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CTSG [plasma membrane]
Stable Identifier
R-HSA-538738
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Cathepsin G, CATG_HUMAN
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Homo sapiens)
Degradation of the extracellular matrix (Homo sapiens)
Fibronectin degradation by CTSG (Homo sapiens)
CTSG [plasma membrane] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Peptide hormone metabolism (Homo sapiens)
Metabolism of Angiotensinogen to Angiotensins (Homo sapiens)
Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Homo sapiens)
Cathepsin G [plasma membrane] (Homo sapiens)
CTSG [plasma membrane] (Homo sapiens)
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) (Homo sapiens)
Cathepsin G proteolyzes IGF:IGFBP3:ALS (Homo sapiens)
Cathepsin G [plasma membrane] (Homo sapiens)
CTSG [plasma membrane] (Homo sapiens)
General
After secretion Cathepsin G is extracellular and associated with the plasma membrane.
Literature References
PubMed ID
Title
Journal
Year
2681419
Elastase and cathepsin G of human monocytes. Quantification of cellular content, release in response to stimuli, and heterogeneity in elastase-mediated proteolytic activity
Campbell, MA
,
Silverman, EK
,
Campbell, EJ
J Immunol
1989
External Reference Information
External Reference
UniProt:P08311 CTSG
Gene Names
CTSG
Chain
signal peptide:1-18, propeptide:19-20, chain:21-244, chain:21-243, propeptide:245-255
Reference Genes
BioGPS Gene:1511 CTSG
COSMIC (genes):CTSG CTSG
CTD Gene:1511 CTSG
dbSNP Gene:1511 CTSG
ENSEMBL:ENSG00000100448 CTSG
ENSEMBL_homo_sapiens_GENE:ENSG00000100448.4 CTSG
HGNC:2532 CTSG
KEGG Gene (Homo sapiens):1511 CTSG
Monarch:1511 CTSG
NCBI Gene:1511 CTSG
OMIM:116830 CTSG
UCSC:P08311 CTSG
Reference Transcript
RefSeq:NM_001911.2 CTSG
Other Identifiers
11723339_at
1511
16791427
205653_PM_at
205653_at
3558348
3558349
3558350
3558352
3558353
3558354
3558357
3558358
37105_at
679_at
7978351
A_23_P140384
GE57841
GO:0002003
GO:0002376
GO:0002548
GO:0003013
GO:0003824
GO:0004252
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005737
GO:0005764
GO:0005773
GO:0005829
GO:0005886
GO:0006468
GO:0006508
GO:0006935
GO:0006955
GO:0007155
GO:0008201
GO:0008233
GO:0008236
GO:0010494
GO:0016020
GO:0016485
GO:0016787
GO:0019221
GO:0019538
GO:0019731
GO:0022617
GO:0023052
GO:0030141
GO:0030168
GO:0030198
GO:0030312
GO:0031012
GO:0031410
GO:0032496
GO:0035578
GO:0035590
GO:0036211
GO:0042060
GO:0042119
GO:0042742
GO:0043226
GO:0043231
GO:0048018
GO:0048870
GO:0050778
GO:0050829
GO:0050830
GO:0050832
GO:0050868
GO:0050886
GO:0051604
GO:0062023
GO:0070062
GO:0070946
GO:0071222
GO:0089720
GO:0098542
GO:0098772
GO:0098786
GO:0140096
GO:1901731
HMNXSV003047913
ILMN_1680424
J04990_at
TC14000980.hg
g4503148_3p_at
Participates
as a member of
Cathepsin G [plasma membrane] (Homo sapiens)
Other forms of this molecule
CTSG [cytosol]
CTSG [azurophil granule lumen]
CTSG [extracellular region]
Inferred To
Ctsg [plasma membrane]
(Mus musculus)
Ctsg [plasma membrane]
(Rattus norvegicus)
CTSG [plasma membrane]
(Canis familiaris)
CTSG [plasma membrane]
(Gallus gallus)
CTSG [plasma membrane]
(Sus scrofa)
LOC505658 [plasma membrane]
(Bos taurus)
ctsg [plasma membrane]
(Xenopus tropicalis)
Homologues of CTSG [plasma membrane]
(Gallus gallus)
Cross References
RefSeq
NP_001902.1
ZINC - World Drugs
CATG_HUMAN
Guide to Pharmacology - Targets
2348
OpenTargets
ENSG00000100448
ZINC - FDA approved
CATG_HUMAN
ZINC - Substances
CATG_HUMAN
ZINC - Biogenic
CATG_HUMAN
ZINC target
P08311
PRO
P08311
PDB
8D7I
,
8G24
,
8D4S
,
1T32
,
8G25
,
1AU8
,
8D4V
,
8D7K
,
1KYN
,
6VTM
,
8G26
,
1CGH
ZINC - Investigational
CATG_HUMAN
IntEnz
3.4.21.20
HPA
ENSG00000100448-CTSG
GeneCards
P08311
Ensembl
ENSP00000216336
,
ENSG00000100448
,
ENST00000216336
Pharos - Targets
P08311
ZINC - Predictions - Purchasable
CATG_HUMAN
HMDB Protein
HMDBP14055
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q7Z3S9 NT2NA
0.556
3
UniProt:Q9NRD5 PICK1
2
PICK1 [plasma membrane]
(R-HSA-416989)
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
0.556
3
UniProt:Q15323 KRT31
1
KRT31 [cytosol]
(R-HSA-6809616)
0.556
3
UniProt:A8MQ03 CRTP1
0.556
3
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