Reactome | KCNH2:KCNE transport K+ from cytosol to extracellular region

KCNH2:KCNE transport K+ from cytosol to extracellular region

Stable Identifier

R-HSA-5577237

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

ReviewStatus

5/5

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KCNH2:KCNE transport K+ from cytosol to extracellular region

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Two potassium currents, I_Ks and I_Kr, provide the principal repolarising currents in cardiac myocytes for the termination of action potentials. The potassium voltage-gated channel subfamily H member 2 (KCNH2 aka HERG) is the pore-forming alpha subunit of a stable complex with a regulating beta subunit of the potassium voltage-gated channel subfamily E family (KCNE). This stable complex creates the _Kr current by the efflux of K+ (Macdonald et al. 1997, Abbott et al. 1999).

Literature References

PubMed ID	Title	Journal	Year
9230439	A minK-HERG complex regulates the cardiac potassium current I(Kr) Palma, E, Fishman, GI, Ming, Z, Goldstein, SA, Yu, Z, Meyers, MB, McDonald, TV, Wang, KW	Nature	1997
10219239	MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia Abbott, GW, Keating, MT, Timothy, KW, Buck, ME, Sesti, F, Goldstein, SA, Lehmann, MH, Splawski, I	Cell	1999