Reactome | aminocarboxypropyl EEF2 [cytosol]

aminocarboxypropyl EEF2 [cytosol]

Stable Identifier

R-HSA-5358478

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

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Literature References

PubMed ID	Title	Journal	Year
23971743	The biosynthesis and biological function of diphthamide Su, X, Lin, Z, Lin, H	Crit. Rev. Biochem. Mol. Biol.	2013
15485916	Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2 Leppla, SH, Liu, S, Kuremsky, JG, Fink, GR, Milne, GT	Mol. Cell. Biol.	2004

External Reference Information

External Reference

UniProt:P13639 EEF2

Gene Names

EEF2, EF2

Chain

initiator methionine:, chain:2-858

Reference Genes

BioGPS Gene:1938 EEF2

COSMIC (genes):EEF2 EEF2

CTD Gene:1938 EEF2

dbSNP Gene:1938 EEF2

ENSEMBL:ENSG00000167658 EEF2

HGNC:3214 EEF2

KEGG:hsa:1938 EEF2

Monarch:1938 EEF2

NCBI Gene:1938 EEF2

OMIM:130610 EEF2

UCSC:P13639 EEF2

Reference Transcript

RefSeq:NM_001961.3 EEF2

Other Identifiers

11715781_a_at

11715782_a_at

11715783_x_at

11748763_a_at

11748764_x_at

11751022_x_at

11757678_s_at

16651415

16651417

16651419

16651421

16651423

16651425

16651431

16651433

16651435

16651439

16651441

16651443

16651445

16651461

16651463

16651465

16651467

16651469

16651471

16651473

16651475

16651477

16651485

16651487

16867212

16867229

18671261

18671262

18671263

18671264

18671265

18671266

18671267

18671268

18671269

18671270

18671271

18671272

18671273

18671274

18671275

18671276

1938

200094_PM_s_at

200094_s_at

204102_PM_s_at

204102_s_at

36587_at

3846539

3846540

3846541

3846542

3846543

3846544

3846545

3846546

3846547

3846548

3846549

3846550

3846551

3846552

3846553

3846554

3846555

3846556

3846557

3846558

3846559

3846561

3846562

3846563

3846564

3846565

3846566

3846567

3846568

3846569

3846570

8032730

8032749

A_21_P0000277

A_24_P87763

GE60349

GO:0002244

GO:0003723

GO:0003746

GO:0003824

GO:0003924

GO:0005515

GO:0005525

GO:0005576

GO:0005634

GO:0005737

GO:0005829

GO:0005840

GO:0005886

GO:0006412

GO:0006414

GO:0016020

GO:0016235

GO:0016787

GO:0019901

GO:0030154

GO:0034774

GO:0043022

GO:0043226

GO:0045182

GO:0045202

GO:0045296

GO:0045727

GO:0070062

GO:1904813

GO:1990904

HMNXSV003006939

HMNXSV003054355

ILMN_1738383

PH_hs_0004308

RNA33775|snoRNA_scaRNA_371_66

TC19001054.hg

TC19001055.hg

X51466_at

g4503482_3p_a_at

Participates

as an output of

DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Homo sapiens)

as an input of

DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Homo sapiens)

Other forms of this molecule

EEF2 [ficolin-1-rich granule lumen]

EEF2 [extracellular region]

EEF2 [secretory granule lumen]

EEF2 [cytosol]

Me-diphthine EEF2 [cytosol]

nascent EEF2 [cytosol]

diphthine EEF2 [cytosol]

ADP-ribo-EEF2 [cytosol]

Me3K525-EEF2 [cytosol]

Inferred To

eef2 [cytosol] (Xenopus tropicalis)

EEF2 [cytosol] (Canis familiaris)

EEF2 [cytosol] (Gallus gallus)

aminocarboxypropyl EEF2 [cytosol] (Bos taurus)

aminocarboxypropyl EEF2 [cytosol] (Caenorhabditis elegans)

aminocarboxypropyl EEF2 [cytosol] (Danio rerio)

aminocarboxypropyl EEF2 [cytosol] (Dictyostelium discoideum)

aminocarboxypropyl EEF2 [cytosol] (Drosophila melanogaster)

aminocarboxypropyl EEF2 [cytosol] (Mus musculus)

aminocarboxypropyl EEF2 [cytosol] (Plasmodium falciparum)

aminocarboxypropyl EEF2 [cytosol] (Rattus norvegicus)

aminocarboxypropyl EEF2 [cytosol] (Saccharomyces cerevisiae)

aminocarboxypropyl EEF2 [cytosol] (Schizosaccharomyces pombe)

aminocarboxypropyl EEF2 [cytosol] (Sus scrofa)

Modified Residues

Name

modified L-histidine residue (2-(3-amino-3-carboxypropyl)-L-histidine zwitterion residue) at 715

Coordinate

715

Modification

2-(3-amino-3-carboxypropyl)-L-histidine zwitterion residue

PsiMod Name

modified L-histidine residue

PsiMod Definition

A protein modification that modifies an L-histidine residue.

Cross References

Guide to Pharmacology - Targets

2756

OpenTargets

ENSG00000167658

ENSEMBL

ENSP00000307940, ENSG00000167658, ENST00000309311

HPA

ENSG00000167658-EEF2

GeneCards

EEF2

PRO

P13639

Pharos - Targets

P13639

Orphanet

EEF2

GlyGen

P13639

HMDB Protein

HMDBP02947

PDB

6Z6M, 8Y0X, 8XSX, 8Y0W, 6D9J, 4V6X, 6Z6N

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	21
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.569	8
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:Q9NRI5 DISC1			0.553	2
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:P59665 DEFA1	9	DEFA1(1-94) [Golgi lumen] (R-HSA-1467215) DEFA1(20-94) [Golgi lumen] (R-HSA-1467282) DEFA1(66-94) [Golgi lumen] (R-HSA-975663) DEFA1(20-65) [Golgi lumen] (R-HSA-8864970) DEFA1(66-94) [extracellular region] (R-HSA-1461998) DEFA1(66-94) [azurophil granule lumen] (R-HSA-1470038) DEFA1(65-94) [extracellular region] (R-HSA-1462022) omega-N-(ADP-ribosyl)-L-arginine-DEFA1(65-94) [extracellular region] (R-HSA-1972397) DEFA1(65-94) [azurophil granule lumen] (R-HSA-1470053)	0.527	2
UniProt:Q16539 MAPK14	7	p-T180,Y182-MAPK14 [nucleoplasm] (R-HSA-446227) p-T180,Y182-MAPK14 [cytosol] (R-HSA-428935) MAPK14 [cytosol] (R-HSA-428933) MAPK14 [nucleoplasm] (R-HSA-446223) MAPK14 [ficolin-1-rich granule lumen] (R-HSA-6803280) MAPK14 [extracellular region] (R-HSA-6806453) MAPK14 [secretory granule lumen] (R-HSA-6803300)	0.527	2
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.527	2
UniProt:Q99714 HSD17B10	1	HSD17B10 [mitochondrial matrix] (R-HSA-70831)	0.499	3

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