Reactome | SNTA1 [plasma membrane]

SNTA1 [plasma membrane]

Stable Identifier

R-HSA-5490334

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Alpha-1-syntrophin, SNTA1_HUMAN

Locations in the PathwayBrowser

Expand all

Extracellular matrix organization (Homo sapiens)

- Non-integrin membrane-ECM interactions (Homo sapiens)
  - Formation of the dystrophin-glycoprotein complex (DGC) (Homo sapiens)
    - DGC complex binds AGRN and HSPG2 (Homo sapiens)
      - DGC complex:laminins:F-actin [plasma membrane] (Homo sapiens)
        
        DGC complex:laminins [plasma membrane] (Homo sapiens)
        
        DGC [plasma membrane] (Homo sapiens)
        
        DTN:SNT complex [plasma membrane] (Homo sapiens)
        
        SNTA1,B1,B2,G2 [plasma membrane] (Homo sapiens)
        
        SNTA1 [plasma membrane] (Homo sapiens)
      - DGC complex:laminins:F-actin:AGRN,HSPG2 [plasma membrane] (Homo sapiens)
        
        DGC complex:laminins:F-actin [plasma membrane] (Homo sapiens)
        
        DGC complex:laminins [plasma membrane] (Homo sapiens)
        
        DGC [plasma membrane] (Homo sapiens)
        
        DTN:SNT complex [plasma membrane] (Homo sapiens)
        
        SNTA1,B1,B2,G2 [plasma membrane] (Homo sapiens)
        
        SNTA1 [plasma membrane] (Homo sapiens)
    - DGC complex binds laminins (Homo sapiens)
      - DGC [plasma membrane] (Homo sapiens)
        
        DTN:SNT complex [plasma membrane] (Homo sapiens)
        
        SNTA1,B1,B2,G2 [plasma membrane] (Homo sapiens)
        
        SNTA1 [plasma membrane] (Homo sapiens)
      - DGC complex:laminins [plasma membrane] (Homo sapiens)
        
        DGC [plasma membrane] (Homo sapiens)
        
        DTN:SNT complex [plasma membrane] (Homo sapiens)
        
        SNTA1,B1,B2,G2 [plasma membrane] (Homo sapiens)
        
        SNTA1 [plasma membrane] (Homo sapiens)
    - DGC:laminin complex binds F-actin (Homo sapiens)
      - DGC complex:laminins [plasma membrane] (Homo sapiens)
        
        DGC [plasma membrane] (Homo sapiens)
        
        DTN:SNT complex [plasma membrane] (Homo sapiens)
        
        SNTA1,B1,B2,G2 [plasma membrane] (Homo sapiens)
        
        SNTA1 [plasma membrane] (Homo sapiens)
      - DGC complex:laminins:F-actin [plasma membrane] (Homo sapiens)
        
        DGC complex:laminins [plasma membrane] (Homo sapiens)
        
        DGC [plasma membrane] (Homo sapiens)
        
        DTN:SNT complex [plasma membrane] (Homo sapiens)
        
        SNTA1,B1,B2,G2 [plasma membrane] (Homo sapiens)
        
        SNTA1 [plasma membrane] (Homo sapiens)
    - Recruitment of dystrophin, dystrobrevin and syntrophin proteins to the DGC (Homo sapiens)
      - DGC [plasma membrane] (Homo sapiens)
        
        DTN:SNT complex [plasma membrane] (Homo sapiens)
        
        SNTA1,B1,B2,G2 [plasma membrane] (Homo sapiens)
        
        SNTA1 [plasma membrane] (Homo sapiens)
      - DTN:SNT complex [plasma membrane] (Homo sapiens)
        
        SNTA1,B1,B2,G2 [plasma membrane] (Homo sapiens)
        
        SNTA1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13424 SNTA1

Gene Names

SNTA1, SNT1

Chain

chain:1-505

Reference Genes

BioGPS Gene:6640 SNTA1

COSMIC (genes):SNTA1 SNTA1

CTD Gene:6640 SNTA1

dbSNP Gene:6640 SNTA1

ENSEMBL:ENSG00000101400 SNTA1

HGNC:11167 SNTA1

KEGG:hsa:6640 SNTA1

Monarch:6640 SNTA1

NCBI Gene:6640 SNTA1

OMIM:601017 SNTA1

UCSC:Q13424 SNTA1

Reference Transcript

RefSeq:NM_003098.3 SNTA1

Other Identifiers

11717365_x_at

11752890_a_at

16918407

203516_PM_at

203516_at

35627_at

3903053

3903054

3903055

3903056

3903057

3903058

3903059

3903061

3903062

3903063

3903064

3903065

3903067

3903070

3903071

3903072

3903073

3903074

3903075

6640

74622_at

8065683

A_23_P57227

A_24_P322709

GE59140

GO:0002027

GO:0003012

GO:0003779

GO:0005198

GO:0005515

GO:0005516

GO:0005737

GO:0005856

GO:0005886

GO:0006936

GO:0008092

GO:0016010

GO:0016013

GO:0016020

GO:0016328

GO:0017080

GO:0030165

GO:0031594

GO:0032991

GO:0042383

GO:0044325

GO:0050998

GO:0051117

GO:0060307

GO:0070161

GO:0086005

GO:0098772

GO:1902305

HMNXSV003012459

ILMN_1753241

PH_hs_0002656

S81737_s_at

TC20000770.hg

U40571_at

g4507136_3p_at

Participates

as a member of

SNTA1,B1,B2,G2 [plasma membrane] (Homo sapiens)

