Reactome | K63polyUb-TANK [cytosol]

K63polyUb-TANK [cytosol]

Stable Identifier

R-HSA-5362480

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

TRAF family member-associated NF-kappa-B activator, TANK_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q92844 TANK

Gene Names

TANK, ITRAF, TRAF2

Chain

chain:1-425

Reference Genes

BioGPS Gene:10010 TANK

COSMIC (genes):TANK TANK

CTD Gene:10010 TANK

dbSNP Gene:10010 TANK

ENSEMBL:ENSG00000136560 TANK

ENSEMBL:ENSG00000136560.14 TANK

HGNC:11562 TANK

KEGG Gene (Homo sapiens):10010 TANK

Monarch:10010 TANK

NCBI Gene:10010 TANK

OMIM:603893 TANK

UCSC:Q92844 TANK

Reference Transcript

Other Identifiers

10010

11724596_s_at

11752780_a_at

11752781_s_at

11753782_a_at

207616_PM_s_at

207616_s_at

209451_PM_at

209451_at

210458_3p_s_at

210458_PM_s_at

210458_s_at

2512602

2512604

2512621

2512622

2512636

2512637

2512638

2512639

2512649

2512653

2512654

2512659

2512665

2512666

2512667

39742_at

8045933

A_14_P124419

A_23_P154306

A_24_P257108

GE61485

GO:0002376

GO:0003824

GO:0004843

GO:0005515

GO:0005737

GO:0005829

GO:0006974

GO:0007165

GO:0007249

GO:0016787

GO:0023052

GO:0031625

GO:0032481

GO:0032991

GO:0035800

GO:0036211

GO:0043124

GO:0046872

GO:0051607

GO:0060090

GO:0060337

GO:0071347

GO:0071356

GO:0071479

GO:0098542

GO:0098772

GO:0140096

GO:1902554

GO:1903003

GO:2000158

HMNXSV003026850

HMNXSV003041373

HMNXSV003045821

ILMN_1715069

ILMN_1793849

ILMN_2292387

ILMN_2372773

PH_hs_0008774

U59863_at

g13097263_3p_a_at

g13097263_3p_at

g13097263_3p_x_at

g1518017_3p_at

g4759249_3p_a_at

Participates

as a component of

Other forms of this molecule

TANK [cytosol]

Inferred To

Tank [cytosol] (Rattus norvegicus)

TANK [cytosol] (Bos taurus)

Ghost homologue of K63polyUb-TANK [cytosol] (Sus scrofa)

K63polyUb-TANK [cytosol] (Canis familiaris)

K63polyUb-TANK [cytosol] (Danio rerio)

K63polyUb-TANK [cytosol] (Gallus gallus)

K63polyUb-TANK [cytosol] (Mus musculus)

tank [cytosol] (Xenopus tropicalis)

Modified Residues

Name

ubiquitinylated lysine (K63polyUb [cytosol]) at unknown position

Modification

K63polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

XP_016858585.1, XP_016858586.1, NP_001186064.1, NP_004171.2, NP_597841.1

OpenTargets

ENSG00000136560

HPA

ENSG00000136560-TANK

GeneCards

Q92844

Ensembl

ENSP00000376505, ENST00000403609, ENST00000392749, ENSP00000259075, ENST00000259075, ENSP00000385983, ENSG00000136560

PRO

Q92844

Pharos - Targets

Q92844

PDB

1KZZ, 1L0A, 5H10

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UHD2 TBK1	4	pS-172,K48polyUb-TBK1 [cytosol] (R-HSA-3249397) p-TBK1 [cytosol] (R-HSA-9008705) p-S172-TBK1 [cytosol] (R-HSA-168379) TBK1 [cytosol] (R-HSA-166267)	0.924	14
UniProt:Q13114 TRAF3	4	TRAF3 R118W [cytosol] (R-HSA-5602321) K48polyUb-TRAF3 [cytosol] (R-HSA-936556) TRAF3 [cytosol] (R-HSA-914241) K63polyUb-TRAF3 [cytosol] (R-HSA-936402)	0.829	7
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.809	8
UniProt:Q14164 IKBKE	4	IKBKE [cytosol] (R-HSA-450225) p-S172-IKBKE [cytosol] (R-HSA-450278) p-S172-IKBKE [nucleoplasm] (R-HSA-4755521) monoSUMO1-K231-p-S172-IKBKE [nucleoplasm] (R-HSA-4755535)	0.779	4
UniProt:Q96MT8 CEP63	1	CEP63 [cytosol] (R-HSA-380267)	0.659	4
UniProt:Q13490 BIRC2	5	K63polyUb-BIRC2 [cytosol] (R-HSA-5668512) BIRC2(1-372) [cytosol] (R-HSA-202913) BIRC2(373-618) [cytosol] (R-HSA-202931) K48pUb-BIRC2 [cytosol] (R-HSA-5675479) BIRC2 [cytosol] (R-HSA-50847)	0.643	4
UniProt:P53350 PLK1	4	PLK1 [nucleoplasm] (R-HSA-156720) p-T210-PLK1 [cytosol] (R-HSA-3000318) p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) PLK1 [cytosol] (R-HSA-164603)	0.57	3
UniProt:Q92844 TANK	2	TANK [cytosol] (R-HSA-933407) K63polyUb-TANK [cytosol] (R-HSA-5362480)	0.564	3
UniProt:Q05519 SRSF11	1	SRSF11 [nucleoplasm] (R-HSA-72058)	0.556	3
UniProt:Q13625-3 TP53BP2			0.556	3
UniProt:Q9Y6K9 IKBKG	12	IKBKG D406V [cytosol] (R-HSA-5262943) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG [nucleoplasm] (R-HSA-4755413) K63polyUb-IKBKG [cytosol] (R-HSA-202530) Ub-285-IKBKG [cytosol] (R-HSA-741397) IKBKG [cytosol] (R-HSA-168108)	0.547	5
UniProt:Q13077 TRAF1	3	TRAF1 [cytosol] (R-HSA-5634163) TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.547	2
UniProt:P17362 PG029			0.524	2
UniProt:Q92574 TSC1	2	TSC1 [plasma membrane] (R-HSA-165169) TSC1 [cytosol] (R-HSA-5672338)	0.508	3
UniProt:P03495 NS1			0.508	2
UniProt:O96018 APBA3	1	APBA3 [cytosol] (R-HSA-6794262)	0.499	2
UniProt:P61956 SUMO2	6	lysyl-G93-SUMO2 [cytosol] (R-HSA-9834803) SUMO2(1-95) [nucleoplasm] (R-HSA-2990837) SUMO2 [nucleoplasm] (R-HSA-2984281) UBA2-G93-SUMO2 [nucleoplasm] (R-HSA-3730618) UBE2I-G93-SUMO2 [nucleoplasm] (R-HSA-3730625) lysyl-G93-SUMOyl-K11-SUMO2 [nucleoplasm] (R-HSA-9761546)	0.499	3