO304

Chain

signal peptide:1-19, propeptide:20-195, chain:196-563

Reference Genes

BioGPS Gene:1200 TPP1

COSMIC (genes):TPP1 TPP1

CTD Gene:1200 TPP1

dbSNP Gene:1200 TPP1

ENSEMBL:ENSG00000166340 TPP1

ENSEMBL_homo_sapiens_GENE:ENSG00000166340.18 TPP1

HGNC:2073 TPP1

KEGG Gene (Homo sapiens):1200 TPP1

Monarch:1200 TPP1

NCBI Gene:1200 TPP1

OMIM:607998 TPP1

UCSC:O14773 TPP1

Reference Transcript

RefSeq:NM_000391.3 TPP1

Other Identifiers

11725032_a_at

11748341_a_at

11748342_x_at

11752596_s_at

11752817_s_at

11752885_x_at

11753248_a_at

11753249_x_at

11757469_s_at

1200

16655907

16735137

16735152

18671321

18671322

18671323

18671324

18671325

18671326

18671327

200742_PM_s_at

200742_s_at

200743_PM_s_at

200743_s_at

214196_PM_s_at

214196_s_at

32824_at

3361030

3361031

3361032

3361033

3361034

3361035

3361036

3361037

3361038

3361040

3361042

3361043

3361044

3361045

3361046

3361047

3361048

3361049

3361051

3361054

3361055

3361056

3361058

3361060

3361061

3361063

3361064

3361065

3361067

3361069

3361070

3361071

7892758

7892766

7893029

7894195

7894492

7895866

7946221

7946228

868_at

A_24_P38815

A_33_P3324454

GE54344

GO:0003824

GO:0004175

GO:0004252

GO:0005515

GO:0005576

GO:0005615

GO:0005764

GO:0005768

GO:0005773

GO:0005794

GO:0006508

GO:0006629

GO:0007040

GO:0007399

GO:0007417

GO:0008233

GO:0008236

GO:0008240

GO:0008289

GO:0016787

GO:0030154

GO:0030163

GO:0030855

GO:0031410

GO:0035727

GO:0042277

GO:0042470

GO:0043171

GO:0043202

GO:0043226

GO:0045121

GO:0045453

GO:0046872

GO:0048856

GO:0050877

GO:0050885

GO:0055037

GO:0070062

GO:0070198

GO:0120146

GO:0140096

GO:1905146

HMNXSV003005971

Hs.20478.0.A1_3p_a_at

Hs.20478.1.A1_3p_a_at

ILMN_1729234

PH_hs_0025203

TC11001361.hg

TC11001362.hg

TC11003034.hg

U13991_at

g5597012_3p_a_at

Participates

as an output of

Expression of TPP1 (Homo sapiens)

Cross References

RefSeq

NP_000382.3

OpenTargets

ENSG00000166340

HPA

ENSG00000166340-TPP1

GeneCards

O14773

Ensembl

ENST00000642892, ENSP00000494165, ENSP00000493657, ENSP00000299427, ENSP00000495893, ENST00000299427, ENST00000645620, ENST00000647152, ENST00000533371, ENSG00000166340, ENSP00000437066

PRO

O14773

Pharos - Targets

O14773

Orphanet

15652

HMDB Protein

HMDBP14587

PDB

3EE6, 3EDY

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P45974-2 USP5			0.556	3
UniProt:Q6P3S6 FBX42			0.556	3
UniProt:Q96D59 RN183			0.556	3
UniProt:Q53EZ4 CEP55			0.556	3
UniProt:Q9NSE2 CISH	1	CISH [cytosol] (R-HSA-1169213)	0.556	3
UniProt:Q96FW1 OTUB1	2	OTUB1 [cytosol] (R-HSA-933411) OTUB1 [nucleoplasm] (R-HSA-6783242)	0.556	3
UniProt:Q9UKA2 FBXL4	1	FBXL4 [cytosol] (R-HSA-8850899)	0.556	3
UniProt:Q8NAP3 ZBT38			0.556	3
UniProt:Q9BUZ4 TRAF4			0.556	3
UniProt:Q9NWX5-2 Q9NWX52			0.556	3
UniProt:O00308 WWP2	1	WWP2 [cytosol] (R-HSA-6807279)	0.556	3
UniProt:E5LBV4 E5LBV4			0.524	2