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EIF2C1 [nucleoplasm]
Stable Identifier
R-HSA-5578686
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Argonaute-1, AGO1
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
Gene Silencing by RNA (Homo sapiens)
Transcriptional regulation by small RNAs (Homo sapiens)
AGO1,2:small RNA complexes interact with chromatin (Homo sapiens)
AGO1,2:miRNA [nucleoplasm] (Homo sapiens)
AGO1:miRNA [nucleoplasm] (Homo sapiens)
EIF2C1 [nucleoplasm] (Homo sapiens)
AGO1,2:miRNA:chromatin:RNA pol II [nucleoplasm] (Homo sapiens)
AGO1,2:miRNA [nucleoplasm] (Homo sapiens)
AGO1:miRNA [nucleoplasm] (Homo sapiens)
EIF2C1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UL18 AGO1
Gene Names
AGO1, EIF2C1
Chain
chain:1-857
Reference Genes
BioGPS Gene:26523 AGO1
COSMIC (genes):AGO1 AGO1
CTD Gene:26523 AGO1
dbSNP Gene:26523 AGO1
ENSEMBL:ENSG00000092847 AGO1
HGNC:3262 AGO1
KEGG:hsa:26523 AGO1
Monarch:26523 AGO1
NCBI Gene:26523 AGO1
OMIM:606228 AGO1
UCSC:Q9UL18 AGO1
Reference Transcript
RefSeq:NM_001317123.1 AGO1
RefSeq:NM_001317122.1 AGO1
RefSeq:NM_012199.4 AGO1
Other Identifiers
11720866_a_at
11755432_a_at
16662453
218287_PM_s_at
218287_s_at
222576_PM_s_at
222576_s_at
228120_PM_at
228120_at
2330076
2330078
2330079
2330080
2330086
2330088
2330090
2330091
2330092
2330093
2330094
2330096
2330097
2330098
2330099
2330101
2330104
2330108
2330110
2330111
2330112
2330113
2330115
2330116
2330117
2330118
2330119
2330120
2330121
2330122
2330123
2330124
2330125
2330126
2330127
2330128
2330129
2330130
2330131
2330132
2330134
2330135
2330136
2330137
2330138
2330139
239036_PM_at
239036_at
26523
43036_at
47463_at
53837_at
73531_at
7900030
87639_at
88862_at
A_23_P11764
A_24_P96749
A_33_P3380587
A_33_P3402116
GE56968
GE81768
GO:0000932
GO:0000956
GO:0000993
GO:0001046
GO:0003676
GO:0003677
GO:0003723
GO:0003725
GO:0003727
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006355
GO:0006417
GO:0010501
GO:0016071
GO:0016442
GO:0016525
GO:0031047
GO:0031054
GO:0035194
GO:0035196
GO:0035198
GO:0035278
GO:0036464
GO:0043226
GO:0043232
GO:0043488
GO:0045944
GO:0061980
GO:0065003
GO:0070578
GO:0070922
GO:1990904
HMNXSV003019955
Hs.14520.0.S1_3p_a_at
Hs.22867.0.S1_3p_at
Hs.230151.0.A1_3p_at
ILMN_1671326
PH_hs_0023696
TC01000463.hg
TC01000464.hg
TC01004315.hg
g6912351_3p_a_at
p25685
Participates
as a component of
AGO1:miRNA [nucleoplasm] (Homo sapiens)
Other forms of this molecule
EIF2C1 [cytosol]
Inferred To
tag-76 [nucleoplasm]
(Caenorhabditis elegans)
wago-4 [nucleoplasm]
(Caenorhabditis elegans)
AGO1 [nucleoplasm]
(Bos taurus)
