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MRPS22 [mitochondrial inner membrane]
Stable Identifier
R-HSA-5368259
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial inner membrane
Synonyms
28S ribosomal protein S22, mitochondrial, RT22_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Mitochondrial translation (Homo sapiens)
Mitochondrial translation elongation (Homo sapiens)
55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Homo sapiens)
55S ribosome:mRNA:tRNA:peptidyl-tRNA at A-site [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS22 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:tRNA:peptidyl-tRNA:GFM1:GTP [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS22 [mitochondrial inner membrane] (Homo sapiens)
Peptide transfer from P-site to A-site (peptide bond formation) (Homo sapiens)
55S ribosome:mRNA:fMet-tRNA:aminoacyl-tRNA [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS22 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:tRNA:peptidyl-tRNA at A-site [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS22 [mitochondrial inner membrane] (Homo sapiens)
TUFM hydrolyzes GTP and TUFM:GDP dissociates from 55S ribosome (Homo sapiens)
55S ribosome:mRNA:fMet-tRNA:aminoacyl-tRNA [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS22 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:fMet-tRNA:aminoacyl-tRNA:TUFM:GTP [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:fMet-tRNA [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS22 [mitochondrial inner membrane] (Homo sapiens)
TUFM:GTP:aminoacyl-tRNA binds 55S ribosome:mRNA:fMet-tRNA (Homo sapiens)
55S ribosome:mRNA:fMet-tRNA [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS22 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:fMet-tRNA:aminoacyl-tRNA:TUFM:GTP [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:fMet-tRNA [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS22 [mitochondrial inner membrane] (Homo sapiens)
Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA) (Homo sapiens)
55S ribosome:mRNA:peptidyl-tRNA at P-site [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS22 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:tRNA:peptidyl-tRNA:GFM1:GTP [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS22 [mitochondrial inner membrane] (Homo sapiens)
Mitochondrial translation initiation (Homo sapiens)
28S subunit:MTIF3 binds MTIF2:GTP, mRNA, and formylMet-tRNA (Homo sapiens)
28S ribosomal subunit:MTIF3 [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS22 [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit:MTIF3:MTIF2:GTP:mRNA:fMet-tRNA [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS22 [mitochondrial inner membrane] (Homo sapiens)
39S subunit binds 28S subunit:mRNA:fMet-tRNA (Homo sapiens)
28S ribosomal subunit:MTIF3:MTIF2:GTP:mRNA:fMet-tRNA [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS22 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:fMet-tRNA [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS22 [mitochondrial inner membrane] (Homo sapiens)
MTIF3 binds 28S ribosomal subunit (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS22 [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit:MTIF3 [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS22 [mitochondrial inner membrane] (Homo sapiens)
Mitochondrial translation termination (Homo sapiens)
55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Homo sapiens)
55S ribosome:mRNA:peptidyl-tRNA:MTRF1L:GTP [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS22 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:tRNA [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS22 [mitochondrial inner membrane] (Homo sapiens)
GFM2:GTP binds 55S ribosome:mRNA:tRNA:MRRF releasing mRNA and tRNA (Homo sapiens)
55S ribosome:MRRF:GFM2:GTP [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS22 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:tRNA:MRRF [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS22 [mitochondrial inner membrane] (Homo sapiens)
