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LIG1 [nucleoplasm]
Stable Identifier
R-HSA-53787
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
DNA ligase I , Polydeoxyribonucleotide synthase (ATP)
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
S Phase (Homo sapiens)
Synthesis of DNA (Homo sapiens)
DNA strand elongation (Homo sapiens)
Lagging Strand Synthesis (Homo sapiens)
Processive synthesis on the lagging strand (Homo sapiens)
Joining of adjacent Okazaki fragments (Homo sapiens)
LIG1 [nucleoplasm] (Homo sapiens)
Chromosome Maintenance (Homo sapiens)
Telomere Maintenance (Homo sapiens)
Extension of Telomeres (Homo sapiens)
Telomere C-strand (Lagging Strand) Synthesis (Homo sapiens)
Processive synthesis on the C-strand of the telomere (Homo sapiens)
Joining of adjacent Okazaki fragments of the C-strand (Homo sapiens)
LIG1 [nucleoplasm] (Homo sapiens)
DNA Repair (Homo sapiens)
Base Excision Repair (Homo sapiens)
Resolution of Abasic Sites (AP sites) (Homo sapiens)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Homo sapiens)
PCNA-Dependent Long Patch Base Excision Repair (Homo sapiens)
LIG1 binds APEX1 and PCNA at SSB (Homo sapiens)
LIG1 [nucleoplasm] (Homo sapiens)
LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:SSB:(3'poly-dNMP)-dsDNA [nucleoplasm] (Homo sapiens)
LIG1 [nucleoplasm] (Homo sapiens)
LIG1 bound to APEX1 and PCNA ligates SSB (Homo sapiens)
LIG1 [nucleoplasm] (Homo sapiens)
LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:SSB:(3'poly-dNMP)-dsDNA [nucleoplasm] (Homo sapiens)
LIG1 [nucleoplasm] (Homo sapiens)
LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:dsDNA [nucleoplasm] (Homo sapiens)
LIG1 [nucleoplasm] (Homo sapiens)
LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA (Homo sapiens)
LIG1 [nucleoplasm] (Homo sapiens)
LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:dsDNA [nucleoplasm] (Homo sapiens)
LIG1 [nucleoplasm] (Homo sapiens)
POLB-Dependent Long Patch Base Excision Repair (Homo sapiens)
LIG1 and POLB dissociate from repaired dsDNA (Homo sapiens)
LIG1 [nucleoplasm] (Homo sapiens)
LIG1:POLB:dsDNA [nucleoplasm] (Homo sapiens)
LIG1 [nucleoplasm] (Homo sapiens)
LIG1 binds POLB at long-patch BER site (Homo sapiens)
LIG1 [nucleoplasm] (Homo sapiens)
LIG1:POLB:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Homo sapiens)
LIG1 [nucleoplasm] (Homo sapiens)
LIG1 bound to POLB ligates SSB (Homo sapiens)
LIG1 [nucleoplasm] (Homo sapiens)
LIG1:POLB:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Homo sapiens)
LIG1 [nucleoplasm] (Homo sapiens)
LIG1:POLB:dsDNA [nucleoplasm] (Homo sapiens)
LIG1 [nucleoplasm] (Homo sapiens)
Mismatch Repair (Homo sapiens)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (Homo sapiens)
DNA ligase I ligates single stranded nick in double stranded DNA (Homo sapiens)
LIG1 [nucleoplasm] (Homo sapiens)
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (Homo sapiens)
DNA ligase I ligates single stranded nick in double stranded DNA (Homo sapiens)
LIG1 [nucleoplasm] (Homo sapiens)
Nucleotide Excision Repair (Homo sapiens)
Global Genome Nucleotide Excision Repair (GG-NER) (Homo sapiens)
Gap-filling DNA repair synthesis and ligation in GG-NER (Homo sapiens)
Ligation of newly synthesized repair patch to incised DNA in GG-NER (Homo sapiens)
LIG1,LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
LIG1 [nucleoplasm] (Homo sapiens)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Homo sapiens)
Gap-filling DNA repair synthesis and ligation in TC-NER (Homo sapiens)
Ligation of newly synthesized repair patch to incised DNA in TC-NER (Homo sapiens)
LIG1,LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
LIG1 [nucleoplasm] (Homo sapiens)
DNA Replication (Homo sapiens)
Synthesis of DNA (Homo sapiens)
DNA strand elongation (Homo sapiens)
Lagging Strand Synthesis (Homo sapiens)
Processive synthesis on the lagging strand (Homo sapiens)
Joining of adjacent Okazaki fragments (Homo sapiens)
LIG1 [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
MITF-M-regulated melanocyte development (Homo sapiens)
