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STAT3 [cytosol]
Stable Identifier
R-HSA-539044
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Signal transducer and activator of transcription 3, STAT3_HUMAN
Icon
Locations in the PathwayBrowser for interactor UniProt:Q6P1L5 F117B
Expand all
Developmental Biology (Homo sapiens)
Transcriptional regulation of pluripotent stem cells (Homo sapiens)
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation (Homo sapiens)
Expression of STAT3 (Homo sapiens)
STAT3 [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by ALK in cancer (Homo sapiens)
Signaling by ALK fusions and activated point mutants (Homo sapiens)
ALK mutants bind STAT3 (Homo sapiens)
STAT3 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-37 signaling (Homo sapiens)
STAT3 phosphorylation (Homo sapiens)
STAT3 [cytosol] (Homo sapiens)
Interleukin-10 signaling (Homo sapiens)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Homo sapiens)
STAT3 [cytosol] (Homo sapiens)
Interleukin-12 family signaling (Homo sapiens)
Interleukin-23 signaling (Homo sapiens)
STAT3 binds to p-Y-IL23R in IL23:IL23 receptor (Homo sapiens)
STAT3 [cytosol] (Homo sapiens)
Interleukin-27 signaling (Homo sapiens)
STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex (Homo sapiens)
STAT3 [cytosol] (Homo sapiens)
Interleukin-35 Signalling (Homo sapiens)
STAT1,STAT3 associate with IL27RA:IL12RB2 receptor (Homo sapiens)
STAT3 [cytosol] (Homo sapiens)
Interleukin-20 family signaling (Homo sapiens)
IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 (Homo sapiens)
STAT3 [cytosol] (Homo sapiens)
IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 (Homo sapiens)
STAT3 [cytosol] (Homo sapiens)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 (Homo sapiens)
STAT3 [cytosol] (Homo sapiens)
IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 (Homo sapiens)
STAT3 [cytosol] (Homo sapiens)
Interleukin-7 signaling (Homo sapiens)
STAT3 binds TSLP:IL7R:CRLF2 (Homo sapiens)
STAT3 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Leptin (Homo sapiens)
Phosphorylated LEPR Binds STAT3 (Homo sapiens)
STAT3 [cytosol] (Homo sapiens)
Signaling by Non-Receptor Tyrosine Kinases (Homo sapiens)
Signaling by PTK6 (Homo sapiens)
PTK6 Activates STAT3 (Homo sapiens)
STAP2 recruits STAT3 to PTK6 (Homo sapiens)
STAT3 [cytosol] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ALK (Homo sapiens)
STAT3 is phosphorylated downstream of active ALK (Homo sapiens)
STAT3 [cytosol] (Homo sapiens)
Signaling by MET (Homo sapiens)
MET activates STAT3 (Homo sapiens)
STAT3 binds activated MET receptor (Homo sapiens)
STAT3 [cytosol] (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Signalling to STAT3 (Homo sapiens)
STAT3 activation (Homo sapiens)
