Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
CHOL-N-palmitoyl-L-cysteine-SHH(24-197) [plasma membrane]
Stable Identifier
R-HSA-5362407
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Sonic hedgehog protein N product, SHH, SHH_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Developmental Cell Lineages (Homo sapiens)
Developmental Lineage of Pancreatic Acinar Cells (Homo sapiens)
Definitive endoderm cell produces ventral foregut endoderm cell (Homo sapiens)
ventral foregut endoderm cell (Homo sapiens)
CHOL-N-palmitoyl-L-cysteine-SHH(24-197) [plasma membrane] (Homo sapiens)
Ventral foregut endoderm cell produces primary multipotent pancreatic progenitor cell (Homo sapiens)
ventral foregut endoderm cell (Homo sapiens)
CHOL-N-palmitoyl-L-cysteine-SHH(24-197) [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog ligand biogenesis (Homo sapiens)
Hh-Np traffics to the plasma membrane (Homo sapiens)
Hh-Np [plasma membrane] (Homo sapiens)
CHOL-N-palmitoyl-L-cysteine-SHH(24-197) [plasma membrane] (Homo sapiens)
Release of Hh-Np from the secreting cell (Homo sapiens)
Hh-Np binds GPC5 (Homo sapiens)
Hh-Np [plasma membrane] (Homo sapiens)
CHOL-N-palmitoyl-L-cysteine-SHH(24-197) [plasma membrane] (Homo sapiens)
Hh-Np:GPI-GPC5 [plasma membrane] (Homo sapiens)
Hh-Np [plasma membrane] (Homo sapiens)
CHOL-N-palmitoyl-L-cysteine-SHH(24-197) [plasma membrane] (Homo sapiens)
Hh-Np binds SCUBE2 in the extracellular region to promote long-range signalling (Homo sapiens)
Hh-Np:DISP2 [plasma membrane] (Homo sapiens)
Hh-Np [plasma membrane] (Homo sapiens)
CHOL-N-palmitoyl-L-cysteine-SHH(24-197) [plasma membrane] (Homo sapiens)
Hh-Np binds to DISP2 (Homo sapiens)
Hh-Np [plasma membrane] (Homo sapiens)
CHOL-N-palmitoyl-L-cysteine-SHH(24-197) [plasma membrane] (Homo sapiens)
Hh-Np:DISP2 [plasma membrane] (Homo sapiens)
Hh-Np [plasma membrane] (Homo sapiens)
CHOL-N-palmitoyl-L-cysteine-SHH(24-197) [plasma membrane] (Homo sapiens)
Hh-Np is cleaved by ADAM17 to promote ligand shedding (Homo sapiens)
Hh-Np [plasma membrane] (Homo sapiens)
CHOL-N-palmitoyl-L-cysteine-SHH(24-197) [plasma membrane] (Homo sapiens)
NOTUM releases Hh-Np:GPC5 from the plasma membrane (Homo sapiens)
Hh-Np:GPI-GPC5 [plasma membrane] (Homo sapiens)
Hh-Np [plasma membrane] (Homo sapiens)
CHOL-N-palmitoyl-L-cysteine-SHH(24-197) [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15465 SHH
Gene Names
SHH
Chain
signal peptide:1-23, chain:24-462, chain:24-197
Reference Genes
BioGPS Gene:6469 SHH
COSMIC (genes):SHH SHH
CTD Gene:6469 SHH
dbSNP Gene:6469 SHH
ENSEMBL:ENSG00000164690 SHH
HGNC:10848 SHH
KEGG:hsa:6469 SHH
Monarch:6469 SHH
NCBI Gene:6469 SHH
OMIM:600725 SHH
UCSC:Q15465 SHH
Reference Transcript
RefSeq:NM_000193.3 SHH
Other Identifiers
11738265_at
17064810
207586_PM_at
207586_at
236263_PM_at
236263_at
3081218
3081219
3081220
3081221
3081222
3081223
3081224
3081225
3081226
3081227
3081229
3081230
3081231
31724_at
59360_at
6469
70121_at
8144078
A_23_P111657
GE619667
GO:0000122
GO:0000139
GO:0001525
GO:0001569
GO:0001570
GO:0001656
GO:0001658
GO:0001708
GO:0001755
GO:0001822
GO:0001942
GO:0001944
GO:0001947
GO:0002052
GO:0002053
GO:0002076
GO:0002320
GO:0002376
GO:0003140
GO:0003824
GO:0004175
GO:0005113
GO:0005509
GO:0005515
GO:0005539
GO:0005576
GO:0005615
GO:0005783
GO:0005788
GO:0005789
GO:0005794
GO:0005829
GO:0005886
GO:0006355
GO:0006508
GO:0006606
GO:0006629
