Expression of PERIOD-2

Stable Identifier
R-HSA-549493
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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The PERIOD-2 (PER2) gene is transcribed to yield mRNA and the mRNA is translated to yield PER2 protein (Shearman et al. 1997, Nakamura et al. 2008, also inferred from mouse homologs). The promoter of the PER2 gene contains an E-box which binds the BMAL1:CLOCK (ARNTL:CLOCK) heterodimer (and probably also the BMAL1:NPAS2 (ARNTL:NPAS2) heterodimer). The BMAL1:CLOCK heterodimer activates transcription of PER2.

Literature References
PubMed ID Title Journal Year
9427249 Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei

Shearman, LP, Zylka, MJ, Weaver, DR, Kolakowski LF, Jr, Reppert, SM

Neuron 1997
18317514 Cryptochrome and Period Proteins Are Regulated by the CLOCK/BMAL1 Gene: Crosstalk between the PPARs/RXRalpha-Regulated and CLOCK/BMAL1-Regulated Systems

Nakamura, K, Inoue, I, Takahashi, S, Komoda, T, Katayama, S

PPAR Res 2008
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This event is regulated
Negatively by
Regulator
Summation

As inferred from mouse homologs, the NFIL3:BHLHE41 heterodimer (E4BP4:DEC2 heterodimer) binds E-box-like elements in the PER2 promoter and represses transcription of PER2 (Ohno et al. 2007, Tanoue et al. 2015).

Positively by
Regulator
Summation

As inferred from mouse, the phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) heterodimer binds a noncanonical E-box in the promoter of the PER2 gene and activates transcription of PER2. NPAS2 is predicted to act redundantly with CLOCK.

Regulator
Summation

As inferred from mouse, glucocorticoids bind the glucocorticoid receptor at the promoter of the PER2 gene and enhance rhythmic transcription.

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