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ELL [nucleoplasm]
Stable Identifier
R-HSA-54257
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
RNA polymerase II elongation factor ELL, Eleven-nineteen lysine-rich leukemia protein
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
Nucleotide Excision Repair (Homo sapiens)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Homo sapiens)
Recovery of RNA synthesis after TC-NER (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
HIV Infection (Homo sapiens)
HIV Life Cycle (Homo sapiens)
Late Phase of HIV Life Cycle (Homo sapiens)
Transcription of the HIV genome (Homo sapiens)
Formation of HIV elongation complex in the absence of HIV Tat (Homo sapiens)
Recruitment of elongation factors to form HIV-1 elongation complex (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
HIV-1 elongation complex [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
HIV Transcription Elongation (Homo sapiens)
Tat-mediated elongation of the HIV-1 transcript (Homo sapiens)
Addition of nucleotides leads to HIV-1 transcript elongation (Homo sapiens)
HIV-1 Tat-containing processive elongation complex [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
HIV-1 elongation complex containing Tat [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
Formation of HIV-1 elongation complex containing HIV-1 Tat (Homo sapiens)
Recruitment of elongation factors to form HIV-1 elongation complex (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
HIV-1 elongation complex containing Tat [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
Pol II elongation complex moves on the HIV-1 template as transcript elongates (Homo sapiens)
HIV-1 Tat-containing processive elongation complex [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
Tat-containing elongation complex prior to separation [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
Separation of elongating HIV-1 transcript from template (Homo sapiens)
P-TEFb(Cyclin T1:Cdk9)-containing elongation complex with separated and uncleaved transcript [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
Tat-containing elongation complex prior to separation [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
HIV elongation arrest and recovery (Homo sapiens)
7-14 nt. Backtracking of Pol II complex on the HIV-1 template leading to elongation arrest (Homo sapiens)
HIV-1 arrested processive elongation complex [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
HIV-1 processive elongation complex [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
Abortive termination of HIV-1 elongation after arrest (Homo sapiens)
HIV-1 aborted elongation complex after arrest [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
HIV-1 arrested processive elongation complex [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
TFIIS-mediated recovery of HIV-1 elongation from arrest (Homo sapiens)
HIV-1 arrested processive elongation complex [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
HIV-1 processive elongation complex [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
Pausing and recovery of HIV elongation (Homo sapiens)
2-4 nt.backtracking of Pol II complex on the HIV-1 template leading to elongation pausing (Homo sapiens)
HIV-1 paused processive elongation complex [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
HIV-1 processive elongation complex [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
Resumption of elongation of HIV-1 transcript after recovery from pausing (Homo sapiens)
HIV-1 paused processive elongation complex [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
HIV-1 processive elongation complex [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
Pausing and recovery of Tat-mediated HIV elongation (Homo sapiens)
2-4 nt.backtracking of Pol II complex on the HIV-1 template leading to elongation pausing (Homo sapiens)
HIV-1 Tat-containing paused processive elongation complex [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
HIV-1 Tat-containing processive elongation complex [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
Resumption of elongation of HIV-1 transcript after recovery from pausing (Homo sapiens)
HIV-1 Tat-containing paused processive elongation complex [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
HIV-1 Tat-containing processive elongation complex [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
Tat-mediated HIV elongation arrest and recovery (Homo sapiens)
7-14 nt. Backtracking of Pol II complex on the HIV-1 template leading to elongation arrest (Homo sapiens)
HIV-1 Tat-containing arrested processive elongation complex [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
HIV-1 Tat-containing processive elongation complex [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