Inferred To

stn-1 [plasma membrane] (Caenorhabditis elegans)

SNTA1 [plasma membrane] (Bos taurus)

SNTA1 [plasma membrane] (Canis familiaris)

SNTA1 [plasma membrane] (Gallus gallus)

Snta1 [plasma membrane] (Mus musculus)

Snta1 [plasma membrane] (Rattus norvegicus)

CDK5RAP1 [plasma membrane] (Sus scrofa)

snta1 [plasma membrane] (Xenopus tropicalis)

Syn1 [plasma membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_003089.1

ENSEMBL

ENST00000217381, ENSP00000217381, ENSG00000101400

OpenTargets

ENSG00000101400

GeneCards

SNTA1

HPA

ENSG00000101400-SNTA1

PRO

Q13424

Pharos - Targets

Q13424

Orphanet

SNTA1

HMDB Protein

HMDBP08001

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P11532 DMD	1	DMD [cytosol] (R-HSA-390567)	0.798	6
UniProt:O95477 ABCA1	11	ABCA1 [plasma membrane] (R-HSA-194209) 4xPALM-C-p-2S-ABCA1 [plasma membrane] (R-HSA-5682069) 4xPALM-C-ABCA1 [endoplasmic reticulum membrane] (R-HSA-5682085) 4xPALM-C-ABCA1 [plasma membrane] (R-HSA-5682091) ABCA1 [endoplasmic reticulum membrane] (R-HSA-5682105) ABCA1 Q537R [plasma membrane] (R-HSA-5682199) ABCA1 R587W [plasma membrane] (R-HSA-5682197) ABCA1 S1446L [plasma membrane] (R-HSA-5682195) ABCA1 C1417R [plasma membrane] (R-HSA-5682190) ABCA1 N935S [plasma membrane] (R-HSA-5682200) ABCA1 W590S [plasma membrane] (R-HSA-5682201)	0.656	3
UniProt:Q9NS75 CYSLTR2	1	CYSLTR2 [plasma membrane] (R-HSA-416399)	0.623	2
UniProt:P60484 PTEN	20	K48polyUb-PTEN [cytosol] (R-HSA-8874327) PolyUb-PTEN [nucleoplasm] (R-HSA-6782515) PTEN H93R [cytosol] (R-HSA-2318524) PTEN C124R [cytosol] (R-HSA-2317439) PTEN H93Y [cytosol] (R-HSA-2318520) PTEN R130G [cytosol] (R-HSA-2317339) PTEN H93D [cytosol] (R-HSA-2318550) PTEN R130L [cytosol] (R-HSA-2317430) PTEN H93A [cytosol] (R-HSA-2318544) PTEN G129E [cytosol] (R-HSA-2318509) PTEN S170N [cytosol] (R-HSA-2318408) PTEN R173P [cytosol] (R-HSA-2317480) PTEN R130Q [cytosol] (R-HSA-2317416) PTEN H93Q [cytosol] (R-HSA-2318565) PTEN G129R [cytosol] (R-HSA-2318501) PTEN H123Y [cytosol] (R-HSA-2318469) PTEN S170R [cytosol] (R-HSA-2318437) PTEN R173C [cytosol] (R-HSA-2317478) PTEN R173H [cytosol] (R-HSA-2317473) PTEN C124S [cytosol] (R-HSA-2317379)	0.611	4
UniProt:Q15418 RPS6KA1	7	p-S221,T359,S363,S380,T573,S732-RPS6KA1 [nucleoplasm] (R-HSA-444292) p-T359,S363,S380.T573,S732-RPS6KA1 [cytosol] (R-HSA-9619993) p-S221,T459,S363,S380,T573,S732-RPS6KA1 [cytosol] (R-HSA-9619871) p-T359,S363,T573-RPS6KA1 [cytosol] (R-HSA-9619957) RPS6KA1 [cytosol] (R-HSA-444256) p-4S,T359,T573-RPS6KA1 [nucleoplasm] (R-HSA-199829) RPS6KA1 [nucleoplasm] (R-HSA-199860)	0.611	4
UniProt:Q63538	3	Mapk12 [nucleoplasm] (R-RNO-448833) phospho-Mapk12 [cytosol] (R-RNO-171021) Mapk12 [cytosol] (R-RNO-171025)	0.602	5
UniProt:P46939 UTRN	1	UTRN [cytosol] (R-HSA-5216039)	0.527	2