Reactome | GNB1 [photoreceptor disc membrane]

GNB1 [photoreceptor disc membrane]

Stable Identifier

R-HSA-55373

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

photoreceptor disc membrane

Synonyms

Guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 1, Transducin beta chain 1

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External Reference Information

External Reference

UniProt:P62873 GNB1

Gene Names

GNB1

Chain

initiator methionine:, chain:2-340

Reference Genes

BioGPS Gene:2782 GNB1

COSMIC (genes):GNB1 GNB1

CTD Gene:2782 GNB1

dbSNP Gene:2782 GNB1

ENSEMBL:ENSG00000078369 GNB1

HGNC:4396 GNB1

KEGG:hsa:2782 GNB1

Monarch:2782 GNB1

NCBI Gene:2782 GNB1

OMIM:139380 GNB1

UCSC:P62873 GNB1

Reference Transcript

Participates

as a component of

GNB1:GNGT1 [photoreceptor disc membrane] (Homo sapiens)

Other forms of this molecule

GNB1 [cytosol]

GNB1 [plasma membrane]

Unfolded GNB1 [cytosol]

Partially folded GNB1 [cytosol]

Inferred To

gnb1b [photoreceptor disc membrane] (Danio rerio)

Gnb1 [photoreceptor disc membrane] (Bos taurus)

Gnb1 [photoreceptor disc membrane] (Mus musculus)

Gnb1 [photoreceptor disc membrane] (Rattus norvegicus)

GNB1 [photoreceptor disc membrane] (Canis familiaris)

GNB1 [photoreceptor disc membrane] (Sus scrofa)

gnb1 [photoreceptor disc membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001269468.1, XP_054192031.1, XP_047274023.1, XP_047274027.1, XP_054192052.1, XP_054192046.1, XP_047274006.1, XP_047274002.1, XP_054192043.1, XP_054192047.1, XP_054192045.1, XP_047274026.1, XP_054192041.1, XP_054192035.1, XP_054192033.1, XP_047273998.1, XP_054192054.1, XP_047274014.1, XP_016856549.1, XP_054192056.1, NP_001269467.1, XP_054192032.1, XP_054192034.1, XP_024302263.1, XP_054192049.1, XP_047274024.1, XP_054192030.1, XP_054192051.1, XP_047274019.1, XP_047274013.1, NP_002065.1, XP_054192038.1, XP_047274010.1, XP_047273999.1, XP_054192044.1, XP_054192048.1, XP_047274025.1, XP_054192050.1, XP_054192037.1, XP_047274001.1, XP_047274005.1, XP_047274012.1, XP_047274016.1, XP_054192039.1, XP_047274018.1, XP_047274011.1, XP_047274015.1, XP_016856550.1, XP_054192053.1, XP_016856548.1, XP_054192042.1, XP_047274000.1, XP_047274017.1, XP_054192055.1, XP_054192036.1, XP_054192040.1

OpenTargets

ENSG00000078369

ENSEMBL

ENSP00000515438, ENSP00000481878, ENSP00000515440, ENSP00000515442, ENST00000703710, ENST00000703699, ENST00000703697, ENSP00000515444, ENST00000703711, ENSP00000515443, ENST00000703693, ENSP00000515445, ENST00000703696, ENST00000703694, ENST00000703708, ENSP00000515427, ENSP00000515428, ENST00000703706, ENSG00000078369, ENST00000703692, ENSP00000515429, ENST00000703709, ENST00000703703, ENST00000703701, ENSP00000367872, ENST00000703704, ENST00000703702, ENSP00000515431, ENST00000378609, ENST00000703700, ENSP00000515432, ENSP00000515433, ENST00000610897, ENSP00000515434, ENSP00000515435, ENSP00000515437, ENSP00000515436