Abortive termination of HIV-1 elongation after arrest (Tat-containing elongation complex) (Homo sapiens)
HIV-1 Tat-containing aborted elongation complex after arrest [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
HIV-1 Tat-containing arrested processive elongation complex [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
TFIIS-mediated recovery of elongation from arrest (Homo sapiens)
HIV-1 Tat-containing arrested processive elongation complex [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
HIV-1 Tat-containing processive elongation complex [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Transcription of DNA Repair Genes (Homo sapiens)
CCNK:CDK12 binds RNA Pol II at DNA repair genes (Homo sapiens)
CCNK:CDK12:Elongation Complex at DNA Repair Genes [nucleoplasm] (Homo sapiens)
Elongation Complex at DNA Repair Genes [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
Elongation Complex at DNA Repair Genes [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Homo sapiens)
CCNK:CDK12:CDK12-Phosphorylated Elongation Complex at DNA repair genes [nucleoplasm] (Homo sapiens)
CDK12-Phosphorylated Elongation Complex [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
CCNK:CDK12:Elongation Complex at DNA Repair Genes [nucleoplasm] (Homo sapiens)
Elongation Complex at DNA Repair Genes [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
CDK12 stimulates expression of DNA repair genes (Homo sapiens)
CCNK:CDK12:CDK12-Phosphorylated Elongation Complex at DNA repair genes [nucleoplasm] (Homo sapiens)
CDK12-Phosphorylated Elongation Complex [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
RNA Polymerase II Pre-transcription Events (Homo sapiens)
2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Homo sapiens)
Paused processive elongation complex [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Homo sapiens)
Arrested processive elongation complex [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
Abortive termination of elongation after arrest (Homo sapiens)
Aborted elongation complex after arrest [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
Arrested processive elongation complex [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
Elongating transcript encounters a lesion in the template (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
Resumption of elongation after recovery from pausing (Homo sapiens)
Paused processive elongation complex [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
TFIIS-mediated recovery of elongation from arrest (Homo sapiens)
Arrested processive elongation complex [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
RNA Polymerase II Transcription Elongation (Homo sapiens)
Addition of nucleotides leads to transcript elongation (Homo sapiens)
Elongation complex [nucleoplasm] (Homo sapiens)
Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
Formation of RNA Pol II elongation complex (Homo sapiens)
Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
Recruitment of elongation factors to form elongation complex (Homo sapiens)
Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
Elongation complex [nucleoplasm] (Homo sapiens)
Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
Pol II elongation complex moves on the template as transcript elongates (Homo sapiens)
Elongation complex prior to separation [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
Separation of elongating transcript from template (Homo sapiens)
Elongation complex prior to separation [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
Elongation complex with separated and uncleaved transcript [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
RNA polymerase II transcribes snRNA genes (Homo sapiens)
CBCAP complex binds 7-methylguanosine cap of snRNA (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
LEC [nucleoplasm] (Homo sapiens)
ELL,ELL2,ELL3 [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
LEC [nucleoplasm] (Homo sapiens)
ELL,ELL2,ELL3 [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
Dephosphorylation and dissociation of RNA polymerase II at 3' end of snRNA gene (Homo sapiens)
LEC [nucleoplasm] (Homo sapiens)
ELL,ELL2,ELL3 [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
LEC [nucleoplasm] (Homo sapiens)
ELL,ELL2,ELL3 [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
Integrator complex processes the 3' end of snRNA (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
LEC [nucleoplasm] (Homo sapiens)
ELL,ELL2,ELL3 [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
LEC [nucleoplasm] (Homo sapiens)
ELL,ELL2,ELL3 [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
Pre-snRNA is elongated and capped with 7-methylguanosine (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
LEC [nucleoplasm] (Homo sapiens)
ELL,ELL2,ELL3 [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
