PAK1-3 autophosphorylates

Stable Identifier
R-HSA-5357472
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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PAK1-3 autophosphorylates
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Increased PAK1-3 catalytic activity is associated with autophosphorylation of key residues, including one site in the regulatory portion (S144 in PAK1) and another in the so-called activation loop (T423 in PAK1).

Literature References
PubMed ID Title Journal Year
11278486 The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity

Manser, E, Lim, L, Chong, C, Tan, L

J Biol Chem 2001
10075701 Multisite autophosphorylation of p21-activated protein kinase gamma-PAK as a function of activation

Huang, Z, Traugh, JA, Tuazon, PT, Gatti, A

J Biol Chem 1999
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of PAK1,2,3 dimer [cytosol]

Physical Entity
PAK1,2,3 dimer [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
PAK1-3 autophosphorylates (Bos taurus)
PAK1-3 autophosphorylates (Caenorhabditis elegans)
PAK1-3 autophosphorylates (Canis familiaris)
PAK1-3 autophosphorylates (Danio rerio)
PAK1-3 autophosphorylates (Drosophila melanogaster)
PAK1-3 autophosphorylates (Gallus gallus)
PAK1-3 autophosphorylates (Mus musculus)
PAK1-3 autophosphorylates (Rattus norvegicus)
PAK1-3 autophosphorylates (Sus scrofa)
PAK1-3 autophosphorylates (Xenopus tropicalis)
Authored
Garapati, P V  (2013-08-30)
Reviewed
Ballmer-Hofer, K  (2014-05-12)
Welsh, M  (2014-05-12)
Berger, P  (2014-05-12)
Created
Garapati, P V  (2014-03-21)
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