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MED22 [nucleoplasm]
Stable Identifier
R-HSA-556779
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Mediator of RNA polymerase II transcription subunit 22, MED22_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Transcriptional regulation of white adipocyte differentiation (Homo sapiens)
Expression of ANGPTL4 (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED22 [nucleoplasm] (Homo sapiens)
Expression of Adiponectin (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED22 [nucleoplasm] (Homo sapiens)
Expression of CD36 (platelet glycoprotein IV, FAT) (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED22 [nucleoplasm] (Homo sapiens)
Expression of CEBPA (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED22 [nucleoplasm] (Homo sapiens)
Expression of FABP4 (aP2) (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED22 [nucleoplasm] (Homo sapiens)
Expression of Leptin (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED22 [nucleoplasm] (Homo sapiens)
Expression of Lipoprotein lipase (LPL) (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED22 [nucleoplasm] (Homo sapiens)
Expression of Perilipin (PLIN) (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED22 [nucleoplasm] (Homo sapiens)
Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C) (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED22 [nucleoplasm] (Homo sapiens)
PPARG:RXRA heterodimer binds to fatty acid-like ligands (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED22 [nucleoplasm] (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED22 [nucleoplasm] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Regulation of lipid metabolism by PPARalpha (Homo sapiens)
PPARA activates gene expression (Homo sapiens)
Expression of ANGPTL4 (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED22 [nucleoplasm] (Homo sapiens)
Expression of CD36 (platelet glycoprotein IV, FAT) (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED22 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15528 MED22
Gene Names
MED22, SURF5
Chain
chain:1-200
Reference Genes
BioGPS Gene:6837 MED22
COSMIC (genes):MED22 MED22
CTD Gene:6837 MED22
dbSNP Gene:6837 MED22
ENSEMBL:ENSG00000148297 MED22
ENSEMBL:ENSG00000148297.16 MED22
ENSEMBL:ENSG00000281022.3 MED22
HGNC:11477 MED22
KEGG Gene (Homo sapiens):6837 MED22
Monarch:6837 MED22
NCBI Gene:6837 MED22
OMIM:185641 MED22
UCSC:Q15528 MED22
Reference Transcript
RefSeq:NM_181491.2 MED22
RefSeq:NM_133640.4 MED22
Other Identifiers
0000670152
0001410687
11755048_a_at
17099482
17099484
206593_PM_s_at
206593_s_at
3228631
3228632
3228634
3228636
3228637
3228638
3228639
3228640
3228641
3228642
3228643
3228644
3228645
3228646
37410_at
4051922
4051923
4051925
4051927
4051928
4051929
4051930
4051931
4051932
4051933
4051934
4051935
4051936
4051937
4051938
4051939
4052084
4052085
4052086
63978_s_at
6837
8164870
8164872
A_23_P501790
A_23_P501795
A_24_P55719
A_33_P3350227
GE58420
GO:0003712
GO:0005515
GO:0005622
GO:0005634
GO:0005737
GO:0006351
GO:0006354
GO:0006355
GO:0006357
GO:0016592
GO:0032968
GO:0032991
GO:0043226
GO:0051123
GO:0060261
GO:0065003
GO:0070847
HMNXSV003001437
ILMN_1697218
ILMN_1792860
PH_hs_0004519
PH_hs_0030480
TC09001685.hg
TC09001686.hg
X85178_at
g5803182_3p_a_at
Participates
as a component of
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
Cross References
RefSeq
NP_598395.1
,
NP_852468.1
OpenTargets
ENSG00000148297
GeneCards
Q15528
HPA
ENSG00000148297-MED22
Ensembl
ENST00000610888
,
ENST00000614493
,
ENST00000343730
,
ENST00000610672
,
ENST00000626118
,
ENST00000629975
,
ENSP00000478773
,
ENST00000631196
,
ENSP00000342343
,
ENSP00000487580
,
ENSG00000281022
,
ENSP00000485880
,
ENSP00000481493
,
ENSP00000486722
,
ENSG00000148297
,
ENST00000629522
,
ENSP00000482438
,
ENSP00000485715
PRO
Q15528
Pharos - Targets
Q15528
PDB
7ENA
,
7ENJ
,
7LBM
,
7ENC
,
7EMF
,
7NVR
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9BTT4 MED10
1
MED10 [nucleoplasm]
(R-HSA-212410)
0.825
6
UniProt:Q9NVC6 MED17
1
MED17 [nucleoplasm]
(R-HSA-212401)
0.688
4
UniProt:Q6P2C8 MED27
1
MED27 [nucleoplasm]
(R-HSA-556761)
0.589
3
UniProt:P49336 CDK8
1
CDK8 [nucleoplasm]
(R-HSA-212440)
0.569
5
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