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LIG3 [nucleoplasm]
Stable Identifier
R-HSA-53789
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
DNA ligase III , Polydeoxyribonucleotide synthase (ATP)
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
Base Excision Repair (Homo sapiens)
Resolution of Abasic Sites (AP sites) (Homo sapiens)
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway (Homo sapiens)
LIG3 ligates NEIL1,NEIL2-generated single strand break (Homo sapiens)
LIG3 [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB-dsDNA [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
LIG3 [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:dsDNA [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
LIG3 [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
LIG3 [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
LIG3 [nucleoplasm] (Homo sapiens)
LIG3:XRCC1, POLB, NEIL1,NEIL2 and PNKP dissociate from the BER site (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
LIG3 [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:dsDNA [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
LIG3 [nucleoplasm] (Homo sapiens)
PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Homo sapiens)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
LIG3 [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2:POLB:LIG3:XRCC1:PNKP:SSB-gap-dsDNA [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
LIG3 [nucleoplasm] (Homo sapiens)
POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Homo sapiens)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB-dsDNA [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
LIG3 [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2:POLB:LIG3:XRCC1:PNKP:SSB-gap-dsDNA [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
LIG3 [nucleoplasm] (Homo sapiens)
Resolution of AP sites via the single-nucleotide replacement pathway (Homo sapiens)
Dissociation of LIG3:XRCC1 complex from the BER site (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
LIG3 [nucleoplasm] (Homo sapiens)
LIG3:XRCC1:POLB:dsDNA [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
LIG3 [nucleoplasm] (Homo sapiens)
LIG3-mediated DNA ligation via the single-nucleotide replacement pathway (Homo sapiens)
LIG3 [nucleoplasm] (Homo sapiens)
LIG3:XRCC1:POLB:SSB-dsDNA [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
LIG3 [nucleoplasm] (Homo sapiens)
LIG3:XRCC1:POLB:dsDNA [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
LIG3 [nucleoplasm] (Homo sapiens)
Recruitment of LIG3:XRCC1 complex to the site of repair by POLB (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
LIG3 [nucleoplasm] (Homo sapiens)
LIG3:XRCC1:POLB:SSB-gap-dsDNA [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
LIG3 [nucleoplasm] (Homo sapiens)
Resynthesis of excised residue by POLB (Homo sapiens)
LIG3:XRCC1:POLB:SSB-dsDNA [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
LIG3 [nucleoplasm] (Homo sapiens)
LIG3:XRCC1:POLB:SSB-gap-dsDNA [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
LIG3 [nucleoplasm] (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
Homology Directed Repair (Homo sapiens)
HDR through MMEJ (alt-NHEJ) (Homo sapiens)
LIG3 ligates remaining SSBs in MMEJ (Homo sapiens)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
LIG3 [nucleoplasm] (Homo sapiens)
LIG3 [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
LIG3 [nucleoplasm] (Homo sapiens)
MRN recruits LIG3:XRCC1 to MMEJ sites (Homo sapiens)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
LIG3 [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
LIG3 [nucleoplasm] (Homo sapiens)
