Reactome | TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4

TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4

Stable Identifier

R-HSA-5362500

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

endosome membrane, cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Toll-like Receptor Cascades (Homo sapiens)
    - Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
      - MyD88-independent TLR4 cascade (Homo sapiens)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
        
        Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) (Homo sapiens)
        
        TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Homo sapiens)

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TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4

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Upon stimulation by pathogen-associated inflammatory signals TANK associates with TRAF3 which results in K63-linked ubiquitination of TANK (Gatot JC et al. 2007). How the ubiquitination of TANK contributes to the activation of TBK1 and/or IKKepsilon remains unclear.

Literature References

PubMed ID	Title	Journal	Year
17823124	Lipopolysaccharide-mediated interferon regulatory factor activation involves TBK1-IKKepsilon-dependent Lys(63)-linked polyubiquitination and phosphorylation of TANK/I-TRAF Muraille, E, Close, P, Brown, K, Siebenlist, U, Chau, TL, Chapelle, JP, Piette, J, Warnier, M, Gatot, JS, Patrascu, F, Dejardin, E, Chariot, A, Gioia, R	J. Biol. Chem.	2007
17047224	Regulation and function of IKK and IKK-related kinases Karin, M, Hacker, H	Sci STKE	2006