Reactome | ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA

ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA

Stable Identifier

R-HSA-548815

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

Synonyms

arachidoyl-CoA + malonyl-CoA => 3-oxobehenoyl-CoA + CO2 + CoASH [ELOVL7]

ReviewStatus

5/5

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ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA

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Elongation of very long chain fatty acids protein 7 (ELOVL7) catalyzes the reaction of arachidoyl-CoA (C20:0) and malonyl-CoA to form 3-oxobehenoyl-CoA, CO2, and CoASH. ELOVL7 is localized to the endoplasmic reticulum in transfected cells expressing the cloned cDNA (Tamura et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
19826053	Novel lipogenic enzyme ELOVL7 is involved in prostate cancer growth through saturated long-chain fatty acid metabolism Nakagawa, H, Miki, T, Nakamura, Y, Chung, S, Kobayashi, T, Fujioka, T, Ashida, S, Tamura, K, Furihata, M, Hullin-Matsuda, F, Shuin, T, Makino, A	Cancer Res	2009