Reactome | MED13L [nucleoplasm]

MED13L [nucleoplasm]

Stable Identifier

R-HSA-556797

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Mediator of RNA polymerase II transcription subunit 13-like, MD13L_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Respiratory Syncytial Virus Infection Pathway (Homo sapiens)
      - RSV-host interactions (Homo sapiens)
        
        NS1 (1C) binds to Mediator complex (Homo sapiens)
        
        Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
        
        MED13L [nucleoplasm] (Homo sapiens)
        
        Mediator:NS1 [nucleoplasm] (Homo sapiens)
        
        Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
        
        MED13L [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q71F56 MED13L

Gene Names

MED13L, KIAA1025, PROSIT240, THRAP2, TRAP240L

Chain

chain:1-2210

Reference Genes

BioGPS Gene:23389 MED13L

COSMIC (genes):MED13L MED13L

CTD Gene:23389 MED13L

dbSNP Gene:23389 MED13L

ENSEMBL:ENSG00000123066 MED13L

HGNC:22962 MED13L

KEGG:hsa:23389 MED13L

Monarch:23389 MED13L

NCBI Gene:23389 MED13L

OMIM:608771 MED13L

UCSC:Q71F56 MED13L

Reference Transcript

RefSeq:NM_015335.4 MED13L

Other Identifiers

11724814_s_at

11724815_at

16770733

212207_PM_at

212207_at

212208_PM_at

212208_at

212209_PM_at

212209_at

216109_3p_at

216109_PM_at

216109_at

23389

242911_PM_at

242911_at

3473089

3473090

3473091

3473092

3473093

3473094

3473095

3473096

3473098

3473099

3473100

3473101

3473102

3473103

3473104

3473105

3473106

3473107

3473108

3473109

3473110

3473111

3473112

3473113

3473114

3473115

3473116

3473117

3473118

3473119

3473120

3473121

3473122

3473123

3473124

3473126

3473127

3473128

3473129

3473130

3473131

3473132

3473133

3473134

3473135

3473136

3473137

3473138

3473139

3473140

3473141

3473142

3473143

3473144

3473145

3473146

3473147

3473149

3473150

3473152

3473153

3473154

3473155

3473156

3473177

3473180

3473181

3473182

3473226

3473232

3473233

3473240

3473241

34785_at

51317_at

65216_at

77642_at

77643_f_at

7966706

A_23_P47991

A_24_P911508

GE56582

GE696371

GO:0003712

GO:0005634

GO:0005654

GO:0006355

GO:0006357

GO:0016592

GO:0043226

GO:0060090

GO:0140110

HMNXSV003023837

Hs.300949.0.A1_3p_at

Hs.306803.0.S1_3p_x_at

Hs.4084.0.S1_3p_at

Hs.4084.0.S2_3p_at

Hs.4084.0.S3_3p_at

Hs.4084.0.S3_3p_x_at

ILMN_1683959

PH_hs_0025393

TC12002004.hg

Participates

as a component of

Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_056150.1

ENSEMBL

ENST00000281928, ENSP00000281928

OpenTargets

ENSG00000123066

HPA

ENSG00000123066-MED13L

PRO

Q71F56

Pharos - Targets

Q71F56

Orphanet

MED13L

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P49336 CDK8	1	CDK8 [nucleoplasm] (R-HSA-212440)	0.802	9
UniProt:Q9BTT4 MED10	1	MED10 [nucleoplasm] (R-HSA-212410)	0.725	5
UniProt:Q9NPJ6 MED4	1	MED4 [nucleoplasm] (R-HSA-350263)	0.706	7
UniProt:Q15648 MED1	1	MED1 [nucleoplasm] (R-HSA-212445)	0.643	5
UniProt:O43513 MED7	1	MED7 [nucleoplasm] (R-HSA-212430)	0.643	4
UniProt:Q9Y3C7 MED31	1	MED31 [nucleoplasm] (R-HSA-212429)	0.643	3
UniProt:Q9NVC6 MED17	1	MED17 [nucleoplasm] (R-HSA-212401)	0.527	3
UniProt:Q93074 MED12	1	MED12 [nucleoplasm] (R-HSA-212343)	0.527	2
UniProt:O95402 MED26	1	MED26 [nucleoplasm] (R-HSA-556783)	0.527	4
UniProt:O60244 MED14	1	MED14 [nucleoplasm] (R-HSA-212441)	0.527	3
UniProt:Q9H944 MED20	1	MED20 [nucleoplasm] (R-HSA-212428)	0.527	3
UniProt:P24863 CCNC	1	CCNC [nucleoplasm] (R-HSA-212418)	0.527	3
UniProt:Q6P2C8 MED27	1	MED27 [nucleoplasm] (R-HSA-556761)	0.527	2
UniProt:Q12888 TP53BP1	3	TP53BP1 [nucleoplasm] (R-HSA-61175) p-S25,S1778-TP53BP1 [nucleoplasm] (R-HSA-5683418) monoSUMO1-K-TP53BP1 [nucleoplasm] (R-HSA-2997591)	0.483	2
UniProt:Q9ULK4 MED23	1	MED23 [nucleoplasm] (R-HSA-556823)	0.483	2