GO:0006886
GO:0006897
GO:0006913
GO:0007010
GO:0007163
GO:0007224
GO:0007267
GO:0007275
GO:0007368
GO:0007389
GO:0007398
GO:0007405
GO:0007411
GO:0007417
GO:0007418
GO:0007442
GO:0007507
GO:0007519
GO:0007596
GO:0008209
GO:0008233
GO:0008270
GO:0008283
GO:0008284
GO:0009880
GO:0009888
GO:0009949
GO:0009952
GO:0009953
GO:0009986
GO:0010463
GO:0010467
GO:0010468
GO:0010628
GO:0010629
GO:0012501
GO:0014003
GO:0014706
GO:0014856
GO:0014858
GO:0014902
GO:0016015
GO:0016020
GO:0016192
GO:0016477
GO:0016539
GO:0016540
GO:0016740
GO:0016787
GO:0021513
GO:0021522
GO:0021794
GO:0021871
GO:0021904
GO:0021924
GO:0021930
GO:0021940
GO:0021978
GO:0022414
GO:0023052
GO:0030154
GO:0030162
GO:0030177
GO:0030178
GO:0030182
GO:0030312
GO:0030323
GO:0030324
GO:0030326
GO:0030336
GO:0030539
GO:0030850
GO:0030878
GO:0030900
GO:0030901
GO:0030902
GO:0031012
GO:0031016
GO:0031069
GO:0032435
GO:0033077
GO:0033085
GO:0033089
GO:0033092
GO:0034244
GO:0034504
GO:0035115
GO:0035116
GO:0035295
GO:0036484
GO:0042098
GO:0042127
GO:0042130
GO:0042177
GO:0042307
GO:0042475
GO:0042476
GO:0042481
GO:0042733
GO:0043010
GO:0043066
GO:0043226
GO:0043237
GO:0043369
GO:0043588
GO:0045059
GO:0045060
GO:0045109
GO:0045121
GO:0045165
GO:0045445
GO:0045596
GO:0045665
GO:0045880
GO:0045893
GO:0045944
GO:0046632
GO:0046638
GO:0046639
GO:0046872
GO:0048018
GO:0048468
GO:0048513
GO:0048538
GO:0048546
GO:0048557
GO:0048568
GO:0048589
GO:0048598
GO:0048617
GO:0048643
GO:0048645
GO:0048646
GO:0048663
GO:0048706
GO:0048708
GO:0048709
GO:0048711
GO:0048714
GO:0048745
GO:0048754
GO:0048839
GO:0048856
GO:0048859
GO:0048864
GO:0048870
GO:0050673
GO:0050679
GO:0050793
GO:0051146
GO:0051155
GO:0051604
GO:0051781
GO:0060020
GO:0060021
GO:0060070
GO:0060173
GO:0060174
GO:0060251
GO:0060425
GO:0060428
GO:0060438
GO:0060439
GO:0060441
GO:0060442
GO:0060445
GO:0060447
GO:0060458
GO:0060459
GO:0060463
GO:0060484
GO:0060516
GO:0060523
GO:0060662
GO:0060664
GO:0060684
GO:0060685
GO:0060738
GO:0060767
GO:0060768
GO:0060769
GO:0060782
GO:0060783
GO:0060840
GO:0060916
GO:0061053
GO:0061189
GO:0062023
GO:0071285
GO:0071542
GO:0072089
GO:0072091
GO:0072136
GO:0072205
GO:0090090
GO:0090162
GO:0090370
GO:0097152
GO:0097190
GO:0097264
GO:0098528
GO:0098772
GO:0140096
GO:0140853
GO:1900180
GO:1904339
GO:1905327
GO:2000062
GO:2000063
GO:2000357
GO:2000358
GO:2000729
GO:2001054
HMNXSV003038694
Hs.164537.0.A1_3p_at
ILMN_1652693
PH_hs_0006769
PH_hs_0009949
TC07002064.hg
g4506938_3p_at
p28827
p33937
Participates
as a component of
CHOL-N-palmitoyl-L-cysteine-SHH(24-197):Disp2 [plasma membrane] (Homo sapiens)
as an input of
mouse Disp2 binds SHH N-terminal fragment (Homo sapiens)
as a member of
Hh-Np [plasma membrane] (Homo sapiens)
as a protein marker of
ventral foregut endoderm cell (Homo sapiens)
Other forms of this molecule
CHOL-N-palmitoyl-L-cysteine-SHH(24-197) [extracellular region]
CHOL-N-palmitoyl-L-cysteine-SHH(24-197) [endoplasmic reticulum lumen]
ub-N4glycoAsn-SHH(198-462) [endoplasmic reticulum lumen]
ub-N4glycoAsn-SHH(198-462) [cytosol]
2xHC-SHH(24-462) [endoplasmic reticulum lumen]
N4glycoAsn-SHH(198-462) [endoplasmic reticulum lumen]
CHOL-SHH(24-197) [endoplasmic reticulum lumen]
N4glycoAsn-2xHC-SHH(24-462) [endoplasmic reticulum lumen]
SHH(24-462) C198S [endoplasmic reticulum lumen]
SHH(24-462) W117G [endoplasmic reticulum lumen]
SHH(24-462) H374R [endoplasmic reticulum lumen]
