Reactome | NOTUM releases Hh-Np:GPC5 from the plasma membrane

NOTUM releases Hh-Np:GPC5 from the plasma membrane

Stable Identifier

R-HSA-5362553

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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NOTUM releases Hh-Np:GPC5 from the plasma membrane

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Notum is a secreted protein with phospholipase C activity that has been implicated in promoting long range Hh signaling in Drosophila (Ayers et al, 2010; Eugster et al, 2007; Takeo et al, 2005; Han et al, 2005; Giraldez et al, 2002). Notum is thought to cleave the GPI-anchor from Dally, a Drosophila glypican, to release Hh-Dally complexes from the plasma membrane of the Hh-secreting cell (Ayers et al, 2010; Han et al, 2005), although this cleavage has not been directly demonstrated. In cultured mammalian cells, NOTUM has been shown to cleave the GPI anchor of a number of glypicans to promote their release from the plasma membrane (Traister et al, 2008).

Literature References

PubMed ID	Title	Journal	Year
12015973	HSPG modification by the secreted enzyme Notum shapes the Wingless morphogen gradient Copley, RR, Cohen, SM, Giráldez, AJ	Dev. Cell	2002
15963974	Expression of a secreted form of Dally, a Drosophila glypican, induces overgrowth phenotype by affecting action range of Hedgehog Akiyama, T, Firkus, C, Nakato, H, Aigaki, T, Takeo, S	Dev. Biol.	2005
17967162	Mammalian Notum induces the release of glypicans and other GPI-anchored proteins from the cell surface Filmus, J, Traister, A, Shi, W	Biochem. J.	2008
15647319	Drosophila glypicans Dally and Dally-like shape the extracellular Wingless morphogen gradient in the wing disc Lin, X, Yan, D, Han, C, Belenkaya, TY	Development	2005
17609110	Lipoprotein-heparan sulfate interactions in the Hh pathway Eugster, C, Mahmoud, A, Eaton, S, Panáková, D	Dev. Cell	2007
20412775	The long-range activity of Hedgehog is regulated in the apical extracellular space by the glypican Dally and the hydrolase Notum Gallet, A, Ayers, KL, Thérond, PP, Staccini-Lavenant, L	Dev. Cell	2010