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OS9/ERLEC1 [endoplasmic reticulum quality control compartment]
Stable Identifier
R-HSA-5362377
Type
Set [DefinedSet]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
,
endoplasmic reticulum quality control compartment
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Hh mutants abrogate ligand secretion (Homo sapiens)
Hh mutants are degraded by ERAD (Homo sapiens)
Hh processing variants are recruited to SEL1:SYVN at the ER membrane (Homo sapiens)
SHH processing variants:ERLEC:OS9:SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
SHH processing variants:OS9/ERLEC1 [endoplasmic reticulum lumen] (Homo sapiens)
OS9/ERLEC1 [endoplasmic reticulum quality control compartment] (Homo sapiens)
SHH processing variants:OS9/ERLEC1 [endoplasmic reticulum lumen] (Homo sapiens)
OS9/ERLEC1 [endoplasmic reticulum quality control compartment] (Homo sapiens)
Hh processing variants are translocated to the cytosol in a VCP-dependent manner (Homo sapiens)
OS9/ERLEC1 [endoplasmic reticulum quality control compartment] (Homo sapiens)
ub-SHH processing variants:ERLEC:OS9:SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
ub-SHH processing variants:OS9/ERLEC1 [endoplasmic reticulum lumen] (Homo sapiens)
OS9/ERLEC1 [endoplasmic reticulum quality control compartment] (Homo sapiens)
Hh processing variants are ubiquitinated (Homo sapiens)
SHH processing variants:ERLEC:OS9:SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
SHH processing variants:OS9/ERLEC1 [endoplasmic reticulum lumen] (Homo sapiens)
OS9/ERLEC1 [endoplasmic reticulum quality control compartment] (Homo sapiens)
ub-SHH processing variants:ERLEC:OS9:SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
ub-SHH processing variants:OS9/ERLEC1 [endoplasmic reticulum lumen] (Homo sapiens)
OS9/ERLEC1 [endoplasmic reticulum quality control compartment] (Homo sapiens)
Hh processing variants bind lectins (Homo sapiens)
OS9/ERLEC1 [endoplasmic reticulum quality control compartment] (Homo sapiens)
SHH processing variants:OS9/ERLEC1 [endoplasmic reticulum lumen] (Homo sapiens)
OS9/ERLEC1 [endoplasmic reticulum quality control compartment] (Homo sapiens)
Disorders of transmembrane transporters (Homo sapiens)
ABC transporter disorders (Homo sapiens)
Defective CFTR causes cystic fibrosis (Homo sapiens)
CFTR F508del binds components of the ERAD machinery for ubiquitination and degradation (Homo sapiens)
CFTR F508del:ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
OS9/ERLEC1 [endoplasmic reticulum quality control compartment] (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
OS9/ERLEC1 [endoplasmic reticulum quality control compartment] (Homo sapiens)
RNF5 and RNF185 ubiquitinate CFTR F508del (Homo sapiens)
CFTR F508del:ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
OS9/ERLEC1 [endoplasmic reticulum quality control compartment] (Homo sapiens)
ub-CFTR F508del:ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
OS9/ERLEC1 [endoplasmic reticulum quality control compartment] (Homo sapiens)
VCP-catalyzed ATP hydrolysis promotes the translocation of CFTR F508del into the cytosol (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
OS9/ERLEC1 [endoplasmic reticulum quality control compartment] (Homo sapiens)
ub-CFTR F508del:ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
OS9/ERLEC1 [endoplasmic reticulum quality control compartment] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog ligand biogenesis (Homo sapiens)
C-terminal Hh fragments are bound by lectins (Homo sapiens)
C-terminal Hh fragments:OS9/ERLEC1 [endoplasmic reticulum lumen] (Homo sapiens)
OS9/ERLEC1 [endoplasmic reticulum quality control compartment] (Homo sapiens)
OS9/ERLEC1 [endoplasmic reticulum quality control compartment] (Homo sapiens)
C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Homo sapiens)
C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