SHH(24-462) L382P [endoplasmic reticulum lumen]
SHH(24-462) A383T [endoplasmic reticulum lumen]
SHH(24-462) A376D [endoplasmic reticulum lumen]
SHH(24-462) P377S [endoplasmic reticulum lumen]
SHH(24-462) R381P [endoplasmic reticulum lumen]
SHH(24-462) A373T [endoplasmic reticulum lumen]
SHH(24-462) C198F [endoplasmic reticulum lumen]
SHH(24-462) G196E [endoplasmic reticulum lumen]
SHH(24-462) G196V [endoplasmic reticulum lumen]
SHH(34-?) [extracellular region]
SHH(24-462) [endoplasmic reticulum lumen]
ub SHH(24-462) W117G [cytosol]
ub SHH(24-462) A373T [cytosol]
ub SHH(24-462) H374R [cytosol]
ub SHH(24-462) A383T [cytosol]
ub SHH(24-462) P377S [cytosol]
ub SHH(24-462) A376D [cytosol]
ub SHH(24-462) R381P [cytosol]
ub SHH(24-462) L382P [cytosol]
ub SHH(24-462) G196V [cytosol]
ub SHH(24-462) C198F [cytosol]
ub SHH(24-462) G196E [cytosol]
ub SHH(24-462) W117R [cytosol]
ub SHH(24-462) C198S [cytosol]
ub-SHH(24-462) W117R [endoplasmic reticulum lumen]
ub-SHH(24-462) W117G [endoplasmic reticulum lumen]
ub-SHH(24-462) A373T [endoplasmic reticulum lumen]
ub-SHH(24-462) L382P [endoplasmic reticulum lumen]
ub-SHH(24-462) P377S [endoplasmic reticulum lumen]
ub-SHH(24-462) A383T [endoplasmic reticulum lumen]
ub-SHH(24-462) H374R [endoplasmic reticulum lumen]
ub-SHH(24-462) R381P [endoplasmic reticulum lumen]
ub-SHH(24-462) A376D [endoplasmic reticulum lumen]
ub-SHH(24-462) C198F [endoplasmic reticulum lumen]
ub-SHH(24-462) G196E [endoplasmic reticulum lumen]
ub-SHH(24-462) G196V [endoplasmic reticulum lumen]
ub-SHH(24-462) C198S [endoplasmic reticulum lumen]
SHH(24-462) W117R [endoplasmic reticulum lumen]
Inferred To
SHH [plasma membrane]
(Canis familiaris)
CHOL-N-palmitoyl-L-cysteine-SHH(24-197) [plasma membrane]
(Bos taurus)
CHOL-N-palmitoyl-L-cysteine-SHH(24-197) [plasma membrane]
(Danio rerio)
CHOL-N-palmitoyl-L-cysteine-SHH(24-197) [plasma membrane]
(Drosophila melanogaster)
CHOL-N-palmitoyl-L-cysteine-SHH(24-197) [plasma membrane]
(Gallus gallus)
CHOL-N-palmitoyl-L-cysteine-SHH(24-197) [plasma membrane]
(Mus musculus)
CHOL-N-palmitoyl-L-cysteine-SHH(24-197) [plasma membrane]
(Rattus norvegicus)
CHOL-N-palmitoyl-L-cysteine-SHH(24-197) [plasma membrane]
(Sus scrofa)
CHOL-N-palmitoyl-L-cysteine-SHH(24-197) [plasma membrane]
(Xenopus tropicalis)
Modified Residues
Name
glycine cholesterol ester at 197
Coordinate
197
PsiMod Name
glycine cholesterol ester [MOD:00314]
PsiMod Definition
A protein modification that effectively converts a glycine residue to glycine cholesterol ester.
Name
N-palmitoyl-L-cysteine at 24
Coordinate
24
PsiMod Name
N-palmitoyl-L-cysteine [MOD:00069]
PsiMod Definition
A protein modification that effectively converts an L-cysteine residue to N-palmitoyl-L-cysteine.
Cross References
ZINC - World Drugs
SHH_HUMAN
OpenTargets
ENSG00000164690
ENSEMBL
ENSP00000297261
,
ENST00000297261
ZINC - FDA approved
SHH_HUMAN
ZINC - Substances
SHH_HUMAN
ZINC - Biogenic
SHH_HUMAN
ZINC target
Q15465
PRO
Q15465
GlyGen
Q15465
PDB
6RVD
,
7E2I
,
6PJV
,
6OEV
,
6E1H
,
7RHQ
,
7MHZ
,
6N7H
,
6N7G
,
3MXW
,
3M1N
,
6DMY
,
6RMG
,
3HO5
,
7URF
,
6N7K
ZINC - Metabolites
SHH_HUMAN
HPA
ENSG00000164690-SHH
Pharos - Targets
Q15465
Orphanet
SHH
ZINC - Predictions - Purchasable
SHH_HUMAN
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13635-1 PTCH1
0.781
11
UniProt:Q96QV1 HHIP
1
HHIP [ciliary membrane]
(R-HSA-445449)
0.691
10
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text