STAT3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P40763 STAT3
Gene Names
STAT3, APRF
Chain
initiator methionine:, chain:2-770
Reference Genes
BioGPS Gene:6774 STAT3
COSMIC (genes):STAT3 STAT3
CTD Gene:6774 STAT3
dbSNP Gene:6774 STAT3
ENSEMBL:ENSG00000168610 STAT3
ENSEMBL_homo_sapiens_GENE:ENSG00000168610.17 STAT3
HGNC:11364 STAT3
KEGG Gene (Homo sapiens):6774 STAT3
Monarch:6774 STAT3
NCBI Gene:6774 STAT3
OMIM:102582 STAT3
UCSC:P40763 STAT3
Reference Transcript
RefSeq:XM_011525145.2 STAT3
RefSeq:XM_017024972.1 STAT3
RefSeq:NM_003150.3 STAT3
RefSeq:NM_213662.1 STAT3
RefSeq:XM_005257617.3 STAT3
RefSeq:XM_011525146.2 STAT3
RefSeq:NM_139276.2 STAT3
RefSeq:XM_005257616.3 STAT3
RefSeq:XM_017024975.1 STAT3
Other Identifiers
11720755_at
11720756_at
11750674_a_at
16845126
208991_PM_at
208991_at
208992_PM_s_at
208992_s_at
225289_PM_at
225289_at
289_at
3757837
3757839
3757841
3757842
3757844
3757845
3757846
3757848
3757854
3757856
3757858
3757860
3757861
3757862
3757864
3757865
3757867
3757868
3757870
3757871
3757873
3757874
3757875
3757881
3757883
3757885
3757888
3757889
3757905
3757906
39708_at
63330_at
6774
8015607
A_23_P100795
A_23_P107206
A_24_P116805
GE61038
GE61402
GO:0000122
GO:0000785
GO:0000976
GO:0000978
GO:0000981
GO:0001228
GO:0001659
GO:0001754
GO:0002376
GO:0003677
GO:0003700
GO:0003723
GO:0004879
GO:0005102
GO:0005515
GO:0005634
GO:0005654
GO:0005667
GO:0005694
GO:0005737
GO:0005829
GO:0005886
GO:0005975
GO:0006091
GO:0006351
GO:0006355
GO:0006357
GO:0006366
GO:0006606
GO:0006886
GO:0006913
GO:0006914
GO:0006952
GO:0006954
GO:0007165
GO:0007166
GO:0007179
GO:0007259
GO:0007399
GO:0008283
GO:0008285
GO:0010467
GO:0010507
GO:0010575
GO:0010628
GO:0010629
GO:0016071
GO:0016310
GO:0019221
GO:0019901
GO:0019903
GO:0019953
GO:0023052
GO:0030154
GO:0030335
GO:0030522
GO:0031047
GO:0031490
GO:0032355
GO:0032731
GO:0032733
GO:0032755
GO:0032757
GO:0032760
GO:0032870
GO:0032991
GO:0033210
GO:0035019
GO:0035591
GO:0035723
GO:0038110
GO:0038113
GO:0038154
GO:0040014
GO:0042127
GO:0042593
GO:0042755
GO:0042789
GO:0042802
GO:0042803
GO:0043226
GO:0043434
GO:0043491
GO:0043565
GO:0044320
GO:0044321
GO:0045648
GO:0045747
GO:0045766
GO:0045820
GO:0045893
GO:0045944
GO:0046983
GO:0048708
GO:0048856
GO:0048870
GO:0050728
GO:0051092
GO:0051726
GO:0055086
GO:0060019
GO:0060089
GO:0060090
GO:0060221
GO:0060259
GO:0060396
GO:0060397
GO:0061629
GO:0070102
GO:0070878
GO:0071310
GO:0072538
GO:0072540
GO:0090575
GO:0097009
GO:0097398
GO:0097696
GO:0106015
GO:0140110
GO:0140297
GO:0140313
GO:0140610
GO:1900017
GO:1901135
GO:1902895
GO:1904685
GO:1905564
GO:2000635
GO:2000737
GO:2001223
HMNXSV003017485
Hs.288544.0.S1_3p_at
ILMN_1663618
ILMN_2401978
ILMN_2410986
L29277_at
PH_hs_0019532
PH_hs_0025138
TC17001531.hg
TC17002638.hg
g12653684_3p_a_at
Participates
as a component of
