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p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol]
Stable Identifier
R-HSA-5357794
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Synonyms
RIP1:RIP3:MLKL oligomer
Locations in the PathwayBrowser
Expand all
Programmed Cell Death (Homo sapiens)
Regulated Necrosis (Homo sapiens)
RIPK1-mediated regulated necrosis (Homo sapiens)
MLKL binds PIPs (Homo sapiens)
RIP1:RIP3:MLKL oligomer:PIPs [plasma membrane] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:FLOT1:FLOT2 [plasma membrane] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:PDCD6IP:SDCBP [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
MLKL oligomerizes (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
Regulation of necroptotic cell death (Homo sapiens)
MLKL binds FLOT1, FLOT2 (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:FLOT1:FLOT2 [plasma membrane] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
MLKL binds PDCD6IP and SDCBP (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:PDCD6IP:SDCBP [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
Transport of small molecules (Homo sapiens)
Ion channel transport (Homo sapiens)
Stimuli-sensing channels (Homo sapiens)
TRP channels (Homo sapiens)
TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
TRPV1 transports Ca2+ from extracellular region to cytosol (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
TRPs transport extracellular Ca2+ to cytosol (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
24316671
Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis
Wu, LG
,
Ward, Y
,
Zhao, J
,
Cai, Z
,
Liu, J
,
Chiang, HC
,
Jitkaew, S
,
Liu, ZG
,
Choksi, S
Nat. Cell Biol.
2014
Participants
components
p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol]
(Homo sapiens)
p-T357,S358-MLKL oligomer [cytosol]
(Homo sapiens)
Participates
as an input of
MLKL binds FLOT1, FLOT2 (Homo sapiens)
MLKL binds PDCD6IP and SDCBP (Homo sapiens)
MLKL binds PIPs (Homo sapiens)
as a component of
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:PDCD6IP:SDCBP [cytosol] (Homo sapiens)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:FLOT1:FLOT2 [plasma membrane] (Homo sapiens)
RIP1:RIP3:MLKL oligomer:PIPs [plasma membrane] (Homo sapiens)
as an output of
MLKL oligomerizes (Homo sapiens)
This entity regulates
Positively
TRPA1 tetramer transports Ca2+ from extracellular region to cytosol
(Homo sapiens)
TRPs transport extracellular Ca2+ to cytosol
(Homo sapiens)
TRPV1 transports Ca2+ from extracellular region to cytosol
(Homo sapiens)
Inferred To
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol]
(Bos taurus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol]
(Mus musculus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol]
(Rattus norvegicus)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol]
(Sus scrofa)
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