Reactome | MED18 [nucleoplasm]

MED18 [nucleoplasm]

Stable Identifier

R-HSA-556826

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Mediator of RNA polymerase II transcription subunit 18, MED18_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9BUE0 MED18

Gene Names

MED18

Chain

chain:1-208

Reference Genes

BioGPS Gene:54797 MED18

COSMIC (genes):MED18 MED18

CTD Gene:54797 MED18

dbSNP Gene:54797 MED18

ENSEMBL:ENSG00000130772 MED18

ENSEMBL:ENSG00000130772.14 MED18

ENSEMBL:ENSG00000284944.2 MED18

HGNC:25944 MED18

KEGG Gene (Homo sapiens):54797 MED18

Monarch:54797 MED18

NCBI Gene:54797 MED18

OMIM:612384 MED18

UCSC:Q9BUE0 MED18

Reference Transcript

Other Identifiers

0005390717

11732253_x_at

11732254_a_at

16661556

219730_PM_at

219730_at

221650_PM_s_at

221650_s_at

2327419

2327420

2327421

2327423

2327424

2327426

2327427

2327428

2327429

47122_at

54797

7899448

A_14_P200893

A_23_P138105

A_33_P3347639

GE55343

GO:0003712

GO:0005515

GO:0005622

GO:0005634

GO:0006351

GO:0006354

GO:0006355

GO:0006357

GO:0006369

GO:0016592

GO:0032968

GO:0032991

GO:0043226

GO:0051123

GO:0060261

GO:0065003

GO:0070847

HMNXSV003025873

HMNXSV003042604

ILMN_1788528

PH_hs_0026467

TC01000378.hg

g12803716_3p_a_at

Participates

as a component of

Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_060108.2, XP_005245971.1, NP_001120822.1

OpenTargets

ENSG00000130772

GeneCards

Q9BUE0

HPA

ENSG00000130772-MED18

Ensembl

ENSP00000494184, ENSP00000381963, ENST00000398997, ENSP00000362948, ENST00000373842, ENST00000645794, ENSG00000284944, ENSP00000494048, ENSG00000130772, ENST00000647352

PRO

Q9BUE0

Pharos - Targets

Q9BUE0

PDB

7EMF, 7LBM, 7NVR, 7ENC, 7ENJ, 7ENA

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9H944 MED20	1	MED20 [nucleoplasm] (R-HSA-212428)	0.932	21
UniProt:Q9BTT4 MED10	1	MED10 [nucleoplasm] (R-HSA-212410)	0.901	9
UniProt:P49336 CDK8	1	CDK8 [nucleoplasm] (R-HSA-212440)	0.745	7
UniProt:O95402 MED26	1	MED26 [nucleoplasm] (R-HSA-556783)	0.725	6
UniProt:Q9NPJ6 MED4	1	MED4 [nucleoplasm] (R-HSA-350263)	0.671	4
UniProt:Q9NVC6 MED17	1	MED17 [nucleoplasm] (R-HSA-212401)	0.669	3
UniProt:O75586 MED6	1	MED6 [nucleoplasm] (R-HSA-212359)	0.669	3
UniProt:Q63HM1 AFMID	1	AFMID [cytosol] (R-HSA-178107)	0.556	3
UniProt:Q9Y3C7 MED31	1	MED31 [nucleoplasm] (R-HSA-212429)	0.527	2
UniProt:Q15648 MED1	1	MED1 [nucleoplasm] (R-HSA-212445)	0.527	2
UniProt:O60244 MED14	1	MED14 [nucleoplasm] (R-HSA-212441)	0.527	2
UniProt:Q93074 MED12	1	MED12 [nucleoplasm] (R-HSA-212343)	0.527	2
UniProt:O43513 MED7	1	MED7 [nucleoplasm] (R-HSA-212430)	0.527	2
UniProt:Q9UHV7 MED13	1	MED13 [nucleoplasm] (R-HSA-212391)	0.527	2
UniProt:Q96HR3 MED30	1	MED30 [nucleoplasm] (R-HSA-212398)	0.527	2