Reactome | MTIF3 [mitochondrial matrix]

MTIF3 [mitochondrial matrix]

Stable Identifier

R-HSA-5368284

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

Translation initiation factor IF-3, mitochondrial, IF3M_HUMAN

Locations in the PathwayBrowser for interactor UniProt:O75379 VAMP4

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External Reference Information

External Reference

UniProt:Q9H2K0 MTIF3

Gene Names

MTIF3, DC38

Chain

transit peptide:1-31, chain:32-278

Reference Genes

BioGPS Gene:219402 MTIF3

COSMIC (genes):MTIF3 MTIF3

CTD Gene:219402 MTIF3

dbSNP Gene:219402 MTIF3

ENSEMBL:ENSG00000122033 MTIF3

HGNC:29788 MTIF3

KEGG:hsa:219402 MTIF3

Monarch:219402 MTIF3

NCBI Gene:219402 MTIF3

OMIM:619554 MTIF3

UCSC:Q9H2K0 MTIF3

Reference Transcript

Other Identifiers

11757335_s_at

11762669_at

16777634

219402

223356_PM_s_at

223356_s_at

3506938

3506939

3506940

3506941

3506942

3506943

3506944

3506945

3506946

3506947

3506948

3506951

3506952

3506953

3506954

3506956

3506958

3506962

3506963

3506964

3506965

3506966

3506967

44079_at

63860_at

7970704

84866_i_at

A_23_P53788

GO:0003743

GO:0005515

GO:0005739

GO:0006412

GO:0006413

GO:0008135

GO:0032790

GO:0043022

GO:0043024

GO:0043226

GO:0045182

GO:0070124

HMNXSV003050267

Hs.75113.1.A1_3p_a_at

ILMN_1718271

PH_hs_0020688

TC13000510.hg

Participates

as an input of

MTIF3 binds 28S ribosomal subunit (Homo sapiens)

as a component of

as an output of

39S subunit binds 28S subunit:mRNA:fMet-tRNA (Homo sapiens)

