Reactome | PTCD3 [mitochondrial inner membrane]

PTCD3 [mitochondrial inner membrane]

Stable Identifier

R-HSA-5368165

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

Pentatricopeptide repeat domain-containing protein 3, mitochondrial, PTCD3_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q96EY7 PTCD3

Gene Names

PTCD3, MRPS39, TRG15

Chain

transit peptide:1-37, chain:38-689

Reference Genes

BioGPS Gene:55037 PTCD3

COSMIC (genes):PTCD3 PTCD3

CTD Gene:55037 PTCD3

dbSNP Gene:55037 PTCD3

ENSEMBL:ENSG00000132300 PTCD3

ENSEMBL_homo_sapiens_GENE:ENSG00000132300.19 PTCD3

HGNC:24717 PTCD3

KEGG Gene (Homo sapiens):55037 PTCD3

Monarch:55037 PTCD3

NCBI Gene:55037 PTCD3

OMIM:614918 PTCD3

UCSC:Q96EY7 PTCD3

Reference Transcript

RefSeq:NM_017952.5 PTCD3

Other Identifiers

11743102_at

11743103_at

11743104_at

11743105_at

11746612_a_at

11758516_s_at

16882375

217895_PM_at

217895_at

228020_PM_at

228020_at

228512_PM_at

228512_at

228590_PM_at

228590_at

2491937

2491938

2491939

2491940

2491942

2491943

2491944

2491947

2491949

2491951

2491952

2491953

2491955

2491958

2491960

2491962

2491966

2491968

2491970

2491971

2491972

2491975

2491980

2491982

2491983

2491984

2491985

2491986

2491988

2491990

2491991

3843042

3843049

44629_at

45168_at

52727_at

55037

57148_at

64755_at

65342_at

75251_at

8043251

A_14_P110369

A_23_P154266

A_33_P3272808

A_33_P3290945

GE82257

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005739

GO:0005743

GO:0005763

GO:0005829

GO:0005840

GO:0005886

GO:0006417

GO:0019843

GO:0032543

GO:0043024

GO:0043226

GO:0140053

GO:1990904

HMNXSV003040901

Hs.34460.0.A1_3p_at

Hs.40421.0.A1_3p_at

Hs.7790.0.A1_3p_at

ILMN_1714424

PH_hs_0023804

TC02000520.hg

g8923669_3p_at

Participates

as a component of

28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)

Inferred To

ptcd3 [mitochondrial inner membrane] (Danio rerio)

PTCD3 [mitochondrial inner membrane] (Bos taurus)

PTCD3 [mitochondrial inner membrane] (Canis familiaris)

PTCD3 [mitochondrial inner membrane] (Drosophila melanogaster)

PTCD3 [mitochondrial inner membrane] (Sus scrofa)

let-630 [mitochondrial inner membrane] (Caenorhabditis elegans)

Ghost homologue of PTCD3 [mitochondrial inner membrane] (Gallus gallus)

Ptcd3 [mitochondrial inner membrane] (Mus musculus)

Ptcd3 [mitochondrial inner membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_060422.4

OpenTargets

ENSG00000132300

GeneCards

Q96EY7

HPA

ENSG00000132300-PTCD3

Ensembl

ENSG00000132300, ENSP00000254630, ENST00000254630

PRO

Q96EY7

Pharos - Targets

Q96EY7

PDB

8OIS, 7A5K, 7PO2, 7PO3, 8CSP, 6ZSE, 8CSQ, 7A5I, 6ZSD, 8ANY, 6ZM5, 7P2E, 7PO0, 7PNY, 6VLZ, 7PO1, 7PNZ, 8OIR, 6ZSG, 7L08, 8CSU, 6NU3, 6NU2, 6ZS9, 6VMI, 6ZM6, 7OG4, 7PNX, 7A5G, 7QI4, 6ZSC, 8CSR, 3J9M, 6RW5, 6ZSB, 8CSS, 7A5F, 7QI5, 6RW4, 7QI6, 6ZSA, 8CST

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P67809 YBX1	5	p-S32,S36-YBX1 [nucleoplasm] (R-HSA-9733227) p-S32,S36-YBX1 [cytosol] (R-HSA-9736837) YBX1 [cytosol] (R-HSA-9736840) YBX1 [nucleoplasm] (R-HSA-72041) YBX1 [extracellular region] (R-HSA-9017791)	0.744	4
UniProt:P62753 RPS6	4	RPS6 [nucleoplasm] (R-HSA-6790606) 3OHR147-RPS6 [cytosol] (R-HSA-9629876) p-5S-RPS6 [cytosol] (R-HSA-165727) RPS6 [cytosol] (R-HSA-72381)	0.569	4
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:P03372 ESR1	10	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) p-S167-ESR1 [cytosol] (R-HSA-9841254) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.527	3
UniProt:Q9H9Z2 LIN28A	1	LIN28A [cytosol] (R-HSA-500391)	0.527	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	10
UniProt:Q16629 SRSF7	1	SRSF7 [nucleoplasm] (R-HSA-72029)	0.483	2