Reactome | K63polyUb-RIPK1 is deubiquitinated

K63polyUb-RIPK1 is deubiquitinated

Stable Identifier

R-HSA-5357845

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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K63-deubiquitination of RIP1 abolishes its ability to activate NF-kappa-B upon TNF-alpha stimulation and leads to the formation of the cytosolic caspase-8 containing complex II and subsequent apoptosis.

Literature References

PubMed ID	Title	Journal	Year
34876703	The deubiquitinase OTUD1 inhibits colonic inflammation by suppressing RIPK1-mediated NF-κB signaling Liu, M, Wu, B, Ge, Y, Wei, YG, Lu, Z, Li, H, Zhang, Y, Zhou, X, Lei, Z, Liu, CH, Cui, CP, Qiang, L, Zheng, H, Zhao, M, Peng, Z, Wang, J, Dai, H, Fu, Y, Zhang, L	Cell Mol Immunol	2022
23313255	Ubiquitin-specific protease 4 promotes TNF-?-induced apoptosis by deubiquitination of RIP1 in head and neck squamous cell carcinoma Pan, X, Zhao, W, Zhang, L, Hou, X, Wang, L	FEBS Lett.	2013
22435550	Regulation of NF-?B by deubiquitinases Harhaj, EW, Dixit, VM	Immunol. Rev.	2012
22848449	NEMO inhibits programmed necrosis in an NF?B-independent manner by restraining RIP1 Hase, H, O'Donnell, MA, Legarda, D, Ting, AT	PLoS ONE	2012
24098568	CYLD deubiquitinates RIP1 in the TNF?-induced necrosome to facilitate kinase activation and programmed necrosis McQuade, T, Chan, FK, Moquin, DM	PLoS ONE	2013
35941131	OTUD1 deubiquitinase regulates NF-κB- and KEAP1-mediated inflammatory responses and reactive oxygen species-associated cell death pathways Sawasaki, T, Komakura, K, Hosomi, S, Takahashi, H, Tsuruta, D, Shiota, M, Tokunaga, F, Shimizu, K, Oikawa, D, Kosako, H, Wanibuchi, H, Gi, M	Cell Death Dis	2022
22179575	De-ubiquitinating protease USP2a targets RIP1 and TRAF2 to mediate cell death by TNF AbuAli, G, Mahul-Mellier, AL, Pazarentzos, E, Grimm, S, Datler, C, Lin, B, Iwasawa, R	Cell Death Differ.	2012
19910467	Ubiquitin-specific peptidase 21 inhibits tumor necrosis factor alpha-induced nuclear factor kappaB activation via binding to and deubiquitinating receptor-interacting protein 1 Cao, G, Xu, G, Gu, X, Wang, H, Shi, Y, Tan, X, Sun, W, Zhang, T, Yang, J, Qin, J, Burlingame, S	J. Biol. Chem.	2010
18178551	NF-kappaB suppression by the deubiquitinating enzyme Cezanne: a novel negative feedback loop in pro-inflammatory signaling Evans, PC, Rawlinson, L, Chaudhury, H, Enesa, K, Zakkar, M, Luong, le A, Dean, JL, Haskard, DO, Mason, JC	J. Biol. Chem.	2008