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GADD45GIP1 [mitochondrial matrix]
Stable Identifier
R-HSA-5368253
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
Growth arrest and DNA damage-inducible proteins-interacting protein 1, G45IP_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Mitochondrial translation (Homo sapiens)
Mitochondrial translation elongation (Homo sapiens)
55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Homo sapiens)
55S ribosome:mRNA:tRNA:peptidyl-tRNA at A-site [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
GADD45GIP1 [mitochondrial matrix] (Homo sapiens)
55S ribosome:mRNA:tRNA:peptidyl-tRNA:GFM1:GTP [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
GADD45GIP1 [mitochondrial matrix] (Homo sapiens)
Peptide transfer from P-site to A-site (peptide bond formation) (Homo sapiens)
55S ribosome:mRNA:fMet-tRNA:aminoacyl-tRNA [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
GADD45GIP1 [mitochondrial matrix] (Homo sapiens)
55S ribosome:mRNA:tRNA:peptidyl-tRNA at A-site [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
GADD45GIP1 [mitochondrial matrix] (Homo sapiens)
TUFM hydrolyzes GTP and TUFM:GDP dissociates from 55S ribosome (Homo sapiens)
55S ribosome:mRNA:fMet-tRNA:aminoacyl-tRNA [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
GADD45GIP1 [mitochondrial matrix] (Homo sapiens)
55S ribosome:mRNA:fMet-tRNA:aminoacyl-tRNA:TUFM:GTP [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:fMet-tRNA [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
GADD45GIP1 [mitochondrial matrix] (Homo sapiens)
TUFM:GTP:aminoacyl-tRNA binds 55S ribosome:mRNA:fMet-tRNA (Homo sapiens)
55S ribosome:mRNA:fMet-tRNA [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
GADD45GIP1 [mitochondrial matrix] (Homo sapiens)
55S ribosome:mRNA:fMet-tRNA:aminoacyl-tRNA:TUFM:GTP [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:fMet-tRNA [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
GADD45GIP1 [mitochondrial matrix] (Homo sapiens)
Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA) (Homo sapiens)
55S ribosome:mRNA:peptidyl-tRNA at P-site [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
GADD45GIP1 [mitochondrial matrix] (Homo sapiens)
55S ribosome:mRNA:tRNA:peptidyl-tRNA:GFM1:GTP [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
GADD45GIP1 [mitochondrial matrix] (Homo sapiens)
Mitochondrial translation initiation (Homo sapiens)
39S subunit binds 28S subunit:mRNA:fMet-tRNA (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
GADD45GIP1 [mitochondrial matrix] (Homo sapiens)
55S ribosome:mRNA:fMet-tRNA [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
GADD45GIP1 [mitochondrial matrix] (Homo sapiens)
Mitochondrial translation termination (Homo sapiens)
55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Homo sapiens)
55S ribosome:mRNA:peptidyl-tRNA:MTRF1L:GTP [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
GADD45GIP1 [mitochondrial matrix] (Homo sapiens)
55S ribosome:mRNA:tRNA [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
GADD45GIP1 [mitochondrial matrix] (Homo sapiens)
GFM2:GTP binds 55S ribosome:mRNA:tRNA:MRRF releasing mRNA and tRNA (Homo sapiens)
55S ribosome:MRRF:GFM2:GTP [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
GADD45GIP1 [mitochondrial matrix] (Homo sapiens)
55S ribosome:mRNA:tRNA:MRRF [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
GADD45GIP1 [mitochondrial matrix] (Homo sapiens)
Hydrolysis of GTP and dissociation of 28S and 39S subunits (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
GADD45GIP1 [mitochondrial matrix] (Homo sapiens)
55S ribosome:MRRF:GFM2:GTP [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
GADD45GIP1 [mitochondrial matrix] (Homo sapiens)
MRRF binds 55S ribosome:mRNA:tRNA (Homo sapiens)
55S ribosome:mRNA:tRNA [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
GADD45GIP1 [mitochondrial matrix] (Homo sapiens)
55S ribosome:mRNA:tRNA:MRRF [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
GADD45GIP1 [mitochondrial matrix] (Homo sapiens)
MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Homo sapiens)
55S ribosome:mRNA:peptidyl-tRNA at P-site [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
GADD45GIP1 [mitochondrial matrix] (Homo sapiens)
55S ribosome:mRNA:peptidyl-tRNA:MTRF1L:GTP [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
