Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
aminocarboxypropyl EEF2 [cytosol]
Stable Identifier
R-HSA-5358478
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Icon
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Gamma carboxylation, hypusine formation and arylsulfatase activation (Homo sapiens)
Synthesis of diphthamide-EEF2 (Homo sapiens)
DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Homo sapiens)
aminocarboxypropyl EEF2 [cytosol] (Homo sapiens)
DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Homo sapiens)
aminocarboxypropyl EEF2 [cytosol] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
23971743
The biosynthesis and biological function of diphthamide
Su, X
,
Lin, Z
,
Lin, H
Crit. Rev. Biochem. Mol. Biol.
2013
15485916
Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2
Leppla, SH
,
Liu, S
,
Kuremsky, JG
,
Fink, GR
,
Milne, GT
Mol. Cell. Biol.
2004
External Reference Information
External Reference
UniProt:P13639 EEF2
Gene Names
EEF2, EF2
Chain
initiator methionine:1, chain:2-858
Reference Genes
BioGPS Gene:1938 EEF2
COSMIC (genes):EEF2 EEF2
CTD Gene:1938 EEF2
dbSNP Gene:1938 EEF2
ENSEMBL:ENSG00000167658 EEF2
HGNC:3214 EEF2
KEGG Gene (Homo sapiens):1938 EEF2
Monarch:1938 EEF2
NCBI Gene:1938 EEF2
OMIM:130610 EEF2
UCSC:P13639 EEF2
Reference Transcript
RefSeq:NM_001961.3 EEF2
Other Identifiers
0002760010
11715781_a_at
11715782_a_at
11715783_x_at
11748763_a_at
11748764_x_at
11751022_x_at
11757678_s_at
16867212
18671261
18671262
18671263
18671264
18671265
18671266
18671267
18671268
18671269
18671270
18671271
18671273
18671274
18671275
18671276
1938
200094_PM_s_at
200094_s_at
204102_s_at
36587_at
3846539
3846540
3846541
3846542
3846543
3846544
3846545
3846548
3846549
3846551
3846553
3846555
3846556
3846557
3846559
3846561
3846562
3846563
3846564
3846565
3846567
3846568
3846569
3846570
8032730
A_24_P87763
GE60349
GO:0000166
GO:0002039
GO:0002244
GO:0002376
GO:0002931
GO:0003009
GO:0003674
GO:0003723
GO:0003746
GO:0003924
GO:0005515
GO:0005525
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005737
GO:0005829
GO:0005840
GO:0005844
GO:0005886
GO:0006412
GO:0006414
GO:0006810
GO:0006950
GO:0007568
GO:0008092
GO:0008097
GO:0008135
GO:0008150
GO:0008283
GO:0009058
GO:0014009
GO:0016020
GO:0016192
GO:0016235
GO:0019843
GO:0019899
GO:0019901
GO:0030154
GO:0031410
GO:0032355
GO:0032991
GO:0034641
GO:0034774
GO:0034976
GO:0035914
GO:0042493
GO:0042542
GO:0042788
GO:0043022
GO:0043167
GO:0043226
GO:0043312
GO:0045121
GO:0045202
GO:0045296
GO:0045471
GO:0045727
GO:0048856
GO:0051015
GO:0051593
GO:0070062
GO:1904813
GO:1990416
GO:1990904
GO:2000767
HMNXSV003054355
ILMN_1738383
PH_hs_0004308
TC19001054.hg
X51466_at
g4503482_3p_a_at
Participates
as an output of
DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Homo sapiens)
as an input of
DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Homo sapiens)
Other forms of this molecule
EEF2 [ficolin-1-rich granule lumen]
EEF2 [extracellular region]
EEF2 [secretory granule lumen]
Me-diphthine EEF2 [cytosol]
nascent EEF2 [cytosol]
diphthine EEF2 [cytosol]
EEF2 [cytosol]
ADP-ribo-EEF2 [cytosol]
Me3K525-EEF2 [cytosol]
Inferred To
Homologues of aminocarboxypropyl EEF2 [cytosol]
(Danio rerio)
eef2l2 [cytosol]
(Danio rerio)
Eef2 [cytosol]
(Mus musculus)
Eef2 [cytosol]
(Rattus norvegicus)
eef-2 [cytosol]
(Caenorhabditis elegans)
EFT2 [cytosol]
(Saccharomyces cerevisiae)
EEF2 [cytosol]
(Bos taurus)
EEF2 [cytosol]
(Canis familiaris)
EEF2 [cytosol]
(Gallus gallus)
EEF2 [cytosol]
(Sus scrofa)
eft201 [cytosol]
(Schizosaccharomyces pombe)
aminocarboxypropyl EEF2 [cytosol]
(Plasmodium falciparum)
aminocarboxypropyl EEF2 [cytosol]
(Xenopus tropicalis)
efbA [cytosol]
(Dictyostelium discoideum)
eEF2 [cytosol]
(Drosophila melanogaster)
eef2b [cytosol]
(Danio rerio)
Modified Residues
Name
modified L-histidine residue (2-(3-amino-3-carboxypropyl)-L-histidine zwitterion residue) at 715
Coordinate
715
Modification
2-(3-amino-3-carboxypropyl)-L-histidine zwitterion residue
PsiMod Name
modified L-histidine residue
PsiMod Definition
A protein modification that modifies an L-histidine residue.
Cross References
RefSeq
NP_001952.1
Guide to Pharmacology - Targets
2756
OpenTargets
ENSG00000167658
HPA
ENSG00000167658-EEF2
GeneCards
P13639
Ensembl
ENST00000309311
,
ENSP00000307940
,
ENSG00000167658
PRO
P13639
Pharos - Targets
P13639
GlyGen
P13639
Orphanet
22496
HMDB Protein
HMDBP02947
PDB
6Z6M
,
6D9J
,
6Z6N
,
4V6X
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
3
UniProt:Q9NRI5 DISC1
0.553
2
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.527
2
UniProt:Q16539 MAPK14
7
MAPK14 [secretory granule lumen]
(R-HSA-6803300)
MAPK14 [extracellular region]
(R-HSA-6806453)
MAPK14 [ficolin-1-rich granule lumen]
(R-HSA-6803280)
MAPK14 [nucleoplasm]
(R-HSA-446223)
MAPK14 [cytosol]
(R-HSA-428933)
p-T180,Y182-MAPK14 [cytosol]
(R-HSA-428935)
p-T180,Y182-MAPK14 [nucleoplasm]
(R-HSA-446227)
0.527
2
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.527
3
UniProt:Q99714 HSD17B10
1
HSD17B10 [mitochondrial matrix]
(R-HSA-70831)
0.499
3
© 2022
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text