Diphthamide synthesis proceeds in four steps: the transfer of 3 amino 3 carboxypropyl group from S adenosylmethionine to histidine 715 of EEF2, the addition of four methyl groups to the 3 amino 3 carboxypropyl moiety, the demethylation of the methylated carboxylate group to form diphthine, and the amidation of the diphthine carboxyl group (Liu et al. 2004; Lin et al. 2014; Schaffrath et al. 2014; Su et al. 2013; Uthman et al. 2013).
Howard, JB, Bodley, JW, Van Ness, BG
Schaffrath, R, Stark, MJ, Klassen, R, Abdel-Fattah Mohamed, W
Uthman, S, Schaffrath, R, Stark, MJ, Liu, S, ten Have, S, Scheidt, V, Giorgini, F, Bär, C
Su, X, Lin, Z, Lin, H
Chen, W, Ci, B, Zhang, S, Su, X, Lin, Z, Lin, H
Pappenheimer, AM
Collier, RJ
Leppla, SH, Liu, S, Kuremsky, JG, Fink, GR, Milne, GT
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