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p-Y779,Y821-AXL [plasma membrane]
Stable Identifier
R-HSA-5357460
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
AXL autophosphorylates on Y779 and Y821 (Homo sapiens)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL [plasma membrane] (Homo sapiens)
p-Y779,Y821-AXL [plasma membrane] (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K/VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y772,Y814-AXL:PI3K [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL:PI3K [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL [plasma membrane] (Homo sapiens)
p-Y779,Y821-AXL [plasma membrane] (Homo sapiens)
p-AXL binds PI3K (Homo sapiens)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL [plasma membrane] (Homo sapiens)
p-Y779,Y821-AXL [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL:PI3K [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL [plasma membrane] (Homo sapiens)
p-Y779,Y821-AXL [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P30530 AXL
Gene Names
AXL, UFO
Chain
signal peptide:1-25, chain:26-894
Reference Genes
BioGPS Gene:558 AXL
COSMIC (genes):AXL AXL
CTD Gene:558 AXL
dbSNP Gene:558 AXL
ENSEMBL:ENSG00000167601 AXL
ENSEMBL_homo_sapiens_GENE:ENSG00000167601.12 AXL
HGNC:905 AXL
KEGG Gene (Homo sapiens):558 AXL
Monarch:558 AXL
NCBI Gene:558 AXL
OMIM:109135 AXL
UCSC:P30530 AXL
Reference Transcript
RefSeq:NM_021913.4 AXL
RefSeq:NM_001699.5 AXL
Other Identifiers
11716586_a_at
11716587_at
1233_s_at
1278_at
16862439
202685_PM_s_at
202685_s_at
202686_PM_s_at
202686_s_at
3834048
3834049
3834050
3834051
3834052
3834054
3834055
3834056
3834058
3834059
3834060
3834062
3834064
3834065
3834069
3834071
3834074
3834075
3834076
3834078
3834080
3834082
3834083
3834084
3834085
3834086
3834087
3834088
3834090
3834091
3834092
3834145
38433_at
558
8029006
A_23_P208389
GE81057
GO:0000166
GO:0001618
GO:0001764
GO:0001779
GO:0001786
GO:0001818
GO:0001961
GO:0001974
GO:0002376
GO:0003824
GO:0004672
GO:0004713
GO:0004714
GO:0005515
GO:0005524
GO:0005576
GO:0005615
GO:0005856
GO:0005886
GO:0006468
GO:0006909
GO:0006915
GO:0006954
GO:0007155
GO:0007165
GO:0007167
GO:0007169
GO:0007283
GO:0007399
GO:0008092
GO:0008289
GO:0009986
GO:0010936
GO:0012501
GO:0015629
GO:0016020
GO:0016192
GO:0016301
GO:0016310
GO:0016477
GO:0016740
GO:0021885
GO:0022414
GO:0023052
GO:0030154
GO:0030168
GO:0031100
GO:0031668
GO:0032036
GO:0032689
GO:0032720
GO:0032825
GO:0032940
GO:0034101
GO:0034446
GO:0035457
GO:0036211
GO:0042060
GO:0042698
GO:0043066
GO:0043226
GO:0043231
GO:0043235
GO:0043277
GO:0043491
GO:0043524
GO:0043548
GO:0045087
GO:0046649
GO:0046718
GO:0048010
GO:0048469
GO:0048549
GO:0048678
GO:0048856
GO:0048870
GO:0051250
GO:0051402
GO:0051649
GO:0051897
GO:0060068
GO:0060089
GO:0070062
GO:0070301
GO:0071222
GO:0097028
GO:0097350
GO:0098542
GO:0140096
GO:1903902
GO:2000669
Hs.83341.1.A1_3p_a_at
ILMN_1701877
ILMN_2364521
M76125_s_at
PH_hs_0004757
TC19000576.hg
g11863122_3p_a_at
Participates
as a component of
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL [plasma membrane] (Homo sapiens)
Other forms of this molecule
AXL [plasma membrane]
Inferred To
Homologues of p-Y779,Y821-AXL [plasma membrane]
(Caenorhabditis elegans)
Ghost homologue of p-Y779,Y821-AXL [plasma membrane]
(Gallus gallus)
phospho-p-Y779,Y821-AXL [plasma membrane]
(Bos taurus)
phospho-p-Y779,Y821-AXL [plasma membrane]
(Caenorhabditis elegans)
phospho-p-Y779,Y821-AXL [plasma membrane]
(Canis familiaris)
phospho-p-Y779,Y821-AXL [plasma membrane]
