Reactome | MRRF [mitochondrial matrix]

MRRF [mitochondrial matrix]

Stable Identifier

R-HSA-5419265

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

Ribosome-recycling factor, mitochondrial, RRFM_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P14373 TRIM27

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External Reference Information

External Reference

UniProt:Q96E11 MRRF

Gene Names

MRRF

Chain

transit peptide:1-55, chain:56-262

Reference Genes

BioGPS Gene:92399 MRRF

COSMIC (genes):MRRF MRRF

CTD Gene:92399 MRRF

dbSNP Gene:92399 MRRF

ENSEMBL:ENSG00000148187 MRRF

ENSEMBL:ENSG00000148187.18 MRRF

HGNC:7234 MRRF

KEGG Gene (Homo sapiens):92399 MRRF

Monarch:92399 MRRF

NCBI Gene:92399 MRRF

OMIM:604602 MRRF

UCSC:Q96E11 MRRF

Reference Transcript

Other Identifiers

11747410_a_at

11751453_a_at

11760918_a_at

225126_PM_at

225126_at

239498_PM_at

239498_at

3188051

3188052

3188053

3188057

3188058

3188059

3188060

3188061

3188065

3188068

3188070

3188071

3188072

3188075

3188083

3188088

3188089

3188090

3188091

3188092

3188094

3188095

3188096

3188097

3188098

3188099

3188101

4020381

4020382

43647_at

55739_at

8157638

86920_at

92399

A_24_P175427

A_32_P218992

A_33_P3398809

GE79327

GO:0005515

GO:0005739

GO:0005759

GO:0006412

GO:0032790

GO:0043023

GO:0043226

HMNXSV003034819

HMNXSV003045788

Hs.19777.0.A1_3p_at

Hs.99756.0.A1_3p_at

ILMN_1680675

ILMN_1701306

ILMN_2298958

ILMN_2415949

PH_hs_0005568

TC09000613.hg

p16908

p16909

Participates

as an output of

Hydrolysis of GTP and dissociation of 28S and 39S subunits (Homo sapiens)

as a component of

as an input of

MRRF binds 55S ribosome:mRNA:tRNA (Homo sapiens)

Inferred To

mrrf-1 [mitochondrial matrix] (Caenorhabditis elegans)

Ghost homologue of MRRF [mitochondrial matrix] (Xenopus tropicalis)

mRRF1 [mitochondrial matrix] (Drosophila melanogaster)

Mrrf [mitochondrial matrix] (Mus musculus)

Mrrf [mitochondrial matrix] (Rattus norvegicus)

MRRF [mitochondrial matrix] (Bos taurus)

MRRF [mitochondrial matrix] (Canis familiaris)

MRRF [mitochondrial matrix] (Danio rerio)

MRRF [mitochondrial matrix] (Sus scrofa)

MRRFP1 [mitochondrial matrix] (Gallus gallus)

Cross References

RefSeq

NP_620132.1, NP_001333272.1, NP_001333270.1, NP_001166983.1, NP_954646.1

OpenTargets

ENSG00000148187

GeneCards

Q96E11

HPA

ENSG00000148187-MRRF

Ensembl

ENST00000394315, ENST00000297908, ENST00000373729, ENSP00000362828, ENSP00000362834, ENST00000489572, ENST00000467864, ENST00000373723, ENSP00000434807, ENSP00000433288, ENST00000470366, ENSP00000377850, ENSP00000297908, ENSG00000148187, ENSP00000343867, ENSP00000436360, ENST00000344641

PRO

Q96E11

Pharos - Targets

Q96E11

Orphanet

27477

PDB

7L20, 7NSH, 6NU2, 7NSI, 7L08, 6ZS9

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96DZ9-2 CMTM5			0.556	3
UniProt:Q8IZU0 FAM9B			0.556	3
UniProt:Q6A162 KRT40	1	KRT40 [cytosol] (R-HSA-6809605)	0.556	3
UniProt:Q9Y4P8-4 WIPI2			0.556	3
UniProt:Q9H9D4 ZN408			0.556	3
UniProt:Q8N9N5-2 BANP			0.556	3
UniProt:P08247 SYP	1	SYP [clathrin-sculpted glutamate transport vesicle membrane] (R-HSA-5215991)	0.556	3
UniProt:Q6RW13-2 AGTRAP			0.556	3
UniProt:Q13643 FHL3			0.556	3
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.553	2

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