Reactome | GNA12 [plasma membrane]

GNA12 [plasma membrane]

Stable Identifier

R-HSA-55355

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

G protein alpha 12, Guanine nucleotide-binding protein, alpha-12 subunit, G alpha 12

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Locations in the PathwayBrowser

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Hemostasis (Homo sapiens)

- Platelet activation, signaling and aggregation (Homo sapiens)
  - Thrombin signalling through proteinase activated receptors (PARs) (Homo sapiens)
    - Thrombin-activated PARs activate G12/13 (Homo sapiens)
      - Thrombin activated PAR:G12/13 (active) [plasma membrane] (Homo sapiens)
        
        G-protein G12/G13 (active) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein G12 (active) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (12):GTP [plasma membrane] (Homo sapiens)
        
        GNA12 [plasma membrane] (Homo sapiens)
      - Thrombin activated PAR:G12/13 (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein G12/G13 (inactive) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein G12 (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (12):GDP [plasma membrane] (Homo sapiens)
        
        GNA12 [plasma membrane] (Homo sapiens)
    - Thrombin-activated PARs binds G-protein G12/13 (Homo sapiens)
      - G-protein G12/G13 (inactive) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein G12 (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (12):GDP [plasma membrane] (Homo sapiens)
        
        GNA12 [plasma membrane] (Homo sapiens)
      - Thrombin activated PAR:G12/13 (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein G12/G13 (inactive) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein G12 (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (12):GDP [plasma membrane] (Homo sapiens)
        
        GNA12 [plasma membrane] (Homo sapiens)
    - Thrombin-activated PARs:G12/13 (active) dissociate (Homo sapiens)
      - G-protein alpha (12/13):GTP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (12):GTP [plasma membrane] (Homo sapiens)
        
        GNA12 [plasma membrane] (Homo sapiens)
      - Thrombin activated PAR:G12/13 (active) [plasma membrane] (Homo sapiens)
        
        G-protein G12/G13 (active) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein G12 (active) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (12):GTP [plasma membrane] (Homo sapiens)
        
        GNA12 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q03113 GNA12

Gene Names

GNA12

Chain

chain:1-381

Reference Genes

BioGPS Gene:2768 GNA12

COSMIC (genes):GNA12 GNA12

CTD Gene:2768 GNA12

dbSNP Gene:2768 GNA12

ENSEMBL:ENSG00000146535 GNA12

ENSEMBL_homo_sapiens_GENE:ENSG00000146535.14 GNA12

HGNC:4380 GNA12

KEGG Gene (Homo sapiens):2768 GNA12

Monarch:2768 GNA12

NCBI Gene:2768 GNA12

OMIM:604394 GNA12

UCSC:Q03113 GNA12

Reference Transcript

Other Identifiers

11727847_a_at

11727848_a_at

11751417_a_at

221737_PM_at

221737_at

224681_PM_at

224681_at

2768

3035915

3035916

3035917

3035918

3035919

3035920

3035921

3035922

3035945

3035951

3035952

3035963

3035964

3035965

3035966

34106_at

57079_at

8137865

919_at

A_23_P215265

A_23_P354270

A_24_P98086

GO:0000166

GO:0001664

GO:0001701

GO:0003013

GO:0003824

GO:0003924

GO:0005515

GO:0005525

GO:0005737

GO:0005834

GO:0005886

GO:0005925

GO:0007165

GO:0007186

GO:0007188

GO:0007266

GO:0007596

GO:0008217

GO:0008360

GO:0009410

GO:0010762

GO:0016020

GO:0016328

GO:0016787

GO:0019001

GO:0019888

GO:0023052

GO:0030154

GO:0030163

GO:0031526

GO:0031683

GO:0031752

GO:0032006

GO:0032434

GO:0032516

GO:0035556

GO:0036211

GO:0042060

GO:0042733

GO:0043005

GO:0043025

GO:0046872

GO:0048856

GO:0048870

GO:0051721

GO:0098772

GO:1904706

GO:1904753

HMNXSV003029799

Hs.182874.1.S2_3p_at

Hs.182874.1.S3_3p_at

ILMN_1692191

ILMN_1699358

ILMN_2216157

PH_hs_0010791

TC07001101.hg

TC07002755.hg

Participates

as a component of

Inferred To

gna12 [plasma membrane] (Danio rerio)

GNA12 [plasma membrane] (Bos taurus)

GNA12 [plasma membrane] (Caenorhabditis elegans)

GNA12 [plasma membrane] (Canis familiaris)

GNA12 [plasma membrane] (Drosophila melanogaster)

GNA12 [plasma membrane] (Gallus gallus)

GNA12 [plasma membrane] (Mus musculus)

GNA12 [plasma membrane] (Rattus norvegicus)

GNA12 [plasma membrane] (Sus scrofa)

GNAL [plasma membrane] (Dictyostelium discoideum)

GNAL [plasma membrane] (Saccharomyces cerevisiae)

GNAL [plasma membrane] (Schizosaccharomyces pombe)

gpa-17 [plasma membrane] (Caenorhabditis elegans)

Homologues of GNAL [plasma membrane] (Dictyostelium discoideum)

Homologues of GNA12 [plasma membrane] (Caenorhabditis elegans)

gbqA [plasma membrane] (Dictyostelium discoideum)

Cross References

RefSeq

NP_001269370.1, NP_031379.2, NP_001280021.1

OpenTargets

ENSG00000146535

HPA

ENSG00000146535-GNA12

GeneCards

Q03113

Ensembl

ENSG00000146535, ENST00000407904, ENSP00000385935, ENSP00000275364, ENST00000275364

PRO

Q03113

Pharos - Targets

Q03113

Orphanet

26399

HMDB Protein

HMDBP11484

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