LEC [nucleoplasm] (Homo sapiens)
ELL,ELL2,ELL3 [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
Pre-snRNA transcript initiation, Integrator binding, LEC binding (Homo sapiens)
LEC [nucleoplasm] (Homo sapiens)
ELL,ELL2,ELL3 [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
LEC [nucleoplasm] (Homo sapiens)
ELL,ELL2,ELL3 [nucleoplasm] (Homo sapiens)
ELL [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P55199 ELL
Gene Names
ELL, C19orf17
Chain
initiator methionine:1, chain:2-621
Reference Genes
BioGPS Gene:8178 ELL
COSMIC (genes):ELL ELL
CTD Gene:8178 ELL
dbSNP Gene:8178 ELL
ENSEMBL:ENSG00000105656.13 ELL
HGNC:23114 ELL
KEGG Gene (Homo sapiens):8178 ELL
Monarch:8178 ELL
NCBI Gene:8178 ELL
OMIM:600284 ELL
UCSC:P55199 ELL
Reference Transcript
RefSeq:NM_006532.3 ELL
Other Identifiers
0000450440
0006110403
11728333_a_at
11728334_a_at
11728335_a_at
1565254_PM_s_at
1565254_s_at
16870417
204095_PM_s_at
204095_s_at
204096_PM_s_at
204096_s_at
3855012
3855013
3855014
3855015
3855016
3855017
3855018
3855020
3855022
3855024
3855033
3855034
3855035
3855037
3855040
3855042
3855043
3855048
3855067
3855068
40044_at
62568_at
8035477
8178
A_23_P16537
A_23_P16538
A_23_P27936
A_33_P3406505
GE79578
GE83341
GO:0000791
GO:0000987
GO:0001701
GO:0003677
GO:0005515
GO:0005622
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0006366
GO:0006368
GO:0008023
GO:0015030
GO:0016073
GO:0016604
GO:0016607
GO:0019902
GO:0032786
GO:0032968
GO:0032991
GO:0035363
GO:0042795
GO:0042796
GO:0043226
GO:0045945
GO:0048856
HMNXSV003013072
Hs.5881.0.S1_3p_a_at
Hs2.406233.6.S1_3p_s_at
ILMN_1736048
PH_hs_0000595
PH_hs_0029774
TC19001290.hg
U16282_at
g12053058_3p_a_at
Participates
as an output of
Elongating transcript encounters a lesion in the template (Homo sapiens)
as a member of
ELL,ELL2,ELL3 [nucleoplasm] (Homo sapiens)
as a component of
HIV-1 Tat-containing aborted elongation complex after arrest [nucleoplasm] (Homo sapiens)
HIV-1 paused processive elongation complex [nucleoplasm] (Homo sapiens)
Aborted elongation complex after arrest [nucleoplasm] (Homo sapiens)
HIV-1 aborted elongation complex after arrest [nucleoplasm] (Homo sapiens)
HIV-1 arrested processive elongation complex [nucleoplasm] (Homo sapiens)
HIV-1 processive elongation complex [nucleoplasm] (Homo sapiens)
P-TEFb(Cyclin T1:Cdk9)-containing elongation complex with separated and uncleaved transcript [nucleoplasm] (Homo sapiens)
HIV-1 Tat-containing arrested processive elongation complex [nucleoplasm] (Homo sapiens)
HIV-1 Tat-containing paused processive elongation complex [nucleoplasm] (Homo sapiens)
Tat-containing elongation complex prior to separation [nucleoplasm] (Homo sapiens)
HIV-1 Tat-containing processive elongation complex [nucleoplasm] (Homo sapiens)
HIV-1 elongation complex containing Tat [nucleoplasm] (Homo sapiens)
Paused processive elongation complex [nucleoplasm] (Homo sapiens)
Arrested processive elongation complex [nucleoplasm] (Homo sapiens)
Elongation complex with separated and uncleaved transcript [nucleoplasm] (Homo sapiens)
Elongation complex prior to separation [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Homo sapiens)
HIV-1 elongation complex [nucleoplasm] (Homo sapiens)
CDK12-Phosphorylated Elongation Complex [nucleoplasm] (Homo sapiens)
Elongation Complex at DNA Repair Genes [nucleoplasm] (Homo sapiens)
as an input of
Recruitment of elongation factors to form HIV-1 elongation complex (Homo sapiens)
Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Homo sapiens)
Recruitment of elongation factors to form HIV-1 elongation complex (Homo sapiens)
This entity regulates
Positively
Recovery of RNA synthesis after TC-NER
(Homo sapiens)
Inferred To
Ell [nucleoplasm]
(Drosophila melanogaster)
Ell [nucleoplasm]
(Mus musculus)
Ell [nucleoplasm]
(Rattus norvegicus)
Ghost homologue of ELL [nucleoplasm]
(Dictyostelium discoideum)
Ghost homologue of ELL [nucleoplasm]
(Saccharomyces cerevisiae)
Ghost homologue of ELL [nucleoplasm]
(Schizosaccharomyces pombe)
ELL [nucleoplasm]
(Bos taurus)
ELL [nucleoplasm]
(Canis familiaris)
ELL [nucleoplasm]
(Danio rerio)
ELL [nucleoplasm]
(Gallus gallus)
ELL [nucleoplasm]
(Sus scrofa)
ell-1 [nucleoplasm]
(Caenorhabditis elegans)
ell [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
NP_006523.1
OpenTargets
ENSG00000105656
HPA
ENSG00000105656-ELL
GeneCards
P55199
Ensembl
ENST00000262809
,
ENSP00000262809
,
ENSG00000105656
PRO
P55199
Pharos - Targets
P55199
PDB
2DOA
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96H20 SNF8
1
SNF8 [cytosol]
(R-HSA-917711)
0.602
3
UniProt:P62136 PPP1CA
1
PPP1CA [cytosol]
(R-HSA-163525)
0.544
2
UniProt:Q9UHB7 AFF4
1
AFF4 [nucleoplasm]
(R-HSA-8932788)
0.527
2
UniProt:Q96JC9 EAF1
1
EAF1 [nucleoplasm]
(R-HSA-8932787)
0.527
2
UniProt:P0C1Z6 TFPT
1
TFPT [nucleoplasm]
(R-HSA-5689542)
0.488
2
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