MITF-M-dependent gene expression (Homo sapiens)
Regulation of MITF-M-dependent genes involved in DNA damage repair and senescence (Homo sapiens)
MITF-M-dependent LIG1 expression (Homo sapiens)
LIG1 [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HIV Infection (Homo sapiens)
HIV Life Cycle (Homo sapiens)
Early Phase of HIV Life Cycle (Homo sapiens)
Removal of plus-strand flap and gap closure complete synthesis of linear duplex viral DNA (Homo sapiens)
LIG1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P18858 LIG1
Gene Names
LIG1
Chain
chain:1-919
Reference Genes
BioGPS Gene:3978 LIG1
COSMIC (genes):LIG1 LIG1
CTD Gene:3978 LIG1
dbSNP Gene:3978 LIG1
ENSEMBL:ENSG00000105486 LIG1
ENSEMBL_homo_sapiens_GENE:ENSG00000105486.15 LIG1
HGNC:6598 LIG1
KEGG Gene (Homo sapiens):3978 LIG1
Monarch:3978 LIG1
NCBI Gene:3978 LIG1
OMIM:126391 LIG1
UCSC:P18858 LIG1
Reference Transcript
RefSeq:NM_000234.2 LIG1
RefSeq:NM_001289064.1 LIG1
RefSeq:NM_001320971.1 LIG1
RefSeq:NM_001289063.1 LIG1
RefSeq:NM_001320970.1 LIG1
Other Identifiers
11724492_a_at
11744398_a_at
11745979_a_at
11747796_a_at
11749423_a_at
11752816_a_at
1376_at
16873848
202726_PM_at
202726_at
3866899
3866900
3866901
3866902
3866903
3866905
3866908
3866911
3866912
3866913
3866915
3866916
3866919
3866922
3866923
3866925
3866926
3866927
3866928
3866929
3866931
3866934
3866936
3866937
3866938
3866939
3866940
3866941
3866942
3866944
3866945
3866946
3866948
3866950
3866951
3866952
3866953
3866954
3978
74835_r_at
8037991
A_23_P39116
GE57950
GO:0000166
GO:0000278
GO:0003677
GO:0003824
GO:0003909
GO:0003910
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005739
GO:0006260
GO:0006266
GO:0006273
GO:0006281
GO:0006284
GO:0006287
GO:0006298
GO:0006310
GO:0006974
GO:0007049
GO:0009653
GO:0016874
GO:0043226
GO:0043231
GO:0046872
GO:0048856
GO:0051301
GO:0071897
GO:0140097
GO:1903461
HMNXSV003002603
HMNXSV003004339
ILMN_1706779
M36067_at
PH_hs_0000241
TC19001676.hg
TC19002533.hg
g4557718_3p_at
Participates
as an output of
LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA (Homo sapiens)
LIG1 and POLB dissociate from repaired dsDNA (Homo sapiens)
MITF-M-dependent LIG1 expression (Homo sapiens)
as a component of
LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:dsDNA [nucleoplasm] (Homo sapiens)
LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:SSB:(3'poly-dNMP)-dsDNA [nucleoplasm] (Homo sapiens)
LIG1:POLB:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Homo sapiens)
LIG1:POLB:dsDNA [nucleoplasm] (Homo sapiens)
as an input of
LIG1 binds APEX1 and PCNA at SSB (Homo sapiens)
LIG1 binds POLB at long-patch BER site (Homo sapiens)
as a member of
LIG1,LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
This entity regulates
Positively
Removal of plus-strand flap and gap closure complete synthesis of linear duplex viral DNA
(Homo sapiens)
Inferred To
DNAlig1 [nucleoplasm]
(Drosophila melanogaster)
LIG1 [nucleoplasm]
(Bos taurus)
LIG1 [nucleoplasm]
(Caenorhabditis elegans)
LIG1 [nucleoplasm]
(Canis familiaris)
LIG1 [nucleoplasm]
(Dictyostelium discoideum)
LIG1 [nucleoplasm]
(Gallus gallus)
LIG1 [nucleoplasm]
(Mus musculus)
LIG1 [nucleoplasm]
(Plasmodium falciparum)
LIG1 [nucleoplasm]
(Rattus norvegicus)
LIG1 [nucleoplasm]
(Saccharomyces cerevisiae)
LIG1 [nucleoplasm]
(Schizosaccharomyces pombe)
LIG1 [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_001275992.1
,
NP_000225.1
,
NP_001275993.1
,
NP_001307900.1
,
NP_001307899.1
OpenTargets
ENSG00000105486
GeneCards
P18858
ZINC - Substances
DNLI1_HUMAN
HPA
ENSG00000105486-LIG1
Ensembl
ENST00000427526
,
ENSP00000514664
,
ENSG00000105486
,
ENSP00000263274
,
ENSP00000442841
,
ENST00000263274
,
ENSP00000471836
,
ENST00000601091
,
ENST00000699868
ZINC target
P18858
PRO
P18858
Pharos - Targets
P18858
ZINC - Predictions - Purchasable
DNLI1_HUMAN
HMDB Protein
HMDBP00660
PDB
6P0D
,
6Q1V
,
7SUM
,
7KR4
,
5YY9
,
6P09
,
6P0C
,
7KR3
,
7SX5
,
6P0B
,
7L35
,
1X9N
,
7SXE
,
7QO1
,
7L34
,
6P0A
,
8B8T
,
6P0E
,
7QNZ
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