Reactome | BCAS2 [nucleoplasm]

BCAS2 [nucleoplasm]

Stable Identifier

R-HSA-5420902

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Pre-mRNA-splicing factor SPF27, SPF27_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Dengue Virus Infection (Homo sapiens)
      - Dengue Virus-Host Interactions (Homo sapiens)
        
        NS5 interacts with Spliceosome (Homo sapiens)
        
        NS5:Spliceosomal Intermediate C Complex [nucleoplasm] (Homo sapiens)
        
        Spliceosomal Intermediate C Complex [nucleoplasm] (Homo sapiens)
        
        PRP19-CDC5L complex [nucleoplasm] (Homo sapiens)
        
        BCAS2 [nucleoplasm] (Homo sapiens)
        
        Spliceosomal Intermediate C Complex [nucleoplasm] (Homo sapiens)
        
        PRP19-CDC5L complex [nucleoplasm] (Homo sapiens)
        
        BCAS2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O75934 BCAS2

Gene Names

BCAS2, DAM1

Chain

initiator methionine:1, chain:2-225

Reference Genes

BioGPS Gene:10286 BCAS2

COSMIC (genes):BCAS2 BCAS2

CTD Gene:10286 BCAS2

dbSNP Gene:10286 BCAS2

ENSEMBL:ENSG00000116752 BCAS2

HGNC:975 BCAS2

KEGG:hsa:10286 BCAS2

Monarch:10286 BCAS2

NCBI Gene:10286 BCAS2

OMIM:605783 BCAS2

UCSC:O75934 BCAS2

Reference Transcript

RefSeq:NM_005872.3 BCAS2

Other Identifiers

10286

11742764_at

16691204

203053_PM_at

203053_at

2425292

2429165

2429166

2429167

2429168

2429169

2429170

2429172

2429173

2429176

2429178

2429179

2429180

2429181

2692163

34286_at

7918759

A_23_P34930

GE53520

GO:0000375

GO:0000380

GO:0000398

GO:0000974

GO:0001541

GO:0005515

GO:0005634

GO:0005654

GO:0005662

GO:0005681

GO:0005730

GO:0005813

GO:0005815

GO:0006397

GO:0007010

GO:0008380

GO:0016071

GO:0016607

GO:0022414

GO:0030163

GO:0048477

GO:0048599

GO:0048856

GO:0051225

GO:0071007

GO:0071013

HMNXSV003044243

ILMN_1751760

ILMN_2148452

PH_hs_0031073

TC01006365.hg

g5031652_3p_at

Participates

as a component of

PRP19-CDC5L complex [nucleoplasm] (Homo sapiens)

Inferred To

cwf7 [nucleoplasm] (Schizosaccharomyces pombe)

spf27 [nucleoplasm] (Dictyostelium discoideum)

Bcas2 [nucleoplasm] (Mus musculus)

Bcas2 [nucleoplasm] (Rattus norvegicus)

BCAS2 [nucleoplasm] (Bos taurus)

BCAS2 [nucleoplasm] (Canis familiaris)

BCAS2 [nucleoplasm] (Drosophila melanogaster)

BCAS2 [nucleoplasm] (Gallus gallus)

BCAS2 [nucleoplasm] (Plasmodium falciparum)

BCAS2 [nucleoplasm] (Sus scrofa)

bcas-2 [nucleoplasm] (Caenorhabditis elegans)

bcas2 [nucleoplasm] (Danio rerio)

bcas2 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_005863.1

OpenTargets

ENSG00000116752

ENSEMBL

ENST00000369541, ENSG00000116752, ENSP00000358554

HPA

ENSG00000116752-BCAS2

GeneCards

BCAS2

PRO

O75934

Pharos - Targets

O75934

GlyGen

O75934

PDB

8I0V, 6ICZ, 8I0T, 9FMD, 8I0U, 7A5P, 6FF7, 7W59, 6ID0, 8RO2, 5YZG, 5Z56, 5Z57, 6ID1, 8C6J, 8I0W, 6QDV, 7W5A, 8CH6, 7W5B, 5XJC, 5MQF

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.841	9
UniProt:O14964 HGS	2	HGS [cytosol] (R-HSA-182954) HGS [phagocytic vesicle lumen] (R-HSA-9635660)	0.666	4
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.643	4
UniProt:Q96GM5 SMARCD1	1	SMARCD1 [nucleoplasm] (R-HSA-389255)	0.556	3
UniProt:Q99757 TXN2	2	TXN2 [mitochondrial matrix] (R-HSA-3323048) 2xHC-TXN2 [mitochondrial matrix] (R-HSA-3323059)	0.556	3
UniProt:P14136 GFAP	3	p-GFAP [lysosomal membrane] (R-HSA-9626054) GFAP [lysosomal membrane] (R-HSA-9625195) GFAP [cytosol] (R-HSA-1253311)	0.556	3
UniProt:Q02548 PAX5	1	PAX5 [nucleoplasm] (R-HSA-158583)	0.556	3
UniProt:Q14562 DHX8	1	DHX8 [nucleoplasm] (R-HSA-5688092)	0.527	2
UniProt:P06748 NPM1	11	NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [granular component] (R-HSA-9017702) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.527	2
UniProt:O60508 CDC40	1	CDC40 [nucleoplasm] (R-HSA-72062)	0.527	3
UniProt:O75533 SF3B1	1	SF3B1 [nucleoplasm] (R-HSA-71968)	0.527	3
UniProt:Q9BW85 YJU2	1	YJU2 [nucleoplasm] (R-HSA-9770430)	0.527	2
UniProt:Q8WUD4 CCDC12	1	CCDC12 [nucleoplasm] (R-HSA-9769561)	0.527	3
UniProt:O95926 SYF2	1	SYF2 [nucleoplasm] (R-HSA-8867884)	0.527	3
UniProt:Q9H9Z2 LIN28A	1	LIN28A [cytosol] (R-HSA-500391)	0.527	2
UniProt:Q13077 TRAF1	3	TRAF1 [cytosol] (R-HSA-5634163) TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.488	2

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