Reactome | SNTB1 [plasma membrane]

SNTB1 [plasma membrane]

Stable Identifier

R-HSA-5490333

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Beta-1-syntrophin, SNTB1_HUMAN

Locations in the PathwayBrowser

Expand all

Extracellular matrix organization (Homo sapiens)

- Non-integrin membrane-ECM interactions (Homo sapiens)
  - Formation of the dystrophin-glycoprotein complex (DGC) (Homo sapiens)
    - DGC complex binds AGRN and HSPG2 (Homo sapiens)
      - DGC complex:laminins:F-actin [plasma membrane] (Homo sapiens)
        
        DGC complex:laminins [plasma membrane] (Homo sapiens)
        
        DGC [plasma membrane] (Homo sapiens)
        
        DTN:SNT complex [plasma membrane] (Homo sapiens)
        
        SNTA1,B1,B2,G2 [plasma membrane] (Homo sapiens)
        
        SNTB1 [plasma membrane] (Homo sapiens)
      - DGC complex:laminins:F-actin:AGRN,HSPG2 [plasma membrane] (Homo sapiens)
        
        DGC complex:laminins:F-actin [plasma membrane] (Homo sapiens)
        
        DGC complex:laminins [plasma membrane] (Homo sapiens)
        
        DGC [plasma membrane] (Homo sapiens)
        
        DTN:SNT complex [plasma membrane] (Homo sapiens)
        
        SNTA1,B1,B2,G2 [plasma membrane] (Homo sapiens)
        
        SNTB1 [plasma membrane] (Homo sapiens)
    - DGC complex binds laminins (Homo sapiens)
      - DGC [plasma membrane] (Homo sapiens)
        
        DTN:SNT complex [plasma membrane] (Homo sapiens)
        
        SNTA1,B1,B2,G2 [plasma membrane] (Homo sapiens)
        
        SNTB1 [plasma membrane] (Homo sapiens)
      - DGC complex:laminins [plasma membrane] (Homo sapiens)
        
        DGC [plasma membrane] (Homo sapiens)
        
        DTN:SNT complex [plasma membrane] (Homo sapiens)
        
        SNTA1,B1,B2,G2 [plasma membrane] (Homo sapiens)
        
        SNTB1 [plasma membrane] (Homo sapiens)
    - DGC:laminin complex binds F-actin (Homo sapiens)
      - DGC complex:laminins [plasma membrane] (Homo sapiens)
        
        DGC [plasma membrane] (Homo sapiens)
        
        DTN:SNT complex [plasma membrane] (Homo sapiens)
        
        SNTA1,B1,B2,G2 [plasma membrane] (Homo sapiens)
        
        SNTB1 [plasma membrane] (Homo sapiens)
      - DGC complex:laminins:F-actin [plasma membrane] (Homo sapiens)
        
        DGC complex:laminins [plasma membrane] (Homo sapiens)
        
        DGC [plasma membrane] (Homo sapiens)
        
        DTN:SNT complex [plasma membrane] (Homo sapiens)
        
        SNTA1,B1,B2,G2 [plasma membrane] (Homo sapiens)
        
        SNTB1 [plasma membrane] (Homo sapiens)
    - Recruitment of dystrophin, dystrobrevin and syntrophin proteins to the DGC (Homo sapiens)
      - DGC [plasma membrane] (Homo sapiens)
        
        DTN:SNT complex [plasma membrane] (Homo sapiens)
        
        SNTA1,B1,B2,G2 [plasma membrane] (Homo sapiens)
        
        SNTB1 [plasma membrane] (Homo sapiens)
      - DTN:SNT complex [plasma membrane] (Homo sapiens)
        
        SNTA1,B1,B2,G2 [plasma membrane] (Homo sapiens)
        
        SNTB1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13884 SNTB1

Gene Names

SNTB1, SNT2B1

Chain

initiator methionine:1, chain:2-538

Reference Genes

BioGPS Gene:6641 SNTB1

COSMIC (genes):SNTB1 SNTB1

CTD Gene:6641 SNTB1

dbSNP Gene:6641 SNTB1

ENSEMBL:ENSG00000172164 SNTB1

HGNC:11168 SNTB1

KEGG:hsa:6641 SNTB1

Monarch:6641 SNTB1

NCBI Gene:6641 SNTB1

OMIM:600026 SNTB1

UCSC:Q13884 SNTB1

Reference Transcript

Other Identifiers

11725221_a_at

11725222_a_at

11725223_at

11757964_s_at

17080630

208608_PM_s_at

208608_s_at

214708_PM_at

214708_at

215431_PM_at

215431_at

226438_3p_at

226438_PM_at

226438_at

3150845

3150846

3150847

3150848

3150851

3150852

3150854

3150859

3150860

3150861

3150862

3150864

3150881

3150882

3150899

3150911

3150941

3150942

3150943

3150944

3150945

3150946

3150947

3150948

3150950

3150951

3644013

37074_at

37075_at

44415_at

47319_at

64670_at

6641

69914_at

81358_at

8152606

A_23_P386030

A_23_P95029

GE79381

GO:0003012

GO:0003779

GO:0005198

GO:0005515

GO:0005516

GO:0005737

GO:0005856

GO:0005886

GO:0005925

GO:0006936

GO:0008092

GO:0012505

GO:0016010

GO:0016020

GO:0030165

GO:0032991

GO:0042383

GO:0045202

GO:0070161

HMNXSV003051582

HMNXSV003057761

Hs.44241.0.S1_3p_at

Hs.44241.0.S1_3p_s_at

Hs.44241.0.S1_3p_x_at

Hs.95011.1.S1_3p_at

ILMN_1793410

L31529_at

PH_hs_0025244

TC08001565.hg

g11321639_3p_a_at

Participates

as a member of

SNTA1,B1,B2,G2 [plasma membrane] (Homo sapiens)