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3 [plasma membrane] (Homo sapiens)
IL35:IL27RA:p-JAK1:IL12RB2:p-JAK2:STAT1:STAT3 [plasma membrane] (Homo sapiens)
IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-Y-TYK2:STAT1:STAT3 [plasma membrane] (Homo sapiens)
IL24:IL22RA1:p-JAK1:IL20RB:STAT3 [plasma membrane] (Homo sapiens)
IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3:STAT3 [plasma membrane] (Homo sapiens)
IL7R:TSLP:CRLF2:STAT3 [plasma membrane] (Homo sapiens)
STAT3-activating ALK mutants:STAT3 [cytosol] (Homo sapiens)
p-Y342-PTK6:p-Y250-STAP2:STAT3 [cytosol] (Homo sapiens)
LEP:p-LEPR:p-JAK2:STAT3 [plasma membrane] (Homo sapiens)
HGF:p-4Y-MET dimer:STAT3 [plasma membrane] (Homo sapiens)
STAT3:STAT5A,STAT5B [cytosol] (Homo sapiens)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:STAT3 [plasma membrane] (Homo sapiens)
IL19:IL20RA:p-JAK1:IL20RB:STAT3 [plasma membrane] (Homo sapiens)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:STAT3 [plasma membrane] (Homo sapiens)
as an input of
STAT3 binds to p-Y-IL23R in IL23:IL23 receptor (Homo sapiens)
STAT1,STAT3 associate with IL27RA:IL12RB2 receptor (Homo sapiens)
STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex (Homo sapiens)
IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 (Homo sapiens)
IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 (Homo sapiens)
STAT3 binds TSLP:IL7R:CRLF2 (Homo sapiens)
ALK mutants bind STAT3 (Homo sapiens)
STAP2 recruits STAT3 to PTK6 (Homo sapiens)
Phosphorylated LEPR Binds STAT3 (Homo sapiens)
STAT3 binds activated MET receptor (Homo sapiens)
STAT3 phosphorylation (Homo sapiens)
STAT3 activation (Homo sapiens)
STAT3 is phosphorylated downstream of active ALK (Homo sapiens)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Homo sapiens)
IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 (Homo sapiens)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 (Homo sapiens)
as an output of
Expression of STAT3 (Homo sapiens)
as a member of
STAT1,STAT3,STAT6 [cytosol] (Homo sapiens)
STAT1, STAT2, STAT3, STAT4, STAT5 [cytosol] (Homo sapiens)
STAT1, STAT3, STAT5 [cytosol] (Homo sapiens)
STAT3,STAT6 [cytosol] (Homo sapiens)
STAT family members [cytosol] (Homo sapiens)
STAT1,STAT3,STAT4,STAT5 [cytosol] (Homo sapiens)
STATs [cytosol] (Homo sapiens)
STAT3,STAT5,(STAT3:STAT5) [cytosol] (Homo sapiens)
STAT1, STAT3 [cytosol] (Homo sapiens)
Other forms of this molecule
Unfolded STAT3 [cytosol]
p-STAT3 [nucleoplasm]
p-STAT3 [cytosol]
AcK685- p-Y705,S727-STAT3 [nucleoplasm]
p-Y705,S727-STAT3 [nucleoplasm]
p-S727-STAT3 [cytosol]
p-Y705,S727-STAT3 [cytosol]
p-Y705-STAT3 [nucleoplasm]
p-Y705-STAT3 [cytosol]
p-Y705-STAT3 [cytosol]
p-Y705-STAT3 [nucleoplasm]
Inferred To
dstD [cytosol]
(Dictyostelium discoideum)
dstC [cytosol]
(Dictyostelium discoideum)
