ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA

Stable Identifier
R-HSA-548800
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
arachidonoyl-CoA + malonyl-CoA => 3-oxo-(7,10,13,16)-docosatetraenoyl-CoA + CO2 + CoASH
ReviewStatus
5/5
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Elongation of very long chain fatty acids proteins 1, 2, 3 and 5 (ELOVL1,2,3,5) catalyse the elongation of arachidonyl-CoA (AA-CoA) and malonyl-CoA (Mal-CoA) to form 3-oxo-(7,10,13,16)-docosatetraenoyl-CoA (3ODCT-CoA) (Leonard et al. 2002, Ohno et al. 2010).
Literature References
PubMed ID Title Journal Year
12371743 Identification and expression of mammalian long-chain PUFA elongation enzymes

Lewis, CJ, Huang, YS, Kopchick, JJ, Bobik, EG, Kelder, B, Chuang, LT, Mukerji, P, Leonard, AE

Lipids 2002
20937905 ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis

Suto, S, Sassa, T, Yamanaka, M, Igarashi, Y, Ohno, Y, Kihara, A, Mizutani, Y, Mitsutake, S

Proc Natl Acad Sci U S A 2010
Participants
Participates
Catalyst Activity

fatty acid elongase activity of ELOVL1,2,3,5 [endoplasmic reticulum membrane]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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