(Mus musculus)
phospho-p-Y779,Y821-AXL [plasma membrane]
(Rattus norvegicus)
phospho-p-Y779,Y821-AXL [plasma membrane]
(Sus scrofa)
Modified Residues
Name
O4'-phospho-L-tyrosine at 779
Coordinate
779
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 821
Coordinate
821
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_068713.2
,
NP_001690.2
ZINC - World Drugs
UFO_HUMAN
Guide to Pharmacology - Targets
1835
OpenTargets
ENSG00000167601
ZINC - FDA approved
UFO_HUMAN
ZINC - Substances
UFO_HUMAN
ZINC - Biogenic
UFO_HUMAN
ZINC target
P30530
PRO
P30530
PDB
4RA0
,
2C5D
,
5U6B
,
5VXZ
ZINC - Investigational
UFO_HUMAN
ZINC - Metabolites
UFO_HUMAN
HPA
ENSG00000167601-AXL
GeneCards
P30530
Ensembl
ENST00000359092
,
ENSP00000301178
,
ENST00000301178
,
ENSG00000167601
,
ENSP00000351995
Pharos - Targets
P30530
ZINC - Predictions - Purchasable
UFO_HUMAN
HMDB Protein
HMDBP09451
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P0DTC2 S
20
S(686-815) [plasma membrane]
(R-COV-9770188)
Spike S2' Fragment [plasma membrane]
(R-COV-9770189)
S1 [plasma membrane]
(R-COV-9769950)
fully glycosylated Spike [plasma membrane]
(R-COV-9733472)
nascent Spike [endoplasmic reticulum lumen]
(R-COV-9694796)
14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen]
(R-COV-9694459)
Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen]
(R-COV-9696892)
high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen]
(R-COV-9696875)
high-mannose N-glycan folded Spike [endoplasmic reticulum lumen]
(R-COV-9696880)
high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9766369)
high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9696943)
di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9696920)
tri-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9697006)
fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9696997)
complex N-glycan-PALM-Spike S2 Fragment [plasma membrane]
(R-COV-9769952)
fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9698330)
fully glycosylated Spike [virion membrane]
(R-COV-9698327)
complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane]
(R-COV-9694745)
complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane]
(R-COV-9694343)
complex N-glycan-PALM-Spike S2 Fragment [virion membrane]
(R-COV-9694791)
0.655
9
UniProt:P27986 PIK3R1
16
p-Y-PIK3R1 [cytosol]
(R-HSA-9680647)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 [cytosol]
(R-HSA-74789)
PIK3R1 [plasma membrane]
(R-HSA-198365)
0.597
3
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.597
4
UniProt:hspa1a_hspa1b_human-1 EBI-11820565
0.569
4
UniProt:P08238 HSP90AB1
6
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.564
3
UniProt:Q16543 CDC37
1
CDC37 [cytosol]
(R-HSA-1221609)
0.527
3
UniProt:P29317 EPHA2
2
EPHA2 [plasma membrane]
(R-HSA-211422)
p-Y588,Y594-EPHA2 [plasma membrane]
(R-HSA-3928380)
0.499
2
UniProt:Q92665 MRPS31
1
MRPS31 [mitochondrial inner membrane]
(R-HSA-5368198)
0.483
2
UniProt:P14616 INSRR
0.483
2
UniProt:P27824 CANX
2
CANX [lumenal side of endoplasmic reticulum membrane]
(R-HSA-983091)
CANX [endoplasmic reticulum lumen]
(R-HSA-195906)
0.483
2
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.471
4
UniProt:P19174 PLCG1
6
p-Y-PLCG1 [cytosol]
(R-HSA-9029082)
p-4Y-PLCG1 [plasma membrane]
(R-HSA-167679)
PLCG1 [cytosol]
(R-HSA-202320)
PLCG1 [plasma membrane]
(R-HSA-167682)
p-Y771,Y783,Y1254-PLCG1 [cytosol]
(R-HSA-202357)
p-Y771,Y783-PLCG1 [plasma membrane]
(R-HSA-1169084)
0.462
2
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