Homologues of STAT3 [cytosol]
(Caenorhabditis elegans)
Homologues of STAT3 [cytosol]
(Dictyostelium discoideum)
Homologues of STAT3 [cytosol]
(Sus scrofa)
sta-2 [cytosol]
(Caenorhabditis elegans)
stat3 [cytosol]
(Xenopus tropicalis)
dstB [cytosol]
(Dictyostelium discoideum)
Stat3 [cytosol]
(Mus musculus)
Stat3 [cytosol]
(Rattus norvegicus)
STAT3 [cytosol]
(Bos taurus)
STAT3 [cytosol]
(Caenorhabditis elegans)
STAT3 [cytosol]
(Canis familiaris)
STAT3 [cytosol]
(Dictyostelium discoideum)
STAT3 [cytosol]
(Gallus gallus)
STAT3 [cytosol]
(Sus scrofa)
Stat92E [cytosol]
(Drosophila melanogaster)
dstA [cytosol]
(Dictyostelium discoideum)
sta-1 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
XP_016880464.1
,
XP_011523447.1
,
XP_011523448.1
,
NP_644805.1
,
XP_005257673.2
,
NP_998827.1
,
XP_005257674.2
,
XP_016880461.1
,
NP_003141.2
ZINC - World Drugs
STAT3_HUMAN
Guide to Pharmacology - Targets
2994
OpenTargets
ENSG00000168610
ZINC - Substances
STAT3_HUMAN
ZINC target
P40763
ZINC - Biogenic
STAT3_HUMAN
PRO
P40763
PDB
6NUQ
,
6TLC
,
6NJS
,
6QHD
,
5U5S
,
5AX3
ZINC - Investigational
STAT3_HUMAN
ZINC - Metabolites
STAT3_HUMAN
GeneCards
P40763
HPA
ENSG00000168610-STAT3
Ensembl
ENST00000677723
,
ENSP00000503102
,
ENSP00000503574
,
ENSP00000467000
,
ENSP00000503662
,
ENST00000678960
,
ENST00000679014
,
ENST00000264657
,
ENSG00000168610
,
ENSP00000384943
,
ENST00000678906
,
ENST00000678827
,
ENST00000588969
,
ENST00000585517
,
ENST00000404395
,
ENSP00000503181
,
ENSP00000503237
,
ENST00000677030
,
ENSP00000503634
,
ENSP00000264657
,
ENST00000678044
,
ENSP00000504184
,
ENSP00000467985
Pharos - Targets
P40763
Orphanet
16805
ZINC - Predictions - Purchasable
STAT3_HUMAN
Interactors (88)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.919
15
UniProt:P42224 STAT1
8
p-STAT1 [nucleoplasm]
(R-HSA-8987140)
p-STAT1 [cytosol]
(R-HSA-8950418)
p-Y701,S727-STAT1 [cytosol]
(R-HSA-9850842)
p-Y701-STAT1 [nucleoplasm]
(R-HSA-6788624)
p-Y701-STAT1 [nucleoplasm]
(R-HSA-8985905)
p-Y701-STAT1 [cytosol]
(R-HSA-8951202)
p-Y701-STAT1 [cytosol]
(R-HSA-3132766)
STAT1 [cytosol]
(R-HSA-629622)
0.908
10
UniProt:P43405 SYK
6
p-Y-SYK [cytosol]
(R-HSA-9705732)
p-Y-SYK [plasma membrane]
(R-HSA-429432)
SYK [plasma membrane]
(R-HSA-139844)
p-6Y-SYK [cytosol]
(R-HSA-1861712)
p-Y348-SYK [cytosol]
(R-HSA-437953)
SYK [cytosol]
(R-HSA-58268)
0.873
10
UniProt:P40763 STAT3
12
Unfolded STAT3 [cytosol]
(R-HSA-6813811)
p-STAT3 [nucleoplasm]
(R-HSA-8983188)
p-STAT3 [cytosol]
(R-HSA-8982823)
AcK685- p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701435)
p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701429)
p-S727-STAT3 [cytosol]
(R-HSA-198705)
p-Y705,S727-STAT3 [cytosol]
(R-HSA-539048)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-9027589)
p-Y705-STAT3 [cytosol]
(R-HSA-8983130)
