RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL

Stable Identifier
Reaction [transition]
Homo sapiens
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Multiple reductases may contribute to the reduction of all-trans-retinal (atRAL) to all-trans-retinol (atROL), including RDH11 (aka PSDR1, RalR1), RDH14, DHRS3 (aka retSDR1, RDH17) and DHRS4 (aka RRD, SCAD-SRL) (Haeseleer et al. 1998, Haeseleer et al. 2002, Kedishvili et al. 2002, Lin et al. 2001, Zhen et al. 2003, Belyaeva et al. 2008).
Literature References
PubMed ID Title Journal Year
12680773 Reduction of all-trans-retinal in the mouse liver peroxisome fraction by the short-chain dehydrogenase/reductase RRD: induction by the PPAR alpha ligand clofibrate

Chen, W, Zhang, M, Napoli, JL, Lei, Z

Biochemistry 2003
12226107 Dual-substrate specificity short chain retinol dehydrogenases from the vertebrate retina

Imanishi, Y, Driessen, CA, Nelson, PS, Palczewski, K, Haeseleer, F, Jang, GF, Matsumura, M

J. Biol. Chem. 2002
9705317 Molecular characterization of a novel short-chain dehydrogenase/reductase that reduces all-trans-retinal

Lebioda, L, Huang, J, Saari, JC, Haeseleer, F, Palczewski, K

J. Biol. Chem. 1998
18039331 Human retinol dehydrogenase 13 (RDH13) is a mitochondrial short-chain dehydrogenase/reductase with a retinaldehyde reductase activity

Belyaeva, OV, Korkina, OV, Stetsenko, AV, Kedishvili, NY

FEBS J. 2008
11245473 Prostate short-chain dehydrogenase reductase 1 (PSDR1): a new member of the short-chain steroid dehydrogenase/reductase family highly expressed in normal and neoplastic prostate epithelium

Vessella, R, Wang, S, Ferguson, C, Bumgarner, R, Lin, B, Hood, L, True, LD, Nelson, PS, White, JT

Cancer Res. 2001
12036956 Evidence that the human gene for prostate short-chain dehydrogenase/reductase (PSDR1) encodes a novel retinal reductase (RalR1)

Belyaeva, OV, Lin, DW, Nelson, PS, Chumakova, OV, Chetyrkin, SV, Matsumura, M, Lapshina, EA, Kedishvili, NY

J. Biol. Chem. 2002
Catalyst Activity

NADP-retinol dehydrogenase activity of RDH11,14,DHRS3,DHRS4 [endoplasmic reticulum membrane]

Orthologous Events
Cross References
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