C-terminal Hh fragments:OS9/ERLEC1 [endoplasmic reticulum lumen] (Homo sapiens)
OS9/ERLEC1 [endoplasmic reticulum quality control compartment] (Homo sapiens)
C-terminal Hh fragments:OS9/ERLEC1 [endoplasmic reticulum lumen] (Homo sapiens)
OS9/ERLEC1 [endoplasmic reticulum quality control compartment] (Homo sapiens)
SYVN1 ubiquitinates Hh C-terminal fragments (Homo sapiens)
C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
C-terminal Hh fragments:OS9/ERLEC1 [endoplasmic reticulum lumen] (Homo sapiens)
OS9/ERLEC1 [endoplasmic reticulum quality control compartment] (Homo sapiens)
ub-C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
OS9/ERLEC1 [endoplasmic reticulum quality control compartment] (Homo sapiens)
VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Homo sapiens)
OS9/ERLEC1 [endoplasmic reticulum quality control compartment] (Homo sapiens)
ub-C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
OS9/ERLEC1 [endoplasmic reticulum quality control compartment] (Homo sapiens)
Transport of small molecules (Homo sapiens)
ABC-family proteins mediated transport (Homo sapiens)
CFTR binds components of the ERAD machinery for ubiquitination and degradation (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
OS9/ERLEC1 [endoplasmic reticulum quality control compartment] (Homo sapiens)
misfolded CFTR:ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
OS9/ERLEC1 [endoplasmic reticulum quality control compartment] (Homo sapiens)
RNF5 and RNF185 ubiquitinate misfolded CFTR (Homo sapiens)
Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
OS9/ERLEC1 [endoplasmic reticulum quality control compartment] (Homo sapiens)
misfolded CFTR:ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
OS9/ERLEC1 [endoplasmic reticulum quality control compartment] (Homo sapiens)
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
OS9/ERLEC1 [endoplasmic reticulum quality control compartment] (Homo sapiens)
Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
OS9/ERLEC1 [endoplasmic reticulum quality control compartment] (Homo sapiens)
Participants
members
ERLEC1 [endoplasmic reticulum quality control compartment]
(Homo sapiens)
OS9 [endoplasmic reticulum membrane]
(Homo sapiens)
Participates
as an input of
C-terminal Hh fragments are bound by lectins (Homo sapiens)
Hh processing variants bind lectins (Homo sapiens)
as a component of
C-terminal Hh fragments:OS9/ERLEC1 [endoplasmic reticulum lumen] (Homo sapiens)
ub-C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
SHH processing variants:OS9/ERLEC1 [endoplasmic reticulum lumen] (Homo sapiens)
ub-SHH processing variants:OS9/ERLEC1 [endoplasmic reticulum lumen] (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
as an output of
VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Homo sapiens)
Hh processing variants are translocated to the cytosol in a VCP-dependent manner (Homo sapiens)
Inferred To
Dmel\CG6766 [endoplasmic reticulum quality control compartment]
(Drosophila melanogaster)
OS9/ERLEC1 [endoplasmic reticulum quality control compartment]
(Bos taurus)
OS9/ERLEC1 [endoplasmic reticulum quality control compartment]
(Caenorhabditis elegans)
OS9/ERLEC1 [endoplasmic reticulum quality control compartment]
(Canis familiaris)
OS9/ERLEC1 [endoplasmic reticulum quality control compartment]
(Danio rerio)
OS9/ERLEC1 [endoplasmic reticulum quality control compartment]
(Dictyostelium discoideum)
OS9/ERLEC1 [endoplasmic reticulum quality control compartment]
(Mus musculus)
OS9/ERLEC1 [endoplasmic reticulum quality control compartment]
(Rattus norvegicus)
OS9/ERLEC1 [endoplasmic reticulum quality control compartment]
(Schizosaccharomyces pombe)
OS9/ERLEC1 [endoplasmic reticulum quality control compartment]
(Sus scrofa)
OS9/ERLEC1 [endoplasmic reticulum quality control compartment]
(Xenopus tropicalis)
ERLEC1 [endoplasmic reticulum quality control compartment]
(Gallus gallus)
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