Reactome | ACSL3 [endoplasmic reticulum membrane]

ACSL3 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-548787

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Long-chain-fatty-acid--CoA ligase 3

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O95573 ACSL3

Gene Names

ACSL3, ACS3, FACL3, LACS3

Chain

chain:1-720

Reference Genes

BioGPS Gene:2181 ACSL3

COSMIC (genes):ACSL3 ACSL3

CTD Gene:2181 ACSL3

dbSNP Gene:2181 ACSL3

ENSEMBL:ENSG00000123983.15 ACSL3

HGNC:3570 ACSL3

KEGG Gene (Homo sapiens):2181 ACSL3

Monarch:2181 ACSL3

NCBI Gene:2181 ACSL3

OMIM:602371 ACSL3

UCSC:O95573 ACSL3

Reference Transcript

Other Identifiers

0000360184

11739261_s_at

11743606_a_at

16891575

201660_PM_at

201660_at

201661_PM_s_at

201661_s_at

201662_PM_s_at

201662_s_at

2181

2529547

2529552

2529555

2529562

2529563

2529564

2529565

2529568

2529569

2529574

2529575

2529577

2529578

2529579

2529580

2529582

2529585

2529587

2529588

2529590

2529592

2529594

2529595

2529596

2529597

2529598

33880_at

33881_at

8048733

A_14_P113792

A_24_P248606

A_24_P37319

GE81398

GO:0000166

GO:0001676

GO:0004467

GO:0005515

GO:0005524

GO:0005622

GO:0005737

GO:0005739

GO:0005741

GO:0005777

GO:0005778

GO:0005783

GO:0005789

GO:0005794

GO:0005811

GO:0005886

GO:0006629

GO:0006631

GO:0006790

GO:0016020

GO:0016021

GO:0016192

GO:0016874

GO:0019901

GO:0019904

GO:0030154

GO:0030182

GO:0031956

GO:0034379

GO:0035336

GO:0035338

GO:0042998

GO:0043226

GO:0043231

GO:0044539

GO:0047676

GO:0048471

GO:0048856

GO:0051047

GO:0055086

GO:0065003

GO:0072659

GO:0090433

GO:0140657

GO:1901135

GO:2001247

HMNXSV003023160

Hs.268012.0.S3_3p_at

ILMN_1654414

ILMN_1666096

ILMN_2360705

PH_hs_0013723

TC02001350.hg

g12669907_3p_a_at

g4165017_3p_a_at

Participates

as a member of

ACSL1,3,5,6 [endoplasmic reticulum membrane] (Homo sapiens)

as a candidate of

ACSL3,4 [endoplasmic reticulum membrane] (Homo sapiens)

Other forms of this molecule

ACSL3 [mitochondrial outer membrane]

Inferred To

Acsl3 [endoplasmic reticulum membrane] (Mus musculus)

Acsl3 [endoplasmic reticulum membrane] (Rattus norvegicus)

Homologues of ACSL3 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

Homologues of ACSL3 [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

Homologues of ACSL3 [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)

acs-4 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

Acsl [endoplasmic reticulum membrane] (Drosophila melanogaster)

acs-17 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

ACSL3 [endoplasmic reticulum membrane] (Bos taurus)

ACSL3 [endoplasmic reticulum membrane] (Canis familiaris)

ACSL3 [endoplasmic reticulum membrane] (Danio rerio)

ACSL3 [endoplasmic reticulum membrane] (Gallus gallus)

ACSL3 [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

ACSL3 [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)

ACSL3 [endoplasmic reticulum membrane] (Sus scrofa)

ACSL3 [endoplasmic reticulum membrane] (Xenopus tropicalis)

Cross References

RefSeq

XP_016859073.1, NP_976251.1, NP_004448.2

OpenTargets

ENSG00000123983

IntEnz

6.2.1.15

GeneCards

O95573

HPA

ENSG00000123983-ACSL3

Ensembl

ENSP00000506361, ENSP00000505400, ENSP00000505654, ENST00000680395, ENSP00000504861, ENST00000680251, ENSP00000505940, ENSP00000505856, ENST00000680684, ENSP00000375918, ENST00000680147, ENST00000392066, ENSG00000123983, ENSP00000504907, ENSP00000350012, ENST00000357430, ENSP00000505793, ENST00000680921, ENST00000681383, ENST00000679514, ENST00000679558, ENST00000681697, ENSP00000506468

PRO

O95573

Pharos - Targets

O95573

HMDB Protein

HMDBP00647

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665656) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.527	2
UniProt:Q8NEZ3 WDR19	2	WDR19 [ciliary tip] (R-HSA-5625347) WDR19 [cilium] (R-HSA-5610446)	0.508	2
UniProt:Q96RY7 IFT140	2	IFT140 [ciliary tip] (R-HSA-5625345) IFT140 [cilium] (R-HSA-5610382)	0.508	2
UniProt:P05919 vpu	6	VPU (P05919) protein [extracellular region] (R-HIV-175522) VPU (P05919) protein [cytosol] (R-HIV-173223) VPU (P05919) protein [nucleoplasm] (R-HIV-175200) VPU (P05919) [endoplasmic reticulum membrane] (R-HIV-180550) VPU (P05919) [Golgi membrane] (R-HIV-3149439) VPU (P05919) [plasma membrane] (R-HIV-3149423)	0.462	2

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