AGO1 [nucleoplasm]
(Canis familiaris)
AGO1 [nucleoplasm]
(Drosophila melanogaster)
AGO1 [nucleoplasm]
(Gallus gallus)
wago-5 [nucleoplasm]
(Caenorhabditis elegans)
ergo-1 [nucleoplasm]
(Caenorhabditis elegans)
ppw-2 [nucleoplasm]
(Caenorhabditis elegans)
ago1 [nucleoplasm]
(Schizosaccharomyces pombe)
ago1 [nucleoplasm]
(Xenopus tropicalis)
Homologues of EIF2C1 [nucleoplasm]
(Caenorhabditis elegans)
Homologues of EIF2C1 [nucleoplasm]
(Drosophila melanogaster)
Ago1 [nucleoplasm]
(Rattus norvegicus)
vsra-1 [nucleoplasm]
(Caenorhabditis elegans)
alg-5 [nucleoplasm]
(Caenorhabditis elegans)
alg-2 [nucleoplasm]
(Caenorhabditis elegans)
csr-1 [nucleoplasm]
(Caenorhabditis elegans)
rde-1 [nucleoplasm]
(Caenorhabditis elegans)
wago-1 [nucleoplasm]
(Caenorhabditis elegans)
alg-3 [nucleoplasm]
(Caenorhabditis elegans)
alg-1 [nucleoplasm]
(Caenorhabditis elegans)
EIF2C1 [nucleoplasm]
(Drosophila melanogaster)
Cross References
RefSeq
NP_036331.1
,
NP_001304051.1
,
NP_001304052.1
ENSEMBL
ENSP00000362300
,
ENST00000373204
,
ENSG00000092847
OpenTargets
ENSG00000092847
GeneCards
AGO1
HPA
ENSG00000092847-AGO1
PRO
Q9UL18
Pharos - Targets
Q9UL18
GlyGen
Q9UL18
Orphanet
AGO1
PDB
1SI2
,
5W6V
,
4KXT
,
4KRE
,
1SI3
,
4KRF
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8NDV7 TNRC6A
2
TNRC6A [nucleoplasm]
(R-HSA-5578976)
TNRC6A [cytosol]
(R-HSA-427769)
0.867
8
UniProt:Q9UPY3 DICER1
1
DICER1 [cytosol]
(R-HSA-203820)
0.784
8
UniProt:Q9UKV8 AGO2
2
AGO2 [cytosol]
(R-HSA-209723)
AGO2 [nucleoplasm]
(R-HSA-5578701)
0.723
7
UniProt:P08238 HSP90AB1
6
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
0.669
5
UniProt:Q15633 TARBP2
2
p-TARBP2 [cytosol]
(R-HSA-9835348)
TARBP2 [cytosol]
(R-HSA-203864)
0.643
5
UniProt:Q13451 FKBP5
2
FKBP5 [nucleoplasm]
(R-HSA-8939165)
FKBP5 [cytosol]
(R-HSA-5618096)
0.643
4
UniProt:P04156 PRNP
2
PRNP [plasma membrane]
(R-HSA-375060)
PRNP [cytosol]
(R-HSA-9617597)
0.609
2
UniProt:P11940 PABPC1
1
PABPC1 [cytosol]
(R-HSA-156803)
0.527
4
UniProt:P67809 YBX1
5
p-S32,S36-YBX1 [nucleoplasm]
(R-HSA-9733227)
p-S32,S36-YBX1 [cytosol]
(R-HSA-9736837)
YBX1 [cytosol]
(R-HSA-9736840)
YBX1 [nucleoplasm]
(R-HSA-72041)
YBX1 [extracellular region]
(R-HSA-9017791)
0.527
4
UniProt:O15397 IPO8
2
IPO8 [cytosol]
(R-HSA-5578740)
IPO8 [nucleoplasm]
(R-HSA-5578747)
0.524
2
UniProt:P53041 PPP5C
2
PPP5C [nucleoplasm]
(R-HSA-5683410)
PPP5C [cytosol]
(R-HSA-5675402)
0.499
2
UniProt:Q12906 ILF3
3
ILF3 [nucleoplasm]
(R-HSA-9760401)
ILF3 [cytosol]
(R-HSA-450564)
p-T188,T315-ILF3 [cytosol]
(R-HSA-9836381)
0.483
3
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