Inferred To

stn-1 [plasma membrane] (Caenorhabditis elegans)

sntb1 [plasma membrane] (Danio rerio)

sntb1 [plasma membrane] (Xenopus tropicalis)

SNTB1 [plasma membrane] (Bos taurus)

SNTB1 [plasma membrane] (Canis familiaris)

SNTB1 [plasma membrane] (Gallus gallus)

SNTB1 [plasma membrane] (Sus scrofa)

Sntb1 [plasma membrane] (Mus musculus)

Sntb1 [plasma membrane] (Rattus norvegicus)

Syn1 [plasma membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_066301.1, XP_011515541.1

ENSEMBL

ENST00000395601, ENSG00000172164, ENSP00000431124, ENST00000517992, ENSP00000378965

OpenTargets

ENSG00000172164

GeneCards

SNTB1

HPA

ENSG00000172164-SNTB1

PRO

Q13884

Pharos - Targets

Q13884

GlyGen

Q13884

HMDB Protein

HMDBP01766

PDB

7PC4, 7P70

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P11532 DMD	1	DMD [cytosol] (R-HSA-390567)	0.839	7
UniProt:O95477 ABCA1	11	ABCA1 [plasma membrane] (R-HSA-194209) 4xPALM-C-p-2S-ABCA1 [plasma membrane] (R-HSA-5682069) 4xPALM-C-ABCA1 [endoplasmic reticulum membrane] (R-HSA-5682085) 4xPALM-C-ABCA1 [plasma membrane] (R-HSA-5682091) ABCA1 [endoplasmic reticulum membrane] (R-HSA-5682105) ABCA1 Q537R [plasma membrane] (R-HSA-5682199) ABCA1 R587W [plasma membrane] (R-HSA-5682197) ABCA1 S1446L [plasma membrane] (R-HSA-5682195) ABCA1 C1417R [plasma membrane] (R-HSA-5682190) ABCA1 N935S [plasma membrane] (R-HSA-5682200) ABCA1 W590S [plasma membrane] (R-HSA-5682201)	0.697	4
UniProt:Q9NS75 CYSLTR2	1	CYSLTR2 [plasma membrane] (R-HSA-416399)	0.623	2
UniProt:P53778 MAPK12	3	MAPK12 [cytosol] (R-HSA-171025) p-T183,Y185-MAPK12 [cytosol] (R-HSA-171021) MAPK12 [nucleoplasm] (R-HSA-448833)	0.623	2
UniProt:P60484 PTEN	20	K48polyUb-PTEN [cytosol] (R-HSA-8874327) PolyUb-PTEN [nucleoplasm] (R-HSA-6782515) PTEN H93R [cytosol] (R-HSA-2318524) PTEN C124R [cytosol] (R-HSA-2317439) PTEN H93Y [cytosol] (R-HSA-2318520) PTEN R130G [cytosol] (R-HSA-2317339) PTEN H93D [cytosol] (R-HSA-2318550) PTEN R130L [cytosol] (R-HSA-2317430) PTEN H93A [cytosol] (R-HSA-2318544) PTEN G129E [cytosol] (R-HSA-2318509) PTEN S170N [cytosol] (R-HSA-2318408) PTEN R173P [cytosol] (R-HSA-2317480) PTEN R130Q [cytosol] (R-HSA-2317416) PTEN H93Q [cytosol] (R-HSA-2318565) PTEN G129R [cytosol] (R-HSA-2318501) PTEN H123Y [cytosol] (R-HSA-2318469) PTEN S170R [cytosol] (R-HSA-2318437) PTEN R173C [cytosol] (R-HSA-2317478) PTEN R173H [cytosol] (R-HSA-2317473) PTEN C124S [cytosol] (R-HSA-2317379)	0.611	5
UniProt:Q15418 RPS6KA1	7	p-S221,T359,S363,S380,T573,S732-RPS6KA1 [nucleoplasm] (R-HSA-444292) p-T359,S363,S380.T573,S732-RPS6KA1 [cytosol] (R-HSA-9619993) p-S221,T459,S363,S380,T573,S732-RPS6KA1 [cytosol] (R-HSA-9619871) p-T359,S363,T573-RPS6KA1 [cytosol] (R-HSA-9619957) RPS6KA1 [cytosol] (R-HSA-444256) p-4S,T359,T573-RPS6KA1 [nucleoplasm] (R-HSA-199829) RPS6KA1 [nucleoplasm] (R-HSA-199860)	0.611	4
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279)	0.571	4
UniProt:P46939 UTRN	1	UTRN [cytosol] (R-HSA-5216039)	0.564	2

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