GeneCards

GNB1

HPA

ENSG00000078369-GNB1

PRO

P62873

Pharos - Targets

P62873

GlyGen

P62873

Orphanet

GNB1

HMDB Protein

HMDBP08398

PDB

8F2A, 7RTB, 8GUT, 8UXV, 8WSS, 8HS3, 7WUI, 8H4K, 8UNX, 7W2Z, 8XQS, 8DPG, 7EJX, 8IA8, 7VUJ, 7W0M, 8WWK, 7F4F, 8PM2, 7C2E, 8GEC, 7RKF, 7T9N, 7EO2, 7XKE, 7TYL, 7RG9, 7RBT, 8WGB, 8JHY, 7WY5, 9BQJ, 7XTA, 7YFD, 7XP4, 8W8A, 8I97, 8ID9, 6E3Y, 8K8J, 7XOW, 7EUO, 6XBK, 7LD4, 8ZRK, 8X3L, 7EZK, 7WV9, 8JXV, 8VY9, 7EW4, 7F6H, 8XIP, 8DWH, 7S1M, 7JVQ, 8EJK, 8XJK, 8J20, 8HCQ, 8IW7, 8TB0, 8G94, 6OSA, 8GDB, 8WC3, 8HJ5, 8J6L, 8UO3, 7W0O, 8WWI, 8GEE, 7WVU, 7CX2, 7P00, 7YON, 7YDJ, 6NI3, 8UH3, 7TYN, 7WY0, 7L0R, 6X19, 7XOU, 8U84, 9IVG, 8UGY, 6LFO, 7NA7, 8DZS, 8GE4, 8INR, 7TMW, 7RKM, 8K6M, 6OIJ, 8GFV, 7XBX, 7L1U, 7RAN, 8JLP, 8IKG, 8XQO, 8YW4, 8YY8, 9JKQ, 6PB0, 8YN3, 8EJC, 5UKL, 7VV3, 8GGF, 8J22, 8XJO, 9ERX, 8DPI, 8IW9, 8IOD, 7WKD, 8GUQ, 8E9X, 8IU2, 7WVX, 8WWL, 7F58, 8YKY, 7XK8, 7X5H, 7T10, 7W56, 8GDA, 7Y3G, 7X10, 8GEA, 7CKX, 6X18, 8SZG, 7T2G, 8K3Z, 7XT9, 8U4N, 7SBF, 8KFY, 8EMW, 7XP5, 6LI3, 7NA8, 8UNN, 8T3S, 7JOZ, 8FN0, 8K4N, 7RKN, 8SAI, 8JHB, 8U02, 8IJB, 7F1S, 8IUK, 8JLR, 7WU9, 8IKH, 8IY9, 8ZX5, 7EVY, 6VN7, 8GGC, 8SL3, 7VV5, 8T3O, 7F8V, 7YDH, 8JPP, 8HQN, 6B3J, 7KH0, 7E33, 8H4L, 7WVV, 8WCB, 7S3I, 8UNQ, 7XZ6, 7XW6, 8WC4, 8XIR, 8HJ2, 7XV3, 8GEJ, 8JIM, 9K1C, 7F4D, 7CKZ, 7TYF, 8I9A, 8FLU, 7WXW, 7TRK, 8U4P, 7F24, 9IQT, 7RMG, 8KGG, 8HQC, 8WP1, 8JSP, 8H2G, 6XBM, 7RGP, 8IJA, 6UUS, 8W8Q, 8GDZ, 8GG1, 8YIC, 5HE2, 7WF7, 8XJL, 7VDL, 8IRU, 7UTZ, 8U4O, 7Y64, 8HDO, 7F23, 8FLQ, 8F0J, 8YN9, 8XGO, 7XTB, 8KGK, 7VL9, 8IZB, 8GHV, 5HE0, 7WJ5, 8GG0, 8WJX, 7XMR, 6M1I, 7E2Y, 7VDH, 7SF8, 7YDM, 7T8X, 8XXU, 8H0P, 7X2D, 8G2Y, 6WI9, 8XOG, 6P9X, 8WRB, 8TYW, 7E9H, 7VIG, 8YN5, 7YK6, 8UNS, 7SR8, 8JZ7, 7LLY, 7YDP, 8FX5, 7TRQ, 8JHN, 8J1A, 7Y27, 8PKM, 7TYH, 8WC8, 8UO1, 6VMS, 8ZFJ, 7RMH, 6UUN, 7V68, 8IJD, 8XGS, 8J6J, 6WPW, 8IUM, 7XTC, 7EJA, 7K7Z, 7VKT, 8ZJE, 8U8F, 7F9Z, 8ZSJ, 8JZZ, 7SRR, 8E9Z, 7W55, 8UNZ, 7Y65, 8K4O, 8HTI, 8XOF, 8HJ0, 8JXT, 8YN7, 9IJ9, 7YP7, 8GEF, 8YUV, 