Reactome | VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol

VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol

Stable Identifier

R-HSA-5362459

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol

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The ATPase activity of VCP is required for the retrotranslocation of Hh-C across the ER membrane (Chen et al, 2011). Although in this pathway, the VCP hexamer is shown as part of the SEL1:SYVN1:DERL2 retrotranslocon, the details, order of events and even the full complement of protein players in this process are not known. In yeast, the VCP homologue Cdc48 is associated with two additional proteins Ufd1 and Npl4 -both of which are also conserved in mammals- and this complex interacts with several ER components including derlins and the yeast SYVN1 homologue, Hrd1 (reviewed in Vembar and Brodsky, 2009). Consistent with the yeast data, VCP interacts with DERL2 by co-immunoprecipitation in HEK293 cells (Huang et al, 2013).

Literature References

PubMed ID	Title	Journal	Year
21357747	Processing and turnover of the Hedgehog protein in the endoplasmic reticulum Jao, C, Rapoport, TA, Tang, HY, Chu, YR, Schulman, S, Huang, CH, Chen, X, Salic, A, Mueller, B, Tukachinsky, H	J. Cell Biol.	2011
23867461	Derlin2 protein facilitates HRD1-mediated retro-translocation of sonic hedgehog at the endoplasmic reticulum Ye, Y, Chu, YR, Hsiao, HT, Huang, CH, Chen, X	J. Biol. Chem.	2013
19002207	One step at a time: endoplasmic reticulum-associated degradation Vembar, SS, Brodsky, JL	Nat. Rev. Mol. Cell Biol.	2008