Mediator Complex (consensus) [nucleoplasm]

Stable Identifier
R-HSA-556786
Type
Complex
Species
Homo sapiens
Compartment
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General

The Mediator Complex bridges transcription factors and the basal RNA polymerase II complex. Multiple analyses of immunoprecipitated complexes from human cells (HeLa cells) detects 31 subunits. Other complexes with fewer subunits may also exist.

Literature References
PubMed ID Title Journal Year
17138671 Quantitative proteomic analysis of distinct mammalian Mediator complexes using normalized spectral abundance factors

Zhu, D, Florens, LA, Conaway, RC, Paoletti, AC, Sato, S, Parmely, TJ, Conaway, JW, Washburn, MP, Tomomori-Sato, C

Proc. Natl. Acad. Sci. U.S.A. 2006
24882805 Subunit architecture and functional modular rearrangements of the transcriptional mediator complex

Tsai, KL, Conaway, RC, Conaway, JW, Asturias, FJ, Sato, S, Tomomori-Sato, C

Cell 2014
15175163 A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology

Washburn, MP, Swanson, SK, Tomomori-Sato, C, Jin, J, Sato, S, Florens, LA, Conaway, JW, Banks, CA, Parmely, TJ, Conaway, RC, Cai, Y, Zybailov, B

Mol Cell 2004
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