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MED18 [nucleoplasm]
Stable Identifier
R-HSA-556826
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Mediator of RNA polymerase II transcription subunit 18, MED18_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Adipogenesis (Homo sapiens)
Transcriptional regulation of white adipocyte differentiation (Homo sapiens)
Expression of ANGPTL4 (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED18 [nucleoplasm] (Homo sapiens)
Expression of Adiponectin (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED18 [nucleoplasm] (Homo sapiens)
Expression of CD36 (platelet glycoprotein IV, FAT) (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED18 [nucleoplasm] (Homo sapiens)
Expression of CEBPA (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED18 [nucleoplasm] (Homo sapiens)
Expression of FABP4 (aP2) (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED18 [nucleoplasm] (Homo sapiens)
Expression of Leptin (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED18 [nucleoplasm] (Homo sapiens)
Expression of Lipoprotein lipase (LPL) (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED18 [nucleoplasm] (Homo sapiens)
Expression of Perilipin (PLIN) (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED18 [nucleoplasm] (Homo sapiens)
Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C) (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED18 [nucleoplasm] (Homo sapiens)
PPARG:RXRA heterodimer binds to fatty acid-like ligands (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED18 [nucleoplasm] (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED18 [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
Respiratory Syncytial Virus Infection Pathway (Homo sapiens)
RSV-host interactions (Homo sapiens)
NS1 (1C) binds to Mediator complex (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED18 [nucleoplasm] (Homo sapiens)
Mediator:NS1 [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED18 [nucleoplasm] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Regulation of lipid metabolism by PPARalpha (Homo sapiens)
PPARA activates gene expression (Homo sapiens)
Expression of ANGPTL4 (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED18 [nucleoplasm] (Homo sapiens)
Expression of CD36 (platelet glycoprotein IV, FAT) (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED18 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9BUE0 MED18
Gene Names
MED18
Chain
chain:1-208
Reference Genes
BioGPS Gene:54797 MED18
COSMIC (genes):MED18 MED18
CTD Gene:54797 MED18
dbSNP Gene:54797 MED18
ENSEMBL:ENSG00000130772 MED18
HGNC:25944 MED18
KEGG:hsa:54797 MED18
Monarch:54797 MED18
NCBI Gene:54797 MED18
OMIM:612384 MED18
UCSC:Q9BUE0 MED18
Reference Transcript
RefSeq:XM_005245914.4 MED18
RefSeq:NM_017638.2 MED18
RefSeq:NM_001127350.1 MED18
Other Identifiers
11732253_x_at
11732254_a_at
16661556
219730_PM_at
219730_at
221650_PM_s_at
221650_s_at
2327419
2327420
2327421
2327422
2327423
2327424
2327425
2327426
2327427
2327428
2327429
47122_at
54797
7899448
A_14_P200893
A_23_P138105
A_33_P3347639
GE55343
GO:0000151
GO:0003712
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0006355
GO:0006357
GO:0006369
GO:0016567
GO:0016592
GO:0016740
GO:0032968
GO:0043226
GO:0051123
GO:0060090
GO:0060261
GO:0061630
GO:0065003
GO:0070847
GO:0140096
GO:0140110
HMNXSV003025873
HMNXSV003042604
ILMN_1788528
PH_hs_0026467
TC01000378.hg
g12803716_3p_a_at
Participates
as a component of
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
Cross References
OpenTargets
ENSG00000130772
ENSEMBL
ENSP00000494048
,
ENST00000647352
,
ENST00000645794
,
ENSG00000130772
,
ENSP00000381963
,
ENST00000373842
,
ENSP00000494184
,
ENSP00000362948
,
ENSG00000284944
,
ENST00000398997
HPA
ENSG00000130772-MED18
GeneCards
MED18
PRO
Q9BUE0
Pharos - Targets
Q9BUE0
GlyGen
Q9BUE0
PDB
7LBM
,
8GXS
,
7NVR
,
7ENJ
,
8GXQ
,
7ENC
,
7ENA
,
8TQW
,
8TRH
,
7EMF
,
8T9D
Interactors (24)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9H944 MED20
1
MED20 [nucleoplasm]
(R-HSA-212428)
0.959
26
UniProt:Q9BTT4 MED10
1
MED10 [nucleoplasm]
(R-HSA-212410)
0.92
14
UniProt:Q9NPJ6 MED4
1
MED4 [nucleoplasm]
(R-HSA-350263)
0.802
9
UniProt:P49336 CDK8
1
CDK8 [nucleoplasm]
(R-HSA-212440)
0.802
10
UniProt:Q9NVC6 MED17
1
MED17 [nucleoplasm]
(R-HSA-212401)
0.802
7
UniProt:O95402 MED26
1
MED26 [nucleoplasm]
(R-HSA-556783)
0.788
9
UniProt:O75586 MED6
1
MED6 [nucleoplasm]
(R-HSA-212359)
0.744
6
UniProt:Q15648 MED1
1
MED1 [nucleoplasm]
(R-HSA-212445)
0.725
6
UniProt:Q9Y3C7 MED31
1
MED31 [nucleoplasm]
(R-HSA-212429)
0.725
7
UniProt:O60244 MED14
1
MED14 [nucleoplasm]
(R-HSA-212441)
0.725
6
UniProt:Q96HR3 MED30
1
MED30 [nucleoplasm]
(R-HSA-212398)
0.725
6
UniProt:Q93074 MED12
1
MED12 [nucleoplasm]
(R-HSA-212343)
0.725
6
UniProt:O43513 MED7
1
MED7 [nucleoplasm]
(R-HSA-212430)
0.725
6
UniProt:Q96G25 MED8
1
MED8 [nucleoplasm]
(R-HSA-556784)
0.643
6
UniProt:Q9UHV7 MED13
1
MED13 [nucleoplasm]
(R-HSA-212391)
0.643
5
UniProt:Q6P2C8 MED27
1
MED27 [nucleoplasm]
(R-HSA-556761)
0.643
6
UniProt:O75448 MED24
1
MED24 [nucleoplasm]
(R-HSA-212331)
0.643
5
UniProt:Q9ULK4 MED23
1
MED23 [nucleoplasm]
(R-HSA-556823)
0.615
5
UniProt:Q63HM1 AFMID
1
AFMID [cytosol]
(R-HSA-178107)
0.556
3
UniProt:P19388 POLR2E
2
POLR2E [cytosol]
(R-HSA-1964438)
POLR2E [nucleoplasm]
(R-HSA-83713)
0.527
2
UniProt:P24863 CCNC
1
CCNC [nucleoplasm]
(R-HSA-212418)
0.527
4
UniProt:Q9Y2X0 MED16
1
MED16 [nucleoplasm]
(R-HSA-556802)
0.527
4
UniProt:O15392 BIRC5
3
BIRC5 [cytosol]
(R-HSA-50851)
BIRC5 [nucleoplasm]
(R-HSA-4655344)
ub-BIRC5 [cytosol]
(R-HSA-8955933)
0.527
2
UniProt:Q9NYA4 MTMR4
2
MTMR4 [cytosol]
(R-HSA-1604658)
MTMR4 [early endosome membrane]
(R-HSA-2187404)
0.527
2
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