Cross References

OpenTargets

ENSG00000122033

ENSEMBL

ENSP00000370512, ENST00000405591, ENSP00000384659, ENST00000381116, ENSP00000370508, ENST00000381120

HPA

ENSG00000122033-MTIF3

PRO

Q9H2K0

Pharos - Targets

Q9H2K0

PDB

6RW5, 6NF8, 7P2E, 6RW4, 6NEQ

Interactors (79)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q07817 BCL2L1	2	BCL2L1 [cytosol] (R-HSA-50771) BCL2L1 [mitochondrial outer membrane] (R-HSA-114236)	0.556	3
UniProt:Q96HP8 T176A			0.556	3
UniProt:Q99675 CGRF1			0.556	3
UniProt:Q96MV8 ZDH15			0.556	3
UniProt:Q14802-3 FXYD3			0.556	3
UniProt:P11836 CD20			0.556	3
UniProt:O75379 VAMP4	4	VAMP4 [transport vesicle] (R-HSA-6811023) VAMP4 [trans-Golgi network membrane] (R-HSA-6811021) VAMP4 [plasma membrane] (R-HSA-8864461) VAMP4 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869133)	0.556	3
UniProt:Q4LDR2 CTXN3			0.556	3
UniProt:P78329 CYP4F2	1	CYP4F2 [endoplasmic reticulum membrane] (R-HSA-211016)	0.556	3
UniProt:Q9Y605 MOFA1			0.556	3
UniProt:Q8WW34-2 TMEM239			0.556	3
UniProt:A2RU14 TM218			0.556	3
UniProt:A0A384ME17 A0A384ME17			0.556	3
UniProt:Q9NS64 RPRM			0.556	3
UniProt:Q8N6R1 SERP2			0.556	3
UniProt:Q8N138 ORMDL3	4	ORMDL3 [secretory granule membrane] (R-HSA-6800882) ORMDL3 [plasma membrane] (R-HSA-6806293) ORMDL3 [specific granule membrane] (R-HSA-6799643) ORMDL3 [endoplasmic reticulum membrane] (R-HSA-8865589)	0.556	3
UniProt:P07204 THBD	1	THBD [plasma membrane] (R-HSA-141030)	0.556	3
UniProt:O14735 CDIPT	1	CDIPT [endoplasmic reticulum membrane] (R-HSA-1498749)	0.556	3
UniProt:A5PKU2 A5PKU2			0.556	3
UniProt:Q5MJ10 SPXN2			0.556	3
UniProt:P05107 ITGB2	4	ITGB2 [plasma membrane] (R-HSA-198010) ITGB2 [ficolin-1-rich granule membrane] (R-HSA-6803310) ITGB2 [specific granule membrane] (R-HSA-6803284) ITGB2 [tertiary granule membrane] (R-HSA-6803342)	0.556	3
UniProt:Q9UBD0 HSFX1			0.556	3
UniProt:Q96DZ9-2 CMTM5			0.556	3
UniProt:O60749 SNX2	2	SNX2 [Golgi membrane] (R-HSA-434333) SNX2 [cytoplasmic vesicle membrane] (R-HSA-434216)	0.556	3
UniProt:Q08722-3 CD47			0.556	3
UniProt:Q6PL45-2 BRICD5			0.556	3
UniProt:Q96EC8 YIPF6	2	YIPF6 [Golgi membrane] (R-HSA-434346) YIPF6 [cytoplasmic vesicle membrane] (R-HSA-434199)	0.556	3
UniProt:Q6UW88-2 Q6UW882			0.556	3
UniProt:Q9BXN2-6 CLEC7A			0.556	3
UniProt:Q8TAF8 LHFPL5	1	LHFPL5 [plasma membrane] (R-HSA-9658860)	0.556	3
UniProt:A2A2V5 SRTM1			0.556	3
UniProt:Q9NWH2 TM242			0.556	3
UniProt:P02808 STAT			0.556	3
UniProt:O00767 SCD	1	SCD [endoplasmic reticulum membrane] (R-HSA-400117)	0.556	3
UniProt:O14880 MGST3	1	MGST3 [endoplasmic reticulum membrane] (R-HSA-176053)	0.556	3
UniProt:O43752 STX6	2	STX6 [trans-Golgi network membrane] (R-HSA-6811007) STX6 [Golgi membrane] (R-HSA-6811004)	0.556	3
UniProt:Q8IUQ4 SIAH1	1	SIAH1 [cytosol] (R-HSA-374563)	0.556	3
UniProt:Q9BVK8 TM147			0.556	3
UniProt:Q9UGM5 FETUB			0.556	3
UniProt:Q9Y6X1 SERP1	2	SERP1 [endoplasmic reticulum membrane] (R-HSA-381045) SERP1 [cytosol] (R-HSA-5250574)	0.556	3
UniProt:P17152 TMEM11	1	TMEM11 [mitochondrial inner membrane] (R-HSA-8949578)	0.556	3
UniProt:P01130 LDLR	4	LDLR [plasma membrane] (R-HSA-171053) LDLR [clathrin-coated endocytic vesicle membrane] (R-HSA-171105) LDLR [endosome membrane] (R-HSA-171127) LDLR [endolysosome membrane] (R-HSA-6784818)	0.556	3
UniProt:Q8NI60 COQ8A	1	COQ8A [mitochondrial inner membrane] (R-HSA-9856284)	0.556	3
UniProt:P0DN84 DWORF			0.556	3
UniProt:Q5BJH2-2 TMEM128			0.556	3
UniProt:Q86V35 CABP7			0.556	3
UniProt:Q9C0I4 THSD7B	3	THSD7B [endoplasmic reticulum lumen] (R-HSA-5173101) glc-fuc-THSD7B [endoplasmic reticulum lumen] (R-HSA-5172957) O-fuc-THSD7B [endoplasmic reticulum lumen] (R-HSA-5173124)	0.556	3
UniProt:Q07325 CXCL9	1	CXCL9 [extracellular region] (R-HSA-373856)	0.556	3
IntAct:EBI-23343277 CCSB ORF ID			0.556	3
UniProt:Q86UF1 TSPAN33	2	TSPAN33 [plasma membrane] (R-HSA-9010024) TSPAN33 [endoplasmic reticulum lumen] (R-HSA-9010054)	0.556	3
UniProt:O95674 CDS2	1	CDS2 [mitochondrial inner membrane] (R-HSA-1498755)	0.556	3
UniProt:Q9ULP0-2 NDRG4			0.556	3
UniProt:Q6PL24 TMED8			0.556	3
UniProt:Q9Y6D0 SELK			0.556	3
UniProt:O95393 BMP10	2	BMP10(22-424) [extracellular region] (R-HSA-2396409) BMP10 [extracellular region] (R-HSA-8858374)	0.556	3
UniProt:Q8N0U8 VKORC1L1	1	VKORC1L1 [endoplasmic reticulum membrane] (R-HSA-2980944)	0.556	3
UniProt:Q5BJF2 SGMR2			0.556	3
UniProt:Q9BQA9 CYBC1			0.556	3
UniProt:Q9BVC6 TM109			0.556	3
UniProt:P29400-2 COL4A5			0.556	3
UniProt:Q13277 STX3	1	STX3 [plasma membrane] (R-HSA-449131)	0.556	3
UniProt:Q53HI1 UNC50			0.556	3
UniProt:Q9BU79 TM243			0.556	3
UniProt:Q8TBM7 TM254			0.556	3
UniProt:O95125 ZNF202	1	ZNF202 [nucleoplasm] (R-HSA-975010)	0.556	3
UniProt:P05090 APOD	1	APOD [extracellular region] (R-HSA-5216199)	0.556	3
IntAct:EBI-23194662 CCSB ORF ID			0.556	3
UniProt:Q8NHS1 CLDN2			0.556	3
UniProt:Q86VI4 LAP4B			0.556	3
UniProt:P60201-2 PLP1			0.556	3
UniProt:Q9BUP3-3 HTATIP2			0.556	3
UniProt:A0A087WZY1 A0A087WZY1			0.556	3
UniProt:Q96DR4 STARD4	1	STARD4 [cytosol] (R-HSA-196083)	0.556	3
UniProt:Q69YG0 TMM42			0.556	3
UniProt:Q9NP55 BPIFA1	1	BPIFA1 [extracellular region] (R-HSA-6809280)	0.556	3
UniProt:Q9UHE5 NAT8	1	NAT8 [endoplasmic reticulum membrane] (R-HSA-5692986)	0.556	3
UniProt:Q8N5M9 JAGN1			0.556	3
UniProt:O43561-2 LAT	2	p-5Y-LAT-2 [plasma membrane] (R-HSA-2396597) LAT-2 [plasma membrane] (R-HSA-2396548)	0.556	3
UniProt:P26678 PLN	2	p-S16-PLN [sarcoplasmic reticulum membrane] (R-HSA-5578813) PLN [sarcoplasmic reticulum membrane] (R-HSA-5490319)	0.556	3

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