Reactome | TPP1 [lysosomal lumen]

Stable Identifier

R-HSA-535504

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

lysosomal lumen

Synonyms

Tripeptidyl-peptidase 1, TPP1_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q9NSE2 CISH

Expand all

Cellular responses to stimuli (Homo sapiens)

External Reference Information

External Reference

UniProt:O14773 TPP1

Gene Names

TPP1, CLN2, GIG1, UNQ267/PRO304

Chain

signal peptide:1-19, propeptide:20-195, chain:196-563

Reference Genes

COSMIC (genes):TPP1 TPP1

dbSNP Gene:1200 TPP1

ENSEMBL:ENSG00000166340 TPP1

Participates

as an output of

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q6P3S6 FBX42			0.556	3
UniProt:Q53EZ4 CEP55			0.556	3
UniProt:Q9NSE2 CISH	1	CISH [cytosol] (R-HSA-1169213)	0.556	3
UniProt:Q9UKA2 FBXL4	1	FBXL4 [cytosol] (R-HSA-8850899)	0.556	3
UniProt:Q8NAP3 ZBT38			0.556	3
UniProt:Q9NWX5-2 Q9NWX52			0.556	3
UniProt:Q9BUZ4 TRAF4			0.556	3
UniProt:O00308 WWP2	1	WWP2 [cytosol] (R-HSA-6807279)	0.556	3
UniProt:P45974-2 USP5			0.556	3
UniProt:Q96D59 RN183			0.556	3
UniProt:Q96FW1 OTUB1	2	OTUB1 [nucleoplasm] (R-HSA-6783242) OTUB1 [cytosol] (R-HSA-933411)	0.556	3
UniProt:E5LBV4 E5LBV4			0.524	2
UniProt:Q15388 TOMM20	6	PolyUb-TOMM20 [mitochondrial outer membrane] (R-HSA-6783144) TOMM20 [mitochondrial outer membrane] (R-HSA-1252091) Ub-TOMM20 [mitochondrial outer membrane] (R-HSA-9834976) K48polyUb-TOMM20 [mitochondrial outer membrane] (R-HSA-9843324) K63polyUb-TOMM20 [mitochondrial outer membrane] (R-HSA-9843313) p-S65-Ub:TOMM20 [mitochondrial outer membrane] (R-HSA-9834948)	0.483	3

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