Reactome | CDC5L [nucleoplasm]

CDC5L [nucleoplasm]

Stable Identifier

R-HSA-5420887

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Cell division cycle 5-like protein, CDC5L_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q99459 CDC5L

Gene Names

CDC5L, KIAA0432, PCDC5RP

Chain

chain:1-802

Reference Genes

BioGPS Gene:988 CDC5L

COSMIC (genes):CDC5L CDC5L

CTD Gene:988 CDC5L

dbSNP Gene:988 CDC5L

ENSEMBL:ENSG00000096401 CDC5L

HGNC:1743 CDC5L

KEGG:hsa:988 CDC5L

Monarch:988 CDC5L

NCBI Gene:988 CDC5L

OMIM:602868 CDC5L

UCSC:Q99459 CDC5L

Reference Transcript

RefSeq:NM_001253.3 CDC5L

Other Identifiers

11719080_a_at

11719081_a_at

1621_at

17009262

209055_PM_s_at

209055_s_at

209056_PM_s_at

209056_s_at

209057_PM_x_at

209057_x_at

2908573

2908574

2908575

2908576

2908577

2908579

2908580

2908581

2908582

2908584

2908585

2908587

2908588

2908589

2908590

2908591

2908592

2908594

2908600

2908601

2908602

2908603

2908604

32040_i_at

32041_r_at

8120022

988

A_14_P100735

A_14_P125269

A_23_P156471

A_32_P55804

D85423_at

GE53182

GO:0000077

GO:0000398

GO:0000974

GO:0000977

GO:0000981

GO:0001228

GO:0003677

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005662

GO:0005681

GO:0005737

GO:0006281

GO:0006355

GO:0006357

GO:0006397

GO:0008380

GO:0016020

GO:0016071

GO:0016607

GO:0042802

GO:0043226

GO:0045944

GO:0071007

GO:0071013

GO:0071987

GO:0140110

HMNXSV003040452

Hs.155174.0.S1_3p_a_at

Hs.155174.0.S2_3p_a_at

ILMN_1652907

PH_hs_0025923

TC06000617.hg

g2887434_3p_a_at

Participates

as a component of

PRP19-CDC5L complex [nucleoplasm] (Homo sapiens)

Inferred To

Ghost homologue of CDC5L [nucleoplasm] (Danio rerio)

cdc-5l [nucleoplasm] (Caenorhabditis elegans)

Cdc5 [nucleoplasm] (Drosophila melanogaster)

Cdc5l [nucleoplasm] (Mus musculus)

Cdc5l [nucleoplasm] (Rattus norvegicus)

CDC5L [nucleoplasm] (Bos taurus)

CDC5L [nucleoplasm] (Canis familiaris)

CDC5L [nucleoplasm] (Gallus gallus)

CDC5L [nucleoplasm] (Plasmodium falciparum)

CDC5L [nucleoplasm] (Sus scrofa)

cdc5 [nucleoplasm] (Schizosaccharomyces pombe)

cdc5l [nucleoplasm] (Dictyostelium discoideum)

cdc5l [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001244.1

OpenTargets

ENSG00000096401

ENSEMBL

ENSP00000360532, ENST00000371477

HPA

ENSG00000096401-CDC5L

PRO

Q99459

Pharos - Targets

Q99459

GlyGen

Q99459

PDB

6ID0, 6FF4, 5XJC, 6FF7, 6ID1, 7W5B, 7ABG, 8CH6, 7QTT, 7W5A, 6QDV, 5Z56, 7ABH, 6ZYM, 7ABI, 5Z57, 2DIN, 5YZG, 2DIM, 7W59, 7A5P, 5MQF, 6ICZ, 7AAV, 8C6J, 7DVQ, 5Z58

