Reactome | MED18 [nucleoplasm]

MED18 [nucleoplasm]

Stable Identifier

R-HSA-556826

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Mediator of RNA polymerase II transcription subunit 18, MED18_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Respiratory Syncytial Virus Infection Pathway (Homo sapiens)
      - RSV-host interactions (Homo sapiens)
        
        NS1 (1C) binds to Mediator complex (Homo sapiens)
        
        Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
        
        MED18 [nucleoplasm] (Homo sapiens)
        
        Mediator:NS1 [nucleoplasm] (Homo sapiens)
        
        Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
        
        MED18 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9BUE0 MED18

Gene Names

MED18

Chain

chain:1-208

Reference Genes

BioGPS Gene:54797 MED18

COSMIC (genes):MED18 MED18

CTD Gene:54797 MED18

dbSNP Gene:54797 MED18

ENSEMBL:ENSG00000130772 MED18

HGNC:25944 MED18

KEGG:hsa:54797 MED18

Monarch:54797 MED18

NCBI Gene:54797 MED18

OMIM:612384 MED18

UCSC:Q9BUE0 MED18

Reference Transcript

Other Identifiers

11732253_x_at

11732254_a_at

16661556

219730_PM_at

219730_at

221650_PM_s_at

221650_s_at

2327419

2327420

2327421

2327422

2327423

2327424

2327425

2327426

2327427

2327428

2327429

47122_at

54797

7899448

A_14_P200893

A_23_P138105

A_33_P3347639

GE55343

GO:0000151

GO:0003712

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0006355

GO:0006357

GO:0006369

GO:0016567

GO:0016592

GO:0016740

GO:0032968

GO:0043226

GO:0051123

GO:0060090

GO:0060261

GO:0061630

GO:0065003

GO:0070847

GO:0140096

GO:0140110

HMNXSV003025873

HMNXSV003042604

ILMN_1788528

PH_hs_0026467

TC01000378.hg

g12803716_3p_a_at

Participates

as a component of

Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)

Cross References

OpenTargets

ENSG00000130772

ENSEMBL

ENSP00000494048, ENST00000647352, ENST00000645794, ENSG00000130772, ENSP00000381963, ENST00000373842, ENSP00000494184, ENSP00000362948, ENSG00000284944, ENST00000398997

HPA

ENSG00000130772-MED18

GeneCards

MED18

PRO

Q9BUE0

Pharos - Targets

Q9BUE0

GlyGen

Q9BUE0

PDB

7LBM, 8GXS, 7NVR, 7ENJ, 8GXQ, 7ENC, 7ENA, 8TQW, 8TRH, 7EMF, 8T9D

Interactors (24)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9H944 MED20	1	MED20 [nucleoplasm] (R-HSA-212428)	0.959	26
UniProt:Q9BTT4 MED10	1	MED10 [nucleoplasm] (R-HSA-212410)	0.92	14
UniProt:Q9NPJ6 MED4	1	MED4 [nucleoplasm] (R-HSA-350263)	0.802	9
UniProt:P49336 CDK8	1	CDK8 [nucleoplasm] (R-HSA-212440)	0.802	10
UniProt:Q9NVC6 MED17	1	MED17 [nucleoplasm] (R-HSA-212401)	0.802	7
UniProt:O95402 MED26	1	MED26 [nucleoplasm] (R-HSA-556783)	0.788	9
UniProt:O75586 MED6	1	MED6 [nucleoplasm] (R-HSA-212359)	0.744	6
UniProt:Q15648 MED1	1	MED1 [nucleoplasm] (R-HSA-212445)	0.725	6
UniProt:Q9Y3C7 MED31	1	MED31 [nucleoplasm] (R-HSA-212429)	0.725	7
UniProt:O60244 MED14	1	MED14 [nucleoplasm] (R-HSA-212441)	0.725	6
UniProt:Q96HR3 MED30	1	MED30 [nucleoplasm] (R-HSA-212398)	0.725	6
UniProt:Q93074 MED12	1	MED12 [nucleoplasm] (R-HSA-212343)	0.725	6
UniProt:O43513 MED7	1	MED7 [nucleoplasm] (R-HSA-212430)	0.725	6
UniProt:Q96G25 MED8	1	MED8 [nucleoplasm] (R-HSA-556784)	0.643	6
UniProt:Q9UHV7 MED13	1	MED13 [nucleoplasm] (R-HSA-212391)	0.643	5
UniProt:Q6P2C8 MED27	1	MED27 [nucleoplasm] (R-HSA-556761)	0.643	6
UniProt:O75448 MED24	1	MED24 [nucleoplasm] (R-HSA-212331)	0.643	5
UniProt:Q9ULK4 MED23	1	MED23 [nucleoplasm] (R-HSA-556823)	0.615	5
UniProt:Q63HM1 AFMID	1	AFMID [cytosol] (R-HSA-178107)	0.556	3
UniProt:P19388 POLR2E	2	POLR2E [cytosol] (R-HSA-1964438) POLR2E [nucleoplasm] (R-HSA-83713)	0.527	2
UniProt:P24863 CCNC	1	CCNC [nucleoplasm] (R-HSA-212418)	0.527	4
UniProt:Q9Y2X0 MED16	1	MED16 [nucleoplasm] (R-HSA-556802)	0.527	4
UniProt:O15392 BIRC5	3	BIRC5 [cytosol] (R-HSA-50851) BIRC5 [nucleoplasm] (R-HSA-4655344) ub-BIRC5 [cytosol] (R-HSA-8955933)	0.527	2
UniProt:Q9NYA4 MTMR4	2	MTMR4 [cytosol] (R-HSA-1604658) MTMR4 [early endosome membrane] (R-HSA-2187404)	0.527	2