Hydrolysis of GTP and dissociation of 28S and 39S subunits (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS22 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:MRRF:GFM2:GTP [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS22 [mitochondrial inner membrane] (Homo sapiens)
MRRF binds 55S ribosome:mRNA:tRNA (Homo sapiens)
55S ribosome:mRNA:tRNA [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS22 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:tRNA:MRRF [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS22 [mitochondrial inner membrane] (Homo sapiens)
MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Homo sapiens)
55S ribosome:mRNA:peptidyl-tRNA at P-site [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS22 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:peptidyl-tRNA:MTRF1L:GTP [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS22 [mitochondrial inner membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P82650 MRPS22
Gene Names
MRPS22, C3orf5, RPMS22, GK002
Chain
chain:1-360
Reference Genes
BioGPS Gene:56945 MRPS22
COSMIC (genes):MRPS22 MRPS22
CTD Gene:56945 MRPS22
dbSNP Gene:56945 MRPS22
ENSEMBL:ENSG00000175110 MRPS22
HGNC:14508 MRPS22
KEGG:hsa:56945 MRPS22
Monarch:56945 MRPS22
NCBI Gene:56945 MRPS22
OMIM:605810 MRPS22
UCSC:P82650 MRPS22
Reference Transcript
RefSeq:NM_020191.2 MRPS22
Other Identifiers
11724669_a_at
11748325_x_at
16946228
219220_PM_x_at
219220_x_at
223448_PM_x_at
223448_x_at
226257_PM_x_at
226257_x_at
228059_PM_x_at
228059_x_at
231314_PM_at
231314_at
2644823
2644824
2644825
2644826
2644828
2644829
2644830
2644849
2644850
2644851
2644852
2644853
2644854
2644855
2644856
2644857
2644858
2644859
2644860
2644861
2644862
2644863
2644864
2644865
2644866
2644867
2644868
2644880
2644889
2644891
2644893
2644895
49141_at
52486_at
56945
8083011
A_14_P129925
A_23_P72138
GE489617
GE56412
GO:0003735
GO:0005198
GO:0005515
GO:0005739
GO:0005743
GO:0005761
GO:0005763
GO:0005840
GO:0008150
GO:0032543
GO:0043226
GO:1990904
HMNXSV003055305
Hs.22226.0.A1_3p_at
ILMN_1655377
PH_hs_0026793
TC03000748.hg
g9910243_3p_a_at
Participates
as a component of
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
Inferred To
MRPS22 [mitochondrial inner membrane]
(Bos taurus)
MRPS22 [mitochondrial inner membrane]
(Canis familiaris)
MRPS22 [mitochondrial inner membrane]
(Gallus gallus)
MRPS22 [mitochondrial inner membrane]
(Sus scrofa)
mrps22 [mitochondrial inner membrane]
(Danio rerio)
mRpS22 [mitochondrial inner membrane]
(Drosophila melanogaster)
mrps-22 [mitochondrial inner membrane]
(Caenorhabditis elegans)
Mrps22 [mitochondrial inner membrane]
(Mus musculus)
Mrps22 [mitochondrial inner membrane]
(Rattus norvegicus)
Cross References
OpenTargets
ENSG00000175110
ENSEMBL
ENSP00000420482
,
ENST00000680020
,
ENSP00000510396
,
ENSP00000418008
,
ENST00000495075
,
ENSP00000505414
,
ENST00000498505
,
ENST00000688697
HPA
ENSG00000175110-MRPS22
PRO
P82650
Pharos - Targets
P82650
Orphanet
MRPS22
GlyGen
P82650
PDB
8CSR
,
8CSP
,
7A5I
,
7A5G
,
6NU3
,
7A5F
,
6RW5
,
8ANY
,
6RW4
,
6NU2
,
7QI4
,
7PNZ
,
6VLZ
,
7PO3
,
8CSU
,
7L08
,
7P2E
,
7OG4
,
7QI6
,
6ZSE
,
7PNY
,
8CST
,
7QI5
,
7PO2
,
6VMI
,
6ZM5
,
6ZM6
,
6ZSD
,
6ZSC
,
7PO1
,
7PNX
,
7PO0
,
6ZSB
,
8OIS
,
6ZSA
,
6ZSG
,
8CSQ
,
6ZS9
,
8OIR
,
3J9M
,
8CSS
,
7A5K
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P67809 YBX1
5
p-S32,S36-YBX1 [nucleoplasm]
(R-HSA-9733227)
p-S32,S36-YBX1 [cytosol]
(R-HSA-9736837)
YBX1 [cytosol]
(R-HSA-9736840)
YBX1 [nucleoplasm]
(R-HSA-72041)
YBX1 [extracellular region]
(R-HSA-9017791)
0.643
3
UniProt:P03372 ESR1
10
ESR1 [cytosol]
(R-HSA-9020968)
ESR1 [nucleoplasm]
(R-HSA-446168)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
0.527
3
UniProt:P48431 SOX2
1
SOX2 [nucleoplasm]
(R-HSA-452271)
0.483
2
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