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MLH1:PMS2 [nucleoplasm]
Stable Identifier
R-HSA-5357522
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
MutLalpha
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
Mismatch Repair (Homo sapiens)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (Homo sapiens)
EXO1 interacting with MSH2:MSH3 excises DNA strand containing an insertion/deletion loop (IDL) (Homo sapiens)
EXO1:MLH1:PMS2:MSH2:MSH3:ATP:PCNA:DNA containing IDL of 2 or more bases and single strand incision [nucleoplasm] (Homo sapiens)
MLH1:PMS2 [nucleoplasm] (Homo sapiens)
EXO1 interacts with MSH2:MSH3 (MutSbeta) and MLH1:PMS2 (MutLalpha) (Homo sapiens)
EXO1:MLH1:PMS2:MSH2:MSH3:ATP:PCNA:DNA containing IDL of 2 or more bases and single strand incision [nucleoplasm] (Homo sapiens)
MLH1:PMS2 [nucleoplasm] (Homo sapiens)
MLH1:PMS2:MSH2:MSH3:ATP:PCNA:DNA containing IDL of 2 or more bases and single strand incision [nucleoplasm] (Homo sapiens)
MLH1:PMS2 [nucleoplasm] (Homo sapiens)
MLH1:PMS2 makes single strand incision near insertion/deletion loop of 2 bases or more (Homo sapiens)
MLH1:PMS2:MSH2:MSH3:ATP:PCNA:DNA containing IDL of 2 bases or more [nucleoplasm] (Homo sapiens)
MLH1:PMS2 [nucleoplasm] (Homo sapiens)
MLH1:PMS2:MSH2:MSH3:ATP:PCNA:DNA containing IDL of 2 or more bases and single strand incision [nucleoplasm] (Homo sapiens)
MLH1:PMS2 [nucleoplasm] (Homo sapiens)
MSH2:MSH3 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Homo sapiens)
MLH1:PMS2 [nucleoplasm] (Homo sapiens)
MLH1:PMS2:MSH2:MSH3:ATP:PCNA:DNA containing IDL of 2 bases or more [nucleoplasm] (Homo sapiens)
MLH1:PMS2 [nucleoplasm] (Homo sapiens)
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (Homo sapiens)
EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Homo sapiens)
EXO1:MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision [nucleoplasm] (Homo sapiens)
MLH1:PMS2 [nucleoplasm] (Homo sapiens)
EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Homo sapiens)
EXO1:MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision [nucleoplasm] (Homo sapiens)
MLH1:PMS2 [nucleoplasm] (Homo sapiens)
MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision [nucleoplasm] (Homo sapiens)
MLH1:PMS2 [nucleoplasm] (Homo sapiens)
Formation of MSH1:PMS2 Complex (Homo sapiens)
MLH1:PMS2 [nucleoplasm] (Homo sapiens)
MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Homo sapiens)
MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm] (Homo sapiens)
MLH1:PMS2 [nucleoplasm] (Homo sapiens)
MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision [nucleoplasm] (Homo sapiens)
MLH1:PMS2 [nucleoplasm] (Homo sapiens)
MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Homo sapiens)
MLH1:PMS2 [nucleoplasm] (Homo sapiens)
MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm] (Homo sapiens)
MLH1:PMS2 [nucleoplasm] (Homo sapiens)
Participants
components
MLH1 [nucleoplasm]
(Homo sapiens)
PMS2 [nucleoplasm]
(Homo sapiens)
Participates
as an input of
MSH2:MSH3 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Homo sapiens)
MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Homo sapiens)
as a component of
MLH1:PMS2:MSH2:MSH3:ATP:PCNA:DNA containing IDL of 2 bases or more [nucleoplasm] (Homo sapiens)
MLH1:PMS2:MSH2:MSH3:ATP:PCNA:DNA containing IDL of 2 or more bases and single strand incision [nucleoplasm] (Homo sapiens)
EXO1:MLH1:PMS2:MSH2:MSH3:ATP:PCNA:DNA containing IDL of 2 or more bases and single strand incision [nucleoplasm] (Homo sapiens)
EXO1:MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision [nucleoplasm] (Homo sapiens)
MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision [nucleoplasm] (Homo sapiens)
MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm] (Homo sapiens)
as an output of
Formation of MSH1:PMS2 Complex (Homo sapiens)
Inferred To
MLH1:PMS2 [nucleoplasm]
(Bos taurus)
MLH1:PMS2 [nucleoplasm]
(Caenorhabditis elegans)
MLH1:PMS2 [nucleoplasm]
(Canis familiaris)
MLH1:PMS2 [nucleoplasm]
(Danio rerio)
MLH1:PMS2 [nucleoplasm]
(Dictyostelium discoideum)
MLH1:PMS2 [nucleoplasm]
(Drosophila melanogaster)
MLH1:PMS2 [nucleoplasm]
(Gallus gallus)
MLH1:PMS2 [nucleoplasm]
(Mus musculus)
MLH1:PMS2 [nucleoplasm]
(Plasmodium falciparum)
MLH1:PMS2 [nucleoplasm]
(Rattus norvegicus)
MLH1:PMS2 [nucleoplasm]
(Saccharomyces cerevisiae)
MLH1:PMS2 [nucleoplasm]
(Schizosaccharomyces pombe)
MLH1:PMS2 [nucleoplasm]
(Sus scrofa)
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