Reactome | KLHDC3 [cytosol]

KLHDC3 [cytosol]

Stable Identifier

R-HSA-535552

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Kelch domain-containing protein 3, KLDC3_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q15369 ELOC

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Unfolded Protein Response (UPR) (Homo sapiens)
    - IRE1alpha activates chaperones (Homo sapiens)
      - XBP1(S) activates chaperone genes (Homo sapiens)
        
        Expression of KLHDC3 (Homo sapiens)
        
        KLHDC3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9BQ90 KLHDC3

Gene Names

KLHDC3, PEAS

Chain

chain:1-382

Reference Genes

BioGPS Gene:116138 KLHDC3

COSMIC (genes):KLHDC3 KLHDC3

CTD Gene:116138 KLHDC3

dbSNP Gene:116138 KLHDC3

ENSEMBL:ENSG00000124702 KLHDC3

ENSEMBL_homo_sapiens_GENE:ENSG00000124702.19 KLHDC3

HGNC:20704 KLHDC3

KEGG Gene (Homo sapiens):116138 KLHDC3

Monarch:116138 KLHDC3

NCBI Gene:116138 KLHDC3

OMIM:611248 KLHDC3

UCSC:Q9BQ90 KLHDC3

Reference Transcript

RefSeq:NM_057161.3 KLHDC3

Other Identifiers

116138

11745551_a_at

11747959_x_at

11752823_x_at

11756252_x_at

17008750

208784_PM_s_at

208784_s_at

214383_PM_x_at

214383_x_at

2907569

2907573

2907574

2907576

2907577

2907578

2907579

2907580

2907581

2907582

2907583

2907585

2907587

2907591

2907592

2907593

2907594

2907595

2907597

2907598

39537_at

8119648

A_24_P343255

GE490389

GO:0000785

GO:0003682

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0006310

GO:0007131

GO:0016567

GO:0022414

GO:0030163

GO:0031462

GO:0036211

GO:0043161

GO:0043226

GO:0051321

GO:0060090

GO:0140013

GO:0140627

GO:1990756

HMNXSV003009724

Hs.281706.2.S1_3p_a_at

ILMN_1730940

TC06000592.hg

TC06002795.hg

X98248_rna1_at

g12804724_3p_x_at

Participates

as an output of

Expression of KLHDC3 (Homo sapiens)

Cross References

RefSeq

NP_476502.1

OpenTargets

ENSG00000124702

HPA

ENSG00000124702-KLHDC3

GeneCards

Q9BQ90

Ensembl

ENSP00000313995, ENST00000326974, ENSG00000124702

PRO

Q9BQ90

Pharos - Targets

Q9BQ90

Interactors (23)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13617 CUL2	3	G76-NEDD8-K689-CUL2 [cytosol] (R-HSA-8952511) CUL2 [nucleoplasm] (R-HSA-1234126) CUL2 [cytosol] (R-HSA-416982)	0.708	11
UniProt:Q92990 GLMN	1	GLMN [cytosol] (R-HSA-8951779)	0.527	2
UniProt:P85037 FOXK1	1	FOXK1 [nucleoplasm] (R-HSA-5689673)	0.527	3
UniProt:P61313 RPL15	1	RPL15 [cytosol] (R-HSA-72416)	0.527	2
UniProt:Q9H6Y2 WDR55			0.527	2
UniProt:Q9BPU6 DPYSL5	3	p-Y-DPYSL5 [cytosol] (R-HSA-399786) DPYSL5 [cytosol] (R-HSA-398138) p-S534-DPYSL5 [cytosol] (R-HSA-399793)	0.527	3
UniProt:Q8IVD9 NUDC3			0.527	3
UniProt:Q7L5N1 COPS6	2	COPS6 [nucleoplasm] (R-HSA-5697026) COPS6 [cytosol] (R-HSA-416961)	0.527	4
UniProt:Q9NS91 RAD18	1	RAD18 [nucleoplasm] (R-HSA-5643731)	0.527	2
UniProt:O75817 POP7	1	POP7 [nucleoplasm] (R-HSA-5696769)	0.527	2
UniProt:Q8IVT2 MISP			0.527	2
UniProt:Q8N5L8 RP25L			0.527	4
UniProt:O14531 DPYSL4	3	p-Y-DPYSL4 [cytosol] (R-HSA-399794) DPYSL4 [cytosol] (R-HSA-398126) p-S544-DPYSL4 [cytosol] (R-HSA-399808)	0.527	2
UniProt:Q9NRA8 4ET			0.527	2
UniProt:Q96FZ2 HMCES			0.527	2
UniProt:Q9Y4X5 ARIH1	1	ARIH1 [cytosol] (R-HSA-1678825)	0.527	2
UniProt:Q9UJ04 TSYL4			0.527	2
UniProt:Q15843 NEDD8	8	C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) NEDD8 [nucleoplasm] (R-HSA-8955926) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739) NEDD8(77-81) [cytosol] (R-HSA-6782654) NEDD8(1-81) [cytosol] (R-HSA-5690794) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) NEDD8 [cytosol] (R-HSA-416969) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895)	0.527	2
UniProt:O94888 WIPF1	2	UBXN7 [cytosol] (R-HSA-8956071) ub-UBXN7 [cytosol] (R-HSA-9755305)	0.527	2
UniProt:Q9UKA1 FBXL5	1	FBXL5 [cytosol] (R-HSA-391295)	0.527	2
UniProt:Q15369 ELOC	2	TCEB1 [nucleoplasm] (R-HSA-112422) ELOC [cytosol] (R-HSA-180535)	0.527	3
UniProt:Q96JC9 EAF1	1	EAF1 [nucleoplasm] (R-HSA-8932787)	0.527	3
UniProt:Q7Z569 BRAP	2	ub-BRAP [cytosol] (R-HSA-5674001) BRAP [cytosol] (R-HSA-5672938)	0.527	4

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