STAT3 [cytosol]
(R-HSA-539044)
p-Y705-STAT3 [cytosol]
(R-HSA-914048)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-1112554)
0.842
8
UniProt:P51813 BMX
3
BMX(1-242) [cytosol]
(R-HSA-351899)
BMX [cytosol]
(R-HSA-351917)
BMX(243-675) [cytosol]
(R-HSA-351875)
0.83
8
UniProt:P51451 BLK
2
MyrG2-BLK [plasma membrane]
(R-HSA-9606871)
BLK [cytosol]
(R-HSA-983580)
0.83
9
UniProt:P04626 ERBB2
20
ERBB2 G309E [plasma membrane]
(R-HSA-9665342)
ERBB2 G309A [plasma membrane]
(R-HSA-9665349)
ERBB2 S310F [plasma membrane]
(R-HSA-9665350)
ERBB2 S310Y [plasma membrane]
(R-HSA-9665344)
p-6Y-ERBB2 G309A [plasma membrane]
(R-HSA-9665381)
p-6Y-ERBB2 G309E [plasma membrane]
(R-HSA-9665382)
p-6Y-ERBB2 S310F [plasma membrane]
(R-HSA-9665379)
p-6Y-ERBB2 S310Y [plasma membrane]
(R-HSA-9665385)
p-Y-ERBB2 L755P [plasma membrane]
(R-HSA-9654268)
p-Y-ERBB2 I767M [plasma membrane]
(R-HSA-9654303)
p-Y-ERBB2 T798I [plasma membrane]
(R-HSA-9654618)
p-Y-ERBB2 Y772_A775dup [plasma membrane]
(R-HSA-9665652)
p-Y-ERBB2 T862A [plasma membrane]
(R-HSA-9654695)
p-Y-ERBB2 T798M [plasma membrane]
(R-HSA-9654615)
p-Y-ERBB2 H878Y [plasma membrane]
(R-HSA-9654833)
p-Y-ERBB2 V777L [plasma membrane]
(R-HSA-9654401)
p-Y-ERBB2 L755S [plasma membrane]
(R-HSA-9654194)
p-Y-ERBB2 V777E [plasma membrane]
(R-HSA-9654397)
p-Y-ERBB2 V777M [plasma membrane]
(R-HSA-9654398)
p-Y-ERBB2 L755M [plasma membrane]
(R-HSA-9654191)
0.775
9
IntAct:EBI-1550784 CDKN1A
0.725
6
UniProt:P08047 SP1
1
SP1 [nucleoplasm]
(R-HSA-1592223)
0.649
4
UniProt:Q8TAE8 GADD45GIP1
1
GADD45GIP1 [mitochondrial matrix]
(R-HSA-5368253)
0.635
4
UniProt:P30626 SRI
1
SRI [sarcoplasmic reticulum membrane]
(R-HSA-5490313)
0.635
3
UniProt:Q16236 NFE2L2
13
p-S,T,S558-NFE2L2 [nucleoplasm]
(R-HSA-9795736)
p-S40, S344, S347- NFE2L2 [nucleoplasm]
(R-HSA-9762050)
p-S344, S347,T-NFE2L2 [nucleoplasm]
(R-HSA-9762048)
ub-p-S40, S335, S338- NFE2L2 [nucleoplasm]
(R-HSA-9762058)
ub-p-S335, S338,T-NFE2L2 [nucleoplasm]
(R-HSA-9762055)
ub-NFE2L2 [cytosol]
(R-HSA-9758077)
p-S40-18 AcK-NFE2L2 [nucleoplasm]
(R-HSA-9760018)
p-S,T-18 AcK-NFE2L2 [nucleoplasm]
(R-HSA-9760033)
NFE2L2 [cytosol]
(R-HSA-201566)
p-S,T-NFE2L2 [cytosol]
(R-HSA-8932311)
p-S40-NFE2L2 [cytosol]
(R-HSA-8932290)
p-S,T-NFE2L2 [nucleoplasm]
(R-HSA-9715110)
p-S40-NFE2L2 [nucleoplasm]
(R-HSA-9715109)
0.625
5
UniProt:P06401 PGR
3
monoSUMO1-K7,K388,K531-PGR [nucleoplasm]
(R-HSA-4341032)
PGR [cytosol]
(R-HSA-8948964)
PGR [nucleoplasm]
(R-HSA-3008952)
0.623
3
UniProt:P18031 PTPN1
2
PTPN1 [cytosol]
(R-HSA-210625)
PTPN1 [endosome membrane]
(R-HSA-9815895)
0.623
2
UniProt:P45984-1 MAPK9
0.602
3
UniProt:Q810M5 ZDH19
0.576
4
UniProt:P23458 JAK1
6
p-Y1034,Y1035-JAK1 [cytosol]
(R-HSA-9005335)
JAK1 [endosome]
(R-HSA-8983168)
p-JAK1 [cytosol]
(R-HSA-8950711)
p-Y1034-JAK1 [cytosol]
(R-HSA-1112543)
JAK1 [cytosol]