Nucleotide Excision Repair (Homo sapiens)
Global Genome Nucleotide Excision Repair (GG-NER) (Homo sapiens)
Gap-filling DNA repair synthesis and ligation in GG-NER (Homo sapiens)
Ligation of newly synthesized repair patch to incised DNA in GG-NER (Homo sapiens)
LIG1,LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
LIG3 [nucleoplasm] (Homo sapiens)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Homo sapiens)
Gap-filling DNA repair synthesis and ligation in TC-NER (Homo sapiens)
Ligation of newly synthesized repair patch to incised DNA in TC-NER (Homo sapiens)
LIG1,LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
LIG3 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P49916 LIG3
Gene Names
LIG3
Chain
transit peptide:1-42, chain:43-1009
Reference Genes
BioGPS Gene:3980 LIG3
COSMIC (genes):LIG3 LIG3
CTD Gene:3980 LIG3
dbSNP Gene:3980 LIG3
ENSEMBL:ENSG00000005156 LIG3
ENSEMBL_homo_sapiens_GENE:ENSG00000005156.12 LIG3
HGNC:6600 LIG3
KEGG Gene (Homo sapiens):3980 LIG3
Monarch:3980 LIG3
NCBI Gene:3980 LIG3
OMIM:600940 LIG3
UCSC:P49916 LIG3
Reference Transcript
RefSeq:XM_017024624.1 LIG3
RefSeq:NM_002311.4 LIG3
RefSeq:NM_013975.3 LIG3
Other Identifiers
11725377_a_at
11735658_a_at
11750294_a_at
11760526_at
11760527_s_at
11763629_s_at
11763630_x_at
1187_at
1188_g_at
1554597_PM_at
1554597_at
1554599_PM_x_at
1554599_x_at
16833263
16833292
204123_PM_at
204123_at
207348_PM_s_at
207348_s_at
229861_PM_at
229861_at
237919_PM_at
237919_at
3718398
3718400
3718402
3718403
3718404
3718405
3718406
3718407
3718408
3718409
3718410
3718411
3718412
3718413
3718414
3718415
3718416
3718417
3718418
3718419
3718420
3718421
3718422
3718423
3718424
3718425
3718426
3718427
3718428
3718429
3718455
3718457
3718459
3718461
3718463
3718465
3718467
3718469
3718471
3980
41099_at
58527_s_at
8006479
A_23_P501134
A_24_P119519
A_32_P204624
GE60093
GE691263
GE81144
GO:0000166
GO:0000724
GO:0003677
GO:0003824
GO:0003909
GO:0003910
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005739
GO:0006260
GO:0006273
GO:0006281
GO:0006287
GO:0006288
GO:0006302
GO:0006310
GO:0006974
GO:0007005
GO:0007049
GO:0008270
GO:0016874
GO:0043226
GO:0043504
GO:0046872
GO:0051052
GO:0051301
GO:0070421
GO:0071897
GO:0090298
GO:0140097
HMNXSV003022969
HMNXSV003029279
HMNXSV003037510
Hs.282952.0.A1_3p_at
Hs.30724.1.S1_3p_at
Hs2.100299.3.A1_3p_s_at
Hs2.30724.2.S1_3p_at
ILMN_1660582
ILMN_1694582
ILMN_2373335
PH_hs_0005604
PH_hs_0031008
TC17000391.hg
TC17000392.hg
X84740_at
g7710125_3p_at
g7710127_3p_a_at
g7710127_3p_x_at
p7315
p7316
Participates
as a component of
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
Inferred To
LIG3 [nucleoplasm]
(Bos taurus)
LIG3 [nucleoplasm]
(Canis familiaris)
LIG3 [nucleoplasm]
(Dictyostelium discoideum)
LIG3 [nucleoplasm]
(Gallus gallus)
LIG3 [nucleoplasm]
(Mus musculus)
LIG3 [nucleoplasm]
(Sus scrofa)
DNAlig3 [nucleoplasm]
(Drosophila melanogaster)
Lig3 [nucleoplasm]
(Rattus norvegicus)
Ghost homologue of LIG3 [nucleoplasm]
(Danio rerio)
lig3 [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
XP_016880113.1
,
NP_002302.2
,
NP_039269.2
OpenTargets
ENSG00000005156
HPA
ENSG00000005156-LIG3
GeneCards
P49916
Ensembl
ENST00000378526
,
ENSG00000005156
,
ENST00000262327
,
ENSP00000262327
,
ENSP00000367787
PRO
P49916
Pharos - Targets
P49916
HMDB Protein
HMDBP00607
PDB
6WH1
,
3PC8
,
1IN1
,
1IMO
,
1UW0
,
3L2P
,
3QVG
,
3PC7
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05412 JUN
4
JUN [nucleoplasm]
(R-HSA-450250)
p-S63,S73-JUN [nucleoplasm]
(R-HSA-450237)
JUN [cytosol]
(R-HSA-168194)
p-S63,S73-JUN [cytosol]
(R-HSA-8868682)
0.462
3
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