Interactors (33)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P07910 HNRNPC	3	HNRNPC [nucleoplasm] (R-HSA-71933) SUMO1-K250-HNRNPC [nucleoplasm] (R-HSA-4570543) HNRNPC [cytosol] (R-HSA-9715136)	0.731	4
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.718	6
UniProt:P11142 HSPA8	10	HSPA8 [cytosol] (R-HSA-264476) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217)	0.709	5
UniProt:O60341 KDM1A	1	KDM1A [nucleoplasm] (R-HSA-996769)	0.667	3
UniProt:Q7Z3B3 KANSL1	1	KANSL1 [nucleoplasm] (R-HSA-3321875)	0.667	3
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.643	5
UniProt:P62304 SNRPE	2	SNRPE [cytosol] (R-HSA-191782) SNRPE [nucleoplasm] (R-HSA-71905)	0.643	5
UniProt:P52272 HNRNPM	1	HNRNPM [nucleoplasm] (R-HSA-71949)	0.631	7
UniProt:Q13416 ORC2	1	ORC2 [nucleoplasm] (R-HSA-68405)	0.59	2
UniProt:P62136 PPP1CA	1	PPP1CA [cytosol] (R-HSA-163525)	0.59	2
UniProt:Q9CSN1 Snw1	1	Snw1 [nucleoplasm] (R-MMU-2065315)	0.564	2
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:P40222 TXLNA	1	TXLNA [cytosol] (R-HSA-449124)	0.556	3
UniProt:Q9UGI0 ZRANB1	1	ZRANB1 [cytosol] (R-HSA-6781939)	0.556	3
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.553	2
UniProt:Q9UPT5 EXOC7	2	EXOC7 [cytosol] (R-HSA-5623386) EXOC7 [plasma membrane] (R-HSA-2872288)	0.547	2
UniProt:Q9Y5B9 SUPT16H	1	SUPT16H [nucleoplasm] (R-HSA-112415)	0.547	2
UniProt:Q13535 ATR	1	ATR [nucleoplasm] (R-HSA-912443)	0.544	3
UniProt:O75533 SF3B1	1	SF3B1 [nucleoplasm] (R-HSA-71968)	0.527	2
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	4
UniProt:Q13523 PRPF4B	1	PRPF4B [nucleoplasm] (R-HSA-9769525)	0.527	2
UniProt:Q13616 CUL1	3	CUL1 [cytosol] (R-HSA-174230) CUL1 [nucleoplasm] (R-HSA-187551) G76-NEDD8-K720-CUL1 [cytosol] (R-HSA-8952519)	0.527	2
UniProt:P38919 EIF4A3	2	EIF4A3 [nucleoplasm] (R-HSA-8849149) EIF4A3 [cytosol] (R-HSA-927868)	0.527	2
UniProt:Q9UJV9 DDX41	4	DDX41 [nucleoplasm] (R-HSA-9769601) DDX41 [cytosol] (R-HSA-3134807) K48polyUb-DDX41 [cytosol] (R-HSA-3134942) K48polyUb-DDX41 [cytosol] (R-HSA-3134941)	0.527	2
UniProt:O95926 SYF2	1	SYF2 [nucleoplasm] (R-HSA-8867884)	0.527	3
UniProt:P09661 SNRPA1	1	SNRPA1 [nucleoplasm] (R-HSA-71958)	0.527	2
UniProt:Q16629 SRSF7	1	SRSF7 [nucleoplasm] (R-HSA-72029)	0.527	2
UniProt:Q9H9Z2 LIN28A	1	LIN28A [cytosol] (R-HSA-500391)	0.527	2
UniProt:Q9BW85 YJU2	1	YJU2 [nucleoplasm] (R-HSA-9770430)	0.527	2
UniProt:Q14498 RBM39	1	RBM39 [nucleoplasm] (R-HSA-9770254)	0.527	2
UniProt:Q12972 PPP1R8	1	PPP1R8 [nucleoplasm] (R-HSA-9770253)	0.508	2
UniProt:Q07955 SRSF1	1	SRSF1 [nucleoplasm] (R-HSA-72031)	0.483	2
UniProt:P06748 NPM1	11	NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [granular component] (R-HSA-9017702) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.483	2

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