(R-HSA-451898)
p-Y-JAK1 [cytosol]
(R-HSA-451921)
0.564
2
UniProt:O43318 MAP3K7
10
PolyUb-MAP3K7 [cytosol]
(R-HSA-6782968)
MAP3K7 [plasma membrane]
(R-HSA-9012677)
K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol]
(R-HSA-5607649)
K63polyUb-34,158-TAK1 [cytosol]
(R-HSA-5607643)
p-MAP3K7 [cytosol]
(R-HSA-168163)
p-T187-MAP3K7 [cytosol]
(R-HSA-206014)
MAP3K7 [endosome membrane]
(R-HSA-450315)
p-T184,T187-MAP3K7 [endosome membrane]
(R-HSA-450332)
MAP3K7 [cytosol]
(R-HSA-168156)
p-T184,T187-MAP3K7 [cytosol]
(R-HSA-202527)
0.558
4
UniProt:P25791 LMO2
1
LMO2 [nucleoplasm]
(R-HSA-8956513)
0.556
3
UniProt:Q9DUM3 Q9DUM3
0.556
4
UniProt:Q96HA1-2 POM121
0.556
3
IntAct:EBI-10178797 4005
0.556
3
UniProt:P12268 IMPDH2
4
IMPDH2 [secretory granule lumen]
(R-HSA-6803323)
IMPDH2 [extracellular region]
(R-HSA-6806455)
IMPDH2 [ficolin-1-rich granule lumen]
(R-HSA-6803330)
IMPDH2 [cytosol]
(R-HSA-57350)
0.556
3
UniProt:Q9UER7 DAXX
13
monoSUMO1-K630,K631-DAXX [nucleoplasm]
(R-HSA-4086086)
DAXX L98Vfs*13 [nucleoplasm]
(R-HSA-9673102)
DAXX R48Vfs*93 [nucleoplasm]
(R-HSA-9673103)
DAXX C74* [nucleoplasm]
(R-HSA-9673096)
DAXX S138* [nucleoplasm]
(R-HSA-9673081)
DAXX H26Tfs*118 [nucleoplasm]
(R-HSA-9673114)
DAXX E104* [nucleoplasm]
(R-HSA-9673078)
DAXX E72Nfs*72 [nucleoplasm]
(R-HSA-9673110)
DAXX C106* [nucleoplasm]
(R-HSA-9673079)
DAXX A103Sfs*40 [nucleoplasm]
(R-HSA-9673121)
DAXX K56* [nucleoplasm]
(R-HSA-9673089)
DAXX A36Qfs*108 [nucleoplasm]
(R-HSA-9673105)
DAXX [nucleoplasm]
(R-HSA-3222068)
0.556
4
UniProt:Q9BXM7 PINK1
5
p-S228,S402-PINK1 [mitochondrial outer membrane]
(R-HSA-9834051)
PINK1 [mitochondrial outer membrane]
(R-HSA-5205653)
PINK1 [mitochondrial intermembrane space]
(R-HSA-5205671)
PINK1 [cytosol]
(R-HSA-5205637)
PINK1(111-581) [mitochondrial intermembrane space]
(R-HSA-5205628)
0.547
2
UniProt:Q8N6P7 IL22RA1
2
IL22RA1 [plasma membrane]
(R-HSA-448489)
p-Y-251,p-Y301-IL22RA1 [plasma membrane]
(R-HSA-8987198)
0.547
2
IntAct:EBI-9914958 STAT3
0.527
3
IntAct:EBI-1265559 MYC
0.527
3
UniProt:Q14289 PTK2B
3
p-Y-PTK2B [cytosol]
(R-HSA-508515)
PTK2B [cytosol]
(R-HSA-390932)
PTK2B [cytosol]
(R-HSA-5218721)
0.527
4
UniProt:P12931 SRC
6
p-Y419-SRC [nucleoplasm]
(R-HSA-8937690)
SRC [cytosol]
(R-HSA-9628701)
p-Y419-SRC [cytosol]
(R-HSA-8964276)
MyrG-SRC [plasma membrane]
(R-HSA-8876922)
MyrG,p-Y530-SRC [plasma membrane]
(R-HSA-377598)
MyrG-p-Y419-SRC [plasma membrane]
(R-HSA-1810408)
0.527
5
UniProt:O75116 ROCK2
2
ROCK2 [cytosol]
(R-HSA-419058)
Activated ROCK2 [cytosol]
(R-HSA-4687775)
0.524
3
UniProt:Q14938-4 NFIX
0.524
3
UniProt:Q14938-3 NFIX
0.524
3
UniProt:Q9Y5S9 RBM8A
2
RBM8A [cytosol]
(R-HSA-162462)
RBM8A [nucleoplasm]
(R-HSA-156659)
0.512
3
UniProt:Q98PK8 Q98PK8
0.512
3
UniProt:Q9BVP2 GNL3
1
GNL3 [nucleoplasm]
(R-HSA-8869324)
0.508
2
UniProt:Q9ULD0 OGDHL