5UKM, 7RKX, 8GFW, 7XTQ, 8U7Z, 8JD6, 8E3Z, 8WCA, 7CFN, 5UZ7, 8JLK, 9ASB, 9GYO, 8W89, 7K7L, 8X7A, 7SF7, 8GE6, 7WU3, 8HNK, 8XZF, 7EJ8, 7E2Z, 8IYH, 7TYY, 8IC0, 7VUY, 7EZM, 8GE3, 8IQ6, 7YAC, 8YW3, 9BKJ, 8ZSV, 8SZI, 8X2K, 9EW2, 7CFM, 8U82, 8GUS, 8UNO, 7L0S, 8IW4, 7VUG, 8JD5, 7BB6, 8IBU, 7WCM, 8I2G, 8YNA, 8J6Q, 8F0K, 8FY8, 7D7M, 7WYB, 8IA7, 7F55, 8ZPS, 8X79, 9DQH, 7Y1F, 6EG8, 8ITF, 8XZH, 8HNL, 9AVG, 7T96, 8YN2, 7RA3, 8DWG, 7S8L, 8HDP, 4PNK, 7Y67, 7JV5, 8GE2, 8JGG, 8XOJ, 7CMU, 8JEI, 8GG5, 8ZQE, 7VIE, 8W88, 7EW2, 7VGX, 7D77, 9AST, 8Y53, 6DDF, 6GDG, 8J24, 8X8N, 8K9K, 8DZQ, 8ID8, 8W8B, 7U2K, 7W7E, 8HBD, 7F1Q, 6N4B, 7LD3, 8GG4, 8K6O, 8ZJD, 8JXW, 7EW1, 8XIO, 8XYD, 7UM7, 8J21, 8UXY, 8JKB, 8XJM, 8GGE, 8IRS, 7X9A, 6XOX, 8UNW, 8WPU, 7W0L, 7LLL, 8GD9, 8J6R, 7XKF, 8WWJ, 7XA3, 7VUI, 8GEB, 7F4I, 8K2X, 7YAE, 7T9I, 7CX3, 7YOO, 8FYT, 8SMV, 7EO4, 7WXU, 8KFX, 7XP6, 8I9L, 7XXH, 6LFM, 8U83, 8I95, 6LML, 7TYO, 8ID4, 8DZR, 7Y66, 8GE5, 8F76, 7XJJ, 8GG7, 6KPG, 8J18, 8JXX, 7W53, 8XQN, 7LCI, 7EW3, 8ZX4, 8THK, 7JVR, 8IRV, 6OS9, 7UM5, 8J23, 7E32, 7W3Z, 8XJN, 6VCB, 8IZ4, 8UY0, 8F2B, 7VUH, 8IED, 8FU6, 7W0N, 7V6A, 8DPF, 8HSC, 8UNR, 8WWH, 7F0T, 8GED, 6M8S, 9IIX, 7P02, 7CX4, 8UHB, 9AUC, 8FLS, 7L0Q, 8VHF, 8KFZ, 8DDW, 6WHC, 8FMZ, 7XY7, 8JHI, 7F1O, 8T3V, 7DB6, 8GE1, 8ID3, 7XXI, 8GG6, 8J6D, 6XBL, 7TZF, 7W6P, 7T6B, 7XBW, 6PT0, 8HOC, 7SCG, 6KPF, 8W8R, 8J19, 8XVH, 8HVI, 6DDE, 7X2F, 8IW1, 8GGA, 8YN4, 5UKK, 8JPN, 8IJ3, 8HQM, 8E9Y, 6P9Y, 7X9C, 7WVY, 8WWN, 8JGB, 7XW5, 8UO2, 7T11, 8XIQ, 8WC5, 8HN8, 7CKW, 7S8M, 8JIL, 9K1D, 8PJK, 8WOG, 8FLR, 7XT8, 7YFC, 8UQO, 8HPT, 7RYC, 8ZSP, 8G05, 8K4P, 8UNM, 7XMS, 8IOC, 8ID6, 8HCX, 8WW2, 8J6I, 7XY6, 6XBJ, 8GY7, 8FN1, 7L1V, 7F1R, 7DFL, 7WU5, 8XVE, 5HE3, 7XJL, 6PB1, 8GGB, 8IRR, 8WST, 8U26, 7QVM, 7WVW, 8WWM, 7WZ4, 8UNT, 8DPH, 8WC7, 6G79, 7CKY, 7S8O, 8UWL, 7F4H, 8ZR5, 8WC9, 7T2H, 8KH5, 7JHJ, 7CRH, 7WY8, 8GG9, 8HMV, 6X1A, 8JSO, 7T94, 8XXV, 7S8P, 8HQE, 6OIK, 7WU4, 7WUQ, 8UO4, 6ORV, 7XK2, 8EIT, 7XZ5, 8WC6, 8YN6, 7EW0, 7YK7, 7YS6, 7Y89, 8JII, 8GFX, 8FLT, 8HIX, 8ZSS, 8X8L, 