The CRYPTOCHROME-1 (CRY1) gene is transcribed to yield mRNA and the mRNA is translated to yield CRY1 protein (van der Spek et al. 1996, Thompson et al. 2003, also inferred from mouse homologs). CRY1 mRNA and protein show circadian expression. The promoter of the CRY1 gene contains an E-box which is bound by the BMAL1:CLOCK (ARNTL:CLOCK) heterodimer (and probably also the BMAL1:NPAS2 heterodimer), which activates transcription of CRY1.
The phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) heterodimer binds an E-box in the promoter of the CRY1 gene and activates transcription of CRY1. NPAS2 is predicted to act redundantly with CLOCK.
van der Spek, PJ, Bootsma, D, Yasui, A, Kobayashi, K, Eker, AP, Takao, M
Ebright, JN, Kelly, U, Bowes Rickman, C, Rickman, DW, Sancar, A, Thompson, CL, Shaw, SJ
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