GADD45GIP1 [mitochondrial matrix] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8TAE8 GADD45GIP1
Gene Names
GADD45GIP1, MRPL59, PLINP1, PRG6
Chain
chain:1-222
Reference Genes
BioGPS Gene:90480 GADD45GIP1
COSMIC (genes):GADD45GIP1 GADD45GIP1
CTD Gene:90480 GADD45GIP1
dbSNP Gene:90480 GADD45GIP1
ENSEMBL:ENSG00000179271 GADD45GIP1
ENSEMBL_homo_sapiens_GENE:ENSG00000179271.3 GADD45GIP1
HGNC:29996 GADD45GIP1
KEGG Gene (Homo sapiens):90480 GADD45GIP1
Monarch:90480 GADD45GIP1
NCBI Gene:90480 GADD45GIP1
OMIM:605162 GADD45GIP1
UCSC:Q8TAE8 GADD45GIP1
Reference Transcript
RefSeq:NM_052850.3 GADD45GIP1
Other Identifiers
11719082_a_at
16869387
212891_PM_s_at
212891_s_at
3851912
3851913
3851914
3851915
3851916
3851917
3851918
3851919
3851920
8034605
90480
A_23_P39019
A_33_P3273148
GO:0005515
GO:0005634
GO:0005654
GO:0005739
GO:0005743
GO:0005759
GO:0005762
GO:0005840
GO:0007049
GO:0032543
GO:0043226
GO:0140053
GO:1990904
Hs.83135.1.A1_3p_a_at
ILMN_1751530
PH_hs_0027173
TC19001216.hg
Participates
as a component of
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
Inferred To
CRIF [mitochondrial matrix]
(Drosophila melanogaster)
Ghost homologue of GADD45GIP1 [mitochondrial matrix]
(Danio rerio)
Ghost homologue of GADD45GIP1 [mitochondrial matrix]
(Gallus gallus)
GADD45GIP1 [mitochondrial matrix]
(Bos taurus)
GADD45GIP1 [mitochondrial matrix]
(Caenorhabditis elegans)
GADD45GIP1 [mitochondrial matrix]
(Canis familiaris)
GADD45GIP1 [mitochondrial matrix]
(Sus scrofa)
Gadd45gip1 [mitochondrial matrix]
(Mus musculus)
Gadd45gip1 [mitochondrial matrix]
(Rattus norvegicus)
Cross References
RefSeq
NP_443082.2
OpenTargets
ENSG00000179271
GeneCards
Q8TAE8
HPA
ENSG00000179271-GADD45GIP1
Ensembl
ENST00000316939
,
ENSP00000323065
,
ENSG00000179271
PRO
Q8TAE8
Pharos - Targets
Q8TAE8
PDB
8OIT
,
7A5J
,
7OF5
,
7L20
,
7OF0
,
7ODR
,
7OIA
,
5OOL
,
5OOM
,
7OF2
,
7OI6
,
7OIC
,
7A5F
,
7ODS
,
7PO4
,
7QH7
,
6ZSA
,
7O9M
,
7ODT
,
7A5G
,
6ZSE
,
7OF7
,
6NU3
,
6ZM5
,
6VMI
,
7OI9
,
7OF4
,
6ZSB
,
7QH6
,
6ZM6
,
7O9K
,
7OG4
,
7PD3
,
7OIB
,
6ZSC
,
7L08
,
7A5K
,
6I9R
,
3J7Y
,
8OIR
,
3J9M
,
6ZS9
,
7OF6
,
6ZSD
,
7QI5
,
7OIE
,
7OI7
,
6VLZ
,
7OF3
,
7OID
,
6NU2
,
7QI6
,
7QI4
,
7A5I
,
7OI8
,
6ZSG
,
7A5H
Interactors (14)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P40763 STAT3
12
Unfolded STAT3 [cytosol]
(R-HSA-6813811)
p-STAT3 [nucleoplasm]
(R-HSA-8983188)
p-STAT3 [cytosol]
(R-HSA-8982823)
AcK685- p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701435)
p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701429)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-9027589)
p-S727-STAT3 [cytosol]
(R-HSA-198705)
p-Y705,S727-STAT3 [cytosol]
(R-HSA-539048)
p-Y705-STAT3 [cytosol]
(R-HSA-8983130)
STAT3 [cytosol]
(R-HSA-539044)
p-Y705-STAT3 [cytosol]
(R-HSA-914048)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-1112554)
0.635
4
UniProt:P24522 GADD45A
1
GADD45A [nucleoplasm]
(R-HSA-3215139)
0.593
3
UniProt:Q9NRD5 PICK1
2
PICK1 [plasma membrane]
(R-HSA-416989)
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
0.556
3
UniProt:Q13077 TRAF1
3
TRAF1 [cytosol]
(R-HSA-5634163)
TRAF1(1-163) [cytosol]
(R-HSA-5634199)
TRAF1(164-416) [cytosol]
(R-HSA-5634204)
0.556
3
UniProt:P55040 GEM
1
GEM [plasma membrane]
(R-HSA-9769962)
0.556
3
UniProt:P14373 TRIM27
2
TRIM27 [nucleoplasm]
(R-HSA-2997690)
TRIM27 [cytosol]
(R-HSA-8851002)
0.556
3
UniProt:Q08379 GOLGA2
3
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.556
3
UniProt:O00308 WWP2
1
WWP2 [cytosol]
(R-HSA-6807279)
0.556
3
UniProt:O95995 GAS8
1
GAS8 [cytosol]
(R-HSA-5633057)
0.556
3
UniProt:Q9UGI0 ZRANB1
1
ZRANB1 [cytosol]
(R-HSA-6781939)
0.556
3
UniProt:P24863 CCNC
1
CCNC [nucleoplasm]
(R-HSA-212418)
0.556
3
UniProt:Q9UBB9 TFIP11
1
TFIP11 [nucleoplasm]
(R-HSA-8869310)
0.556
3
UniProt:Q96JC9 EAF1
1
EAF1 [nucleoplasm]
(R-HSA-8932787)
0.556
3
UniProt:P42227 Stat3
13
phospho-Stat3 [nucleoplasm]
(R-MMU-1112554)
phospho-Stat3 [cytosol]
(R-MMU-914048)
Stat3 [cytosol]
(R-MMU-539044)
Stat3 [cytosol]
(R-MMU-914084)
p-Y705-Stat3 [cytosol]
(R-MMU-914034)
p(Y705)-Stat3 [nucleoplasm]
(R-MMU-2730582)
phospho-Stat3 [cytosol]
(R-MMU-8983130)
phospho-Stat3 [cytosol]
(R-MMU-539048)
phospho-Stat3 [nucleoplasm]
(R-MMU-9027589)
phospho-Stat3 [nucleoplasm]
(R-MMU-9701429)
phospho-Stat3 [nucleoplasm]
(R-MMU-9701435)
phospho-Stat3 [cytosol]
(R-MMU-8982823)
phospho-Stat3 [nucleoplasm]
(R-MMU-8983188)
0.463
3
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