Reactome | MSH6 [nucleoplasm]

MSH6 [nucleoplasm]

Stable Identifier

R-HSA-5357528

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

DNA mismatch repair protein Msh6, MSH6_HUMAN

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External Reference Information

External Reference

UniProt:P52701 MSH6

Gene Names

MSH6, GTBP

Chain

chain:1-1360

Reference Genes

BioGPS Gene:2956 MSH6

COSMIC (genes):MSH6 MSH6

CTD Gene:2956 MSH6

dbSNP Gene:2956 MSH6

ENSEMBL:ENSG00000116062 MSH6

ENSEMBL_homo_sapiens_GENE:ENSG00000116062.19 MSH6

HGNC:7329 MSH6

KEGG Gene (Homo sapiens):2956 MSH6

Monarch:2956 MSH6

NCBI Gene:2956 MSH6

OMIM:600678 MSH6

UCSC:P52701 MSH6

Reference Transcript

Other Identifiers

11749000_a_at

11755368_a_at

16879923

2003_s_at

202911_PM_at

202911_at

211450_PM_s_at

211450_s_at

2481155

2481156

2481159

2481160

2481162

2481163

2481164

2481169

2481170

2481171

2481173

2481174

2481175

2481176

2481177

2481178

2956

8041888

A_14_P103048

A_14_P124635

A_23_P102202

GE60542

GO:0000166

GO:0000287

GO:0000400

GO:0000710

GO:0000785

GO:0002376

GO:0003677

GO:0003682

GO:0003684

GO:0003690

GO:0003824

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005694

GO:0005794

GO:0005829

GO:0006281

GO:0006298

GO:0006310

GO:0006974

GO:0007283

GO:0008094

GO:0008340

GO:0008630

GO:0009411

GO:0012501

GO:0016446

GO:0016447

GO:0019899

GO:0022414

GO:0023052

GO:0030983

GO:0032137

GO:0032142

GO:0032143

GO:0032301

GO:0032357

GO:0032405

GO:0035064

GO:0042393

GO:0043226

GO:0043231

GO:0043531

GO:0045190

GO:0045910

GO:0048856

GO:0051096

GO:0097193

GO:0140097

GO:0140299

GO:0140657

GO:0140664

HMNXSV003013728

PH_hs_0026021

TC02000299.hg

g2687868_3p_a_at

g4504190_3p_at

Participates

as an input of

as a component of

Other forms of this molecule

MSH6 L222* [nucleoplasm]

Inferred To

msh-6 [nucleoplasm] (Caenorhabditis elegans)

Msh6 [nucleoplasm] (Rattus norvegicus)

msh6 [nucleoplasm] (Danio rerio)

msh6 [nucleoplasm] (Dictyostelium discoideum)

MSH6 [nucleoplasm] (Bos taurus)

MSH6 [nucleoplasm] (Canis familiaris)

MSH6 [nucleoplasm] (Drosophila melanogaster)

MSH6 [nucleoplasm] (Gallus gallus)

MSH6 [nucleoplasm] (Mus musculus)

MSH6 [nucleoplasm] (Plasmodium falciparum)

MSH6 [nucleoplasm] (Saccharomyces cerevisiae)

MSH6 [nucleoplasm] (Schizosaccharomyces pombe)

MSH6 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_001268422.1, NP_001268421.1, NP_001268423.1, NP_000170.1

OpenTargets

ENSG00000116062

HPA

ENSG00000116062-MSH6

GeneCards

P52701

Ensembl

ENSG00000116062, ENSP00000446475, ENSP00000234420, ENST00000540021, ENST00000234420

PRO

P52701

Pharos - Targets

P52701

Orphanet

16467

PDB

2GFU, 2O8F, 2O8B, 8AG6, 2O8D, 6OQM, 2O8C, 2O8E

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P43246 MSH2	3	MSH2 R406* [nucleoplasm] (R-HSA-5575594) MSH2 [nucleoplasm] (R-HSA-5357525) MSH2 GLN601TER [nucleoplasm] (R-HSA-5577243)	0.91	11
UniProt:Q9NXL9 MCM9			0.623	3
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.564	2
UniProt:P12004 PCNA	5	monoSUMO1-K164,K254,K-PCNA [nucleoplasm] (R-HSA-4615861) K63polyUb-K164-PCNA [nucleoplasm] (R-HSA-8943000) ISG-K164,ISG-K168-PCNA [nucleoplasm] (R-HSA-5653768) MonoUb-K164-PCNA [nucleoplasm] (R-HSA-5651986) PCNA [nucleoplasm] (R-HSA-68439)	0.527	2
IntAct:EBI-1187714 41			0.499	2

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