7W40, 8EMX, 8TZQ, 8U4Q, 7TYI, 7XMT, 8JT6, 7EPT, 8VY7, 8YW5, 7RMI, 7X9B, 8DZP, 8G59, 8IUL, 8XGU, 7XOV, 7X9Y, 8GE7, 8V6U, 8DDX, 8KH4, 8U1U, 8JLO, 8GG3, 8GCP, 7XBD, 7EVZ, 8JLZ, 6M1H, 7E2X, 8XWP, 8E9W, 7TYW, 7VUZ, 7X2C, 8K4S, 8IYS, 7EZH, 8XOH, 7W57, 7T90, 8YN8, 8IKL, 9EPQ, 8JER, 7VIF, 8GEG, 7F54, 8YUU, 8XVI, 8GG8, 6NIY, 8SG1, 7RKY, 7TRS, 8HJ1, 7X2V, 7TRP, 8XQP, 7Y24, 6D9H, 6WHA, 8UNP, 7BB7, 8GAG, 7E9G, 8Y45, 7V69, 6WZG, 8POK, 6LMK, 9AYF, 8GG2, 7VL8, 8GCM, 7U2L, 7WU2, 8XZG, 7F8W, 7F9Y, 8T3Q, 8YRG, 8XWQ, 7W0P, 8IYW, 9IVM, 8DWC, 8UNY, 7VFX, 8IQ4, 9EPP, 8THL, 8J9N, 8JGF, 4KFM, 7VIH, 8UYQ, 7F53, 8GEI, 7XKD, 8GFZ, 7UM6, 8GDC, 8RQL, 8UO0, 8U81, 8E3Y, 7F1Z, 7WCN, 8E3X, 8IBV, 8K6N, 8XQT, 6OT0, 8JLJ, 8UNV, 7WZ7, 8IEC, 8ZPT, 7VLA, 8FYL, 8I9S, 8JLQ, 7KI1, 8GE9, 7EJ0, 8HNM, 8HMP, 8XZI, 7VDM, 8H8J, 8JEF, 7MTS, 8JJP, 8H0Q, 8XQL, 7S8N, 7TYX, 8FYE, 5HE1, 8XGM, 8H4I, 8XOI, 7CMV, 7EB2, 7EW7, 7AUE, 9IYB, 7EXD, 8IRT, 7JVP, 8YUT, 9BKK, 8GEH, 7F6I, 7D76, 8W87, 8FEG, 8XQR, 8SZH, 7F6G, 8IA2, 8GFY, 6CRK, 8K9L, 8JD3, 8I7W, 8I7V, 7YKD, 9AXF, 8UNL, 8GUR, 7Y26, 8JR9, 8Y52, 7WUJ, 8UNU, 7TUZ, 6UVA, 8J6P, 8QJ2, 7KI0, 6OMM, 8FYX, 8GE8, 7EJK, 9DQJ, 8JLN, 7XJK, 7L0P, 8XZJ

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	10
UniProt:Q13371 PDCL	2	PDCL [cytosol] (R-HSA-6813727) p-S18,S19,S20,S25-PDCL [cytosol] (R-HSA-6814228)	0.643	4
UniProt:P63211 GNGT1	3	S-farn-GNGT1 [photoreceptor disc membrane] (R-HSA-2530520) GNGT1 [photoreceptor disc membrane] (R-HSA-55393) GNGT1 [plasma membrane] (R-HSA-167428)	0.621	3
UniProt:P07237 P4HB	3	P4HB [endoplasmic reticulum lumen] (R-HSA-174692) p-P4HB [endoplasmic reticulum lumen] (R-HSA-8956902) HC53,56-P4HB [endoplasmic reticulum lumen] (R-HSA-3341287)	0.556	3
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	4
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.527	10
UniProt:P10824 Gnai1	1	Guanine nucleotide-binding protein G(i), alpha-1 subunit [plasma membrane] (R-RNO-421889)	0.488	2

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