Proteomic studies show that the C-termini of SHH and IHH are N-glycosylated (Liu et al, 2005). A N278A mutant of SHH does not undergo cholesterol-mediated autoproteolysis suggesting that glycosylation is a prerequisite for this processing step (Huang et al, 2013).
Ye, Y, Chu, YR, Hsiao, HT, Huang, CH, Chen, X
Monroe, ME, Smith, RD, Qian, WJ, Moore, RJ, Camp, DG, Gritsenko, MA, Liu, T
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