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SYVN1 dimer [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-5362361
Type
Complex
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Hh mutants abrogate ligand secretion (Homo sapiens)
Hh mutants are degraded by ERAD (Homo sapiens)
Hh processing variants are recruited to SEL1:SYVN at the ER membrane (Homo sapiens)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
SYVN1 dimer [endoplasmic reticulum membrane] (Homo sapiens)
SHH processing variants:ERLEC:OS9:SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
SYVN1 dimer [endoplasmic reticulum membrane] (Homo sapiens)
Hh processing variants are translocated to the cytosol in a VCP-dependent manner (Homo sapiens)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
SYVN1 dimer [endoplasmic reticulum membrane] (Homo sapiens)
ub-SHH processing variants:ERLEC:OS9:SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
SYVN1 dimer [endoplasmic reticulum membrane] (Homo sapiens)
Hh processing variants are ubiquitinated (Homo sapiens)
SHH processing variants:ERLEC:OS9:SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
SYVN1 dimer [endoplasmic reticulum membrane] (Homo sapiens)
ub-SHH processing variants:ERLEC:OS9:SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
SYVN1 dimer [endoplasmic reticulum membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog ligand biogenesis (Homo sapiens)
C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Homo sapiens)
C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
SYVN1 dimer [endoplasmic reticulum membrane] (Homo sapiens)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
SYVN1 dimer [endoplasmic reticulum membrane] (Homo sapiens)
SYVN1 ubiquitinates Hh C-terminal fragments (Homo sapiens)
C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
SYVN1 dimer [endoplasmic reticulum membrane] (Homo sapiens)
SYVN1 dimer [endoplasmic reticulum membrane] (Homo sapiens)
ub-C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
SYVN1 dimer [endoplasmic reticulum membrane] (Homo sapiens)
VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Homo sapiens)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
SYVN1 dimer [endoplasmic reticulum membrane] (Homo sapiens)
ub-C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
SYVN1 dimer [endoplasmic reticulum membrane] (Homo sapiens)
Participants
components
x 2
SYVN1(1-617) [endoplasmic reticulum membrane]
(Homo sapiens)
Participates
as a component of
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
Inferred To
SYVN1 dimer [endoplasmic reticulum membrane]
(Bos taurus)
SYVN1 dimer [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
SYVN1 dimer [endoplasmic reticulum membrane]
(Canis familiaris)
SYVN1 dimer [endoplasmic reticulum membrane]
(Danio rerio)
SYVN1 dimer [endoplasmic reticulum membrane]
(Dictyostelium discoideum)
SYVN1 dimer [endoplasmic reticulum membrane]
(Drosophila melanogaster)
SYVN1 dimer [endoplasmic reticulum membrane]
(Gallus gallus)
SYVN1 dimer [endoplasmic reticulum membrane]
(Mus musculus)
SYVN1 dimer [endoplasmic reticulum membrane]
(Rattus norvegicus)
SYVN1 dimer [endoplasmic reticulum membrane]
(Schizosaccharomyces pombe)
SYVN1 dimer [endoplasmic reticulum membrane]
(Sus scrofa)
SYVN1 dimer [endoplasmic reticulum membrane]
(Xenopus tropicalis)
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