Reactome | CXXC1 [nucleoplasm]

CXXC1 [nucleoplasm]

Stable Identifier

R-HSA-535610

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

CpG-binding protein, CXXC1_HUMAN, CFP1

Locations in the PathwayBrowser for interactor UniProt:Q86VP1 TAX1BP1

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Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Unfolded Protein Response (UPR) (Homo sapiens)
    - IRE1alpha activates chaperones (Homo sapiens)
      - XBP1(S) activates chaperone genes (Homo sapiens)
        
        Expression of CXXC1 (Homo sapiens)
        
        CXXC1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9P0U4 CXXC1

Gene Names

CXXC1, CFP1, CGBP, PCCX1, PHF18

Chain

chain:1-656

Reference Genes

BioGPS Gene:30827 CXXC1

COSMIC (genes):CXXC1 CXXC1

CTD Gene:30827 CXXC1

dbSNP Gene:30827 CXXC1

ENSEMBL:ENSG00000154832 CXXC1

ENSEMBL_homo_sapiens_GENE:ENSG00000154832.16 CXXC1

HGNC:24343 CXXC1

KEGG Gene (Homo sapiens):30827 CXXC1

Monarch:30827 CXXC1

NCBI Gene:30827 CXXC1

OMIM:609150 CXXC1

UCSC:Q9P0U4 CXXC1

Reference Transcript

Other Identifiers

11756831_a_at

11756929_a_at

16855283

218058_3p_at

218058_PM_at

218058_at

30827

3807810

3807811

3807812

3807813

3807815

3807817

3807818

3807820

3807822

3807824

3807825

3807827

3807828

3807829

3807830

3807831

3807833

3807835

3807836

3807837

3807839

3807843

3807844

3807851

3807852

48580_PM_at

48580_at

8023344

A_23_P141779

GE62202

GO:0000987

GO:0003677

GO:0005515

GO:0005634

GO:0005654

GO:0005829

GO:0006351

GO:0006355

GO:0008270

GO:0016363

GO:0016607

GO:0035064

GO:0035097

GO:0042393

GO:0043226

GO:0045322

GO:0045893

GO:0046872

GO:0048188

HMNXSV003013130

ILMN_1691276

PH_hs_0010708

PH_hs_0032027

TC18000513.hg

g7656974_3p_at

g7656974_3p_s_at

Participates

as a component of

as an input of

as an output of

Expression of CXXC1 (Homo sapiens)

Inferred To

cxxc1b [nucleoplasm] (Danio rerio)

Cxxc1 [nucleoplasm] (Rattus norvegicus)

gflC [nucleoplasm] (Dictyostelium discoideum)

CXXC1 [nucleoplasm] (Bos taurus)

CXXC1 [nucleoplasm] (Canis familiaris)

CXXC1 [nucleoplasm] (Drosophila melanogaster)

CXXC1 [nucleoplasm] (Mus musculus)

CXXC1 [nucleoplasm] (Saccharomyces cerevisiae)

CXXC1 [nucleoplasm] (Sus scrofa)

cfp-1 [nucleoplasm] (Caenorhabditis elegans)

spp1 [nucleoplasm] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_055408.2, NP_001095124.1, XP_016881207.1, XP_011524242.1

OpenTargets

ENSG00000154832

GeneCards

Q9P0U4

HPA

ENSG00000154832-CXXC1

Ensembl

ENSP00000285106, ENSP00000390475, ENSG00000154832, ENST00000285106, ENST00000412036

PRO

Q9P0U4

Pharos - Targets

Q9P0U4

PDB

3QMI, 3QMD, 3QMH, 3QMC, 3QMG, 3QMB

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.812	7
UniProt:Q9UBL3 ASH2L	1	ASH2L [nucleoplasm] (R-HSA-1629834)	0.758	8
UniProt:Q15291 RBBP5	1	RBBP5 [nucleoplasm] (R-HSA-1629836)	0.737	8
UniProt:O15047 SETD1A	1	SETD1A [nucleoplasm] (R-HSA-3239027)	0.69	6
UniProt:Q9C005 DPY30	1	DPY30 [nucleoplasm] (R-HSA-5669104)	0.643	4
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.597	7
UniProt:P50222 MEOX2			0.556	3
UniProt:Q86VP1 TAX1BP1	1	TAX1BP1 [cytosol] (R-HSA-937346)	0.556	3
UniProt:O15294 OGT	2	OGT [nucleoplasm] (R-HSA-3321845) OGT [cytosol] (R-HSA-9687814)	0.527	2
UniProt:Q8NFC6 BOD1L1	1	BOD1L1 [nucleoplasm] (R-HSA-8954547)	0.527	3
UniProt:Q9UPS6 SETD1B	1	SETD1B [nucleoplasm] (R-HSA-5244714)	0.527	3
UniProt:Q96IK1 BOD1	1	BOD1 [nucleoplasm] (R-HSA-9821926)	0.527	2
UniProt:P60484 PTEN	20	K48polyUb-PTEN [cytosol] (R-HSA-8874327) PolyUb-PTEN [nucleoplasm] (R-HSA-6782515) PTEN H93R [cytosol] (R-HSA-2318524) PTEN C124R [cytosol] (R-HSA-2317439) PTEN H93Y [cytosol] (R-HSA-2318520) PTEN R130G [cytosol] (R-HSA-2317339) PTEN H93D [cytosol] (R-HSA-2318550) PTEN R130L [cytosol] (R-HSA-2317430) PTEN H93A [cytosol] (R-HSA-2318544) PTEN G129E [cytosol] (R-HSA-2318509) PTEN S170N [cytosol] (R-HSA-2318408) PTEN R173P [cytosol] (R-HSA-2317480) PTEN R130Q [cytosol] (R-HSA-2317416) PTEN H93Q [cytosol] (R-HSA-2318565) PTEN G129R [cytosol] (R-HSA-2318501) PTEN H123Y [cytosol] (R-HSA-2318469) PTEN S170R [cytosol] (R-HSA-2318437) PTEN R173C [cytosol] (R-HSA-2317478) PTEN R173H [cytosol] (R-HSA-2317473) PTEN C124S [cytosol] (R-HSA-2317379)	0.508	2
UniProt:Q6UXN9 WDR82	1	WDR82 [nucleoplasm] (R-HSA-9821474)	0.462	3
UniProt:P51610 HCFC1	2	HCFC1 [nucleoplasm] (R-HSA-1592209) K48polyUb,K63polyUb-HCFC1 [nucleoplasm] (R-HSA-5690821)	0.462	2
UniProt:Q09472 EP300	5	monoSUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306) Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) EP300 [nucleoplasm] (R-HSA-381325)	0.462	2

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