0.508
2
UniProt:Q13011 ECH1
3
ECH1 [mitochondrial matrix]
(R-HSA-9838037)
ECH1(1-328) [peroxisomal matrix]
(R-HSA-9033140)
ECH1(1-328) [cytosol]
(R-HSA-9033152)
0.508
2
UniProt:P07384 CAPN1
4
CAPN1 [plasma membrane]
(R-HSA-3828038)
CAPN1 [cytosol]
(R-HSA-3288367)
CAPN1 [extracellular region]
(R-HSA-6806485)
CAPN1 [ficolin-1-rich granule lumen]
(R-HSA-6801284)
0.508
2
UniProt:P30084 ECHS1
17
Q159R ECHS1 [mitochondrial matrix]
(R-HSA-9916666)
F33S ECHS1 [mitochondrial matrix]
(R-HSA-9916682)
E77Q ECHS1 [mitochondrial matrix]
(R-HSA-9916667)
A138V ECHS1 [mitochondrial matrix]
(R-HSA-9916683)
N59S ECHS1 [mitochondrial matrix]
(R-HSA-9916684)
C225R ECHS1 [mitochondrial matrix]
(R-HSA-9916672)
ECHS1 [mitochondrial matrix]
(R-HSA-54125)
A2V ECHS1 [mitochondrial matrix]
(R-HSA-9916688)
T180A ECHS1 [mitochondrial matrix]
(R-HSA-9916687)
A238V ECHS1 [mitochondrial matrix]
(R-HSA-9916686)
A132T ECHS1 [mitochondrial matrix]
(R-HSA-9916665)
G195S ECHS1 [mitochondrial matrix]
(R-HSA-9916681)
K273E ECHS1 [mitochondrial matrix]
(R-HSA-9916680)
R54H ECHS1 [mitochondrial matrix]
(R-HSA-9916676)
I66T ECHS1 [mitochondrial matrix]
(R-HSA-9916659)
D150G ECHS1 [mitochondrial matrix]
(R-HSA-9916674)
A158D ECHS1 [mitochondrial matrix]
(R-HSA-9916689)
0.508
3
UniProt:Q92665 MRPS31
1
MRPS31 [mitochondrial inner membrane]
(R-HSA-5368198)
0.508
2
UniProt:Q96G01 BICD1
1
BICD1 [cytosol]
(R-HSA-8848104)
0.508
2
UniProt:Q8TE76 MORC4
0.508
2
UniProt:O14874 BCKDK
5
BCKDK [mitochondrial matrix]
(R-HSA-5693129)
R224P BCKDK [mitochondrial matrix]
(R-HSA-9912466)
R174Gfs1* BCKDK [mitochondrial matrix]
(R-HSA-9912469)
L389P BCKDK [mitochondrial matrix]
(R-HSA-9912461)
R156* BCKDK [mitochondrial matrix]
(R-HSA-9912465)
0.508
2
UniProt:P46781 RPS9
2
RPS9 [nucleoplasm]
(R-HSA-6790663)
RPS9 [cytosol]
(R-HSA-72387)
0.508
2
UniProt:Q06520 SULT2A1
1
SULT2A1 [cytosol]
(R-HSA-176559)
0.508
2
UniProt:P22736 NR4A1
2
p-S351-NR4A1 [nucleoplasm]
(R-HSA-199846)
NR4A1 [nucleoplasm]
(R-HSA-199831)
0.508
3
UniProt:P31146 CORO1A
1
CORO1A [cytosol]
(R-HSA-9636432)
0.508
2
IntAct:EBI-9825772 C-FOS PROMOTER REGION
0.499
2
IntAct:EBI-10039972 MMP2
0.499
2
UniProt:Q9NWQ8 PAG1
2
PAG1 [plasma membrane]
(R-HSA-180500)
p-Y317-PAG1 [plasma membrane]
(R-HSA-180494)
0.499
7
UniProt:P32119 PRDX2
2
p-T89-PRDX2 [cytosol]
(R-HSA-8868574)
PRDX2 [cytosol]
(R-HSA-3341292)
0.499
4
IntAct:EBI-1108795 NPM
0.499
2
IntAct:EBI-9980755 MIR-155
0.499
2
IntAct:EBI-10952519 STAT
0.499
4
UniProt:Q15910 EZH2
1
EZH2 [nucleoplasm]
(R-HSA-212298)
0.499
5
UniProt:Q5VWN6 TASO2
0.488
2
IntAct:EBI-10696506 MPZL1
0.488
2
UniProt:Q92569 PIK3R3
2
PIK3R3 [cytosol]
(R-HSA-205223)
K63polyUb-PIK3R3 [cytosol]
(R-HSA-3080574)
0.488
2
UniProt:Q8NEC7 GSTCD
0.488
2
UniProt:P60409 KRTAP10-7
1
KRTAP10-7 [cytosol]
(R-HSA-6810279)
0.488
2
