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SLC22A5 [plasma membrane]
Stable Identifier
R-HSA-549319
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
OCTN2, Organic cation transporter 2, solute carrier family 22 (organic cation transporter), member 5, Solute carrier family 22 member 5, S22A5_HUMAN
Icon
Locations in the PathwayBrowser for interactor UniProt:Q01581 HMGCS1
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Fatty acid metabolism (Homo sapiens)
Carnitine metabolism (Homo sapiens)
OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol (Homo sapiens)
SLC22A5 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O76082 SLC22A5
Gene Names
SLC22A5, OCTN2
Chain
chain:1-557
Reference Genes
BioGPS Gene:6584 SLC22A5
COSMIC (genes):SLC22A5 SLC22A5
CTD Gene:6584 SLC22A5
dbSNP Gene:6584 SLC22A5
ENSEMBL:ENSG00000197375 SLC22A5
ENSEMBL_homo_sapiens_GENE:ENSG00000197375.14 SLC22A5
HGNC:10969 SLC22A5
KEGG Gene (Homo sapiens):6584 SLC22A5
Monarch:6584 SLC22A5
NCBI Gene:6584 SLC22A5
OMIM:603377 SLC22A5
UCSC:O76082 SLC22A5
Reference Transcript
RefSeq:NM_003060.3 SLC22A5
RefSeq:NM_001308122.1 SLC22A5
Other Identifiers
11740657_a_at
11740658_a_at
16989018
205074_PM_at
205074_at
2828521
2828522
2828523
2828531
2828532
2828534
2828536
2828537
2828540
2828543
2828546
2828548
2828549
2828550
2828551
2828552
2828553
2828554
32084_at
4039277
6584
8107920
A_24_P174755
GE54539
GO:0000166
GO:0002376
GO:0003013
GO:0005215
GO:0005515
GO:0005524
GO:0005576
GO:0005615
GO:0005737
GO:0005783
GO:0005829
GO:0005886
GO:0006811
GO:0006814
GO:0009609
GO:0009925
GO:0015199
GO:0015226
GO:0015293
GO:0015651
GO:0015697
GO:0015879
GO:0016020
GO:0016324
GO:0022600
GO:0022857
GO:0030165
GO:0031526
GO:0034341
GO:0034612
GO:0042908
GO:0042910
GO:0043226
GO:0055085
GO:0060731
GO:0070062
GO:0070715
GO:0098542
GO:0098754
GO:0150104
GO:1900749
GO:1901235
GO:1902270
GO:1902603
GO:1990961
HMNXSV003001628
HMNXSV003022058
ILMN_1699357
PH_hs_0001461
TC05000635.hg
g4507004_3p_at
g4507004_3p_x_at
Participates
as a member of
SLC22A4, 5,15,16 [plasma membrane] (Homo sapiens)
Other forms of this molecule
SLC22A5 W132* [plasma membrane]
SLC22A5 R169Q [plasma membrane]
SLC22A5 R169W [plasma membrane]
SLC22A5 R254* [plasma membrane]
SLC22A5 G15W [plasma membrane]
SLC22A5 P478L [plasma membrane]
Inferred To
Orct [plasma membrane]
(Drosophila melanogaster)
Dmel\CG16727 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG14855 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG4630 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG7342 [plasma membrane]
(Drosophila melanogaster)
pes-23 [plasma membrane]
(Caenorhabditis elegans)
Dmel\CG10486 [plasma membrane]
(Drosophila melanogaster)
slc22a5 [plasma membrane]
(Xenopus tropicalis)
Dmel\CG6356 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG5592 [plasma membrane]
(Drosophila melanogaster)
CG6596 [plasma membrane]
(Drosophila melanogaster)
CT19169 [plasma membrane]
(Drosophila melanogaster)
CarT [plasma membrane]
(Drosophila melanogaster)
slc22a21 [plasma membrane]
(Danio rerio)
oct-2 [plasma membrane]
(Caenorhabditis elegans)
suex-2 [plasma membrane]
(Caenorhabditis elegans)
CG31530-RA [plasma membrane]
(Drosophila melanogaster)
CG8654-RA [plasma membrane]
(Drosophila melanogaster)
Homologues of SLC22A5 [plasma membrane]
(Caenorhabditis elegans)
Homologues of SLC22A5 [plasma membrane]
(Danio rerio)
Homologues of SLC22A5 [plasma membrane]
(Drosophila melanogaster)
Homologues of SLC22A5 [plasma membrane]
(Xenopus tropicalis)
SLC22A5 [plasma membrane]
(Bos taurus)
SLC22A5 [plasma membrane]
(Caenorhabditis elegans)
SLC22A5 [plasma membrane]
(Canis familiaris)
SLC22A5 [plasma membrane]
(Gallus gallus)
SLC22A5 [plasma membrane]
(Mus musculus)
SLC22A5 [plasma membrane]
(Rattus norvegicus)
SLC22A5 [plasma membrane]
(Sus scrofa)
slc22a4 [plasma membrane]
(Danio rerio)
slc22a4 [plasma membrane]
(Xenopus tropicalis)
Dmel\CG17752 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG7333 [plasma membrane]
(Drosophila melanogaster)
Orct2 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG4465 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG14857 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG4462 [plasma membrane]
(Drosophila melanogaster)
oct-1 [plasma membrane]
(Caenorhabditis elegans)
Dmel\CG7084 [plasma membrane]
(Drosophila melanogaster)
Balat [plasma membrane]
(Drosophila melanogaster)
Dmel\CG14856 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG6231 [plasma membrane]
(Drosophila melanogaster)
SLC22A [plasma membrane]
(Drosophila melanogaster)
Dmel\CG17751 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG7458 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG4459 [plasma membrane]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001295051.1
,
NP_003051.1
Guide to Pharmacology - Targets
1023
OpenTargets
ENSG00000197375
HPA
ENSG00000197375-SLC22A5
GeneCards
O76082
Ensembl
ENSP00000402760
,
ENST00000245407
,
ENSP00000245407
,
ENST00000435065
,
ENSG00000197375
ZINC target
O76082
PRO
O76082
Pharos - Targets
O76082
Orphanet
15308
HMDB Protein
HMDBP01612
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q01581 HMGCS1
1
HMGCS1 [cytosol]
(R-HSA-191329)
0.564
2
UniProt:Q7Z3Y8 KRT27
1
KRT27 [cytosol]
(R-HSA-6809587)
0.556
3
UniProt:Q3LI67 KRTAP6-3
1
KRTAP6-3 [cytosol]
(R-HSA-6810281)
0.556
3
UniProt:Q5JR59-3 MTUS2
0.556
3
IntAct:EBI-22313194 CCSB ORF ID
0.556
3
UniProt:P0DPK4 NT2NC
0.556
3
UniProt:O76011 KRT34
1
KRT34 [cytosol]
(R-HSA-6809608)
0.556
3
UniProt:Q9GZM5 YIPF3
0.527
3
UniProt:Q8IVM8 S22A9
0.527
2
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