UniProt:P35219 CAH8
0.488
2
UniProt:Q9Y4J8-9 DTNA
0.488
2
UniProt:P27986-2 PIK3R1
0.488
2
UniProt:Q9NVE4 CCD87
0.488
2
UniProt:Q96DZ7 T4S19
0.488
2
UniProt:Q8IZQ1 WDFY3
0.488
2
UniProt:Q6P1L5 F117B
0.488
2
UniProt:Q86WK9 PAQR7
0.488
2
UniProt:Q14847 LASP1
0.488
2
UniProt:Q03181-2 PPARD
0.488
2
UniProt:Q3KNS6 ZN829
0.488
2
UniProt:Q7L591-3 DOK3
0.488
2
UniProt:Q9UBX0 HESX1
0.488
2
UniProt:Q6ZVU3 Q6ZVU3
0.488
2
UniProt:Q9Y2X9 ZN281
0.488
2
UniProt:Q9NP31 SH2D2A
1
SH2D2A [cytosol]
(R-HSA-4420125)
0.488
2
UniProt:P49137 MAPKAPK2
5
MAPKAPK2 [cytosol]
(R-HSA-187743)
p-T222,S272-MAPKAPK2 [nucleoplasm]
(R-HSA-199936)
p-S272,T222,T334-MAPKAPK2 [cytosol]
(R-HSA-187760)
p-T222,S272,T334-MAPKAPK2 [nucleoplasm]
(R-HSA-450268)
MAPKAPK2 [nucleoplasm]
(R-HSA-450235)
0.488
2
UniProt:Q9Y3P9 RABGAP1
1
RABGAP1 [cytosol]
(R-HSA-8854144)
0.488
2
UniProt:P22681 CBL
20
PolyUb,p-Y-CBL [cytosol]
(R-HSA-9763893)
CBL R420G [cytosol]
(R-HSA-9706203)
CBL R420Q [cytosol]
(R-HSA-9706186)
CBL Y371H [cytosol]
(R-HSA-9706680)
CBL H398Y [cytosol]
(R-HSA-9706639)
CBL P417A [cytosol]
(R-HSA-9706636)
CBL S376F [cytosol]
(R-HSA-9706643)
CBL E366_Q409del [cytosol]
(R-HSA-9706179)
CBL del366-477 [cytosol]
(R-HSA-9706176)
CBL R499L [cytosol]
(R-HSA-9706678)
CBL L380P [cytosol]
(R-HSA-9706630)
CBL L287R [cytosol]
(R-HSA-9706693)
CBL L380R [cytosol]
(R-HSA-9706635)
CBL G375P [cytosol]
(R-HSA-9706219)
CBL P417L [cytosol]
(R-HSA-9706634)
CBL H398Q [cytosol]
(R-HSA-9706633)
CBL P417R [cytosol]
(R-HSA-9706632)
CBL R499* [cytosol]
(R-HSA-9706670)
CBL H398R [cytosol]
(R-HSA-9706638)
CBL H398P [cytosol]
(R-HSA-9706637)
0.488
2
UniProt:Q15672 TWIST1
1
TWIST1 [nucleoplasm]
(R-HSA-445442)
0.488
2
UniProt:P07949 RET
2
RET [plasma membrane]
(R-HSA-8853797)
p-5Y-RET [plasma membrane]
(R-HSA-8854162)
0.483
3
UniProt:O95661 DIRA3
0.463
3
UniProt:Q04206 RELA
7
MeK310-RELA [nucleoplasm]
(R-HSA-8865233)
p-S536-RELA [nucleoplasm]
(R-HSA-9861499)
p-S276,5xAcK-RELA [nucleoplasm]
(R-HSA-5660642)
p-S276-RELA [nucleoplasm]
(R-HSA-5624468)
polySUMO3-K37,K122,K123-RELA [nucleoplasm]
(R-HSA-4755466)
RELA [cytosol]
(R-HSA-168172)
RELA [nucleoplasm]
(R-HSA-177676)
0.463
4
UniProt:P35232 PHB
2
PHB [cytosol]
(R-HSA-5672944)
PHB [mitochondrial inner membrane]
(R-HSA-8953720)
0.463
2
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.462
3
UniProt:Q9UBE8 NLK
3
NLK [cytosol]
(R-HSA-4411330)
p-T298-NLK [cytosol]
(R-HSA-4411398)
p-T298-NLK [nucleoplasm]
(R-HSA-4411376)
0.462
2
UniProt:Q99062 CSF3R
5
K48polyUb-K655,p-4Y-CSF3R [lysosomal membrane]
(R-HSA-9707928)
CSF3R [plasma membrane]
(R-HSA-6787734)
p-4Y-CSF3R [plasma membrane]
(R-HSA-9674543)
p-4Y-CSF3R [endocytic vesicle membrane]
(R-HSA-9705736)
K48polyUb-K655,p-4Y-CSF3R [endocytic vesicle membrane]
